BACKGROUND & AIMS:
OBJECTIVE:The study aimed to assess the use of Integrated Mismatch Negativity (MMNi) in differentiating children with specific language impairment (SLI) from a control group.
DESIGN:Six conditions were created using a 1,000-Hz standard stimulus with three deviants of 1,020, 1,050, or 1,100 Hz and two interstimulus intervals of 400 and 200 ms. Recordings were processed offline using NeuroScan Edit (NeuroScan, Texas, United States). Four time analysis points were chosen and the magnitude of the integrated deviant was compared with the 100 standard subaverages. Mismatch negativity (MMN) presence was determined when 10 or less of the standard subaverages were less than the deviant subaverage magnitude.
STUDY PARTICIPANTS:A total of 18 children with SLI and 35 typical development children participated in the study.
RESULTS:Pearson chi-square test demonstrated that the proportion of MMN presence in the SLI group was not significantly different from the control group and it did not vary with condition. Two-way between-group analysis of variance confirmed that using 1,000 Hz standard, 1,050 Hz deviant, and 400 ms interstimulus interval was significantly different from the other conditions.
CONCLUSION:MMNi does not serve as a tool for identifying children with SLI when using pure-tone stimuli. However, using different time analysis points with MMNi should be explored further, particularly with speech material.
背景与目标:
目的:本研究旨在评估综合失配阴性(MMNi)在区分具有特定语言障碍(SLI)的儿童与对照组中的作用。
设计:使用1,000Hz标准刺激物创建六个条件,其中三个偏差分别为1,020、1,050或1,100 Hz,两个刺激间隔为400和200 ms。使用NeuroScan Edit(美国得克萨斯州,NeuroScan)对记录进行脱机处理。选择了四个时间分析点,并将积分偏差的大小与100个标准子平均值进行了比较。当10个或更少的标准子平均值小于偏差子平均值幅度时,确定不匹配负性(MMN)的存在。
研究对象:共有18名SLI儿童和35名典型发育儿童参加了研究。
结果:Pearson卡方检验表明,SLI组中MMN的存在比例与对照组无显着差异,并且随状况而变化。两组之间的方差分析证实,使用1,000 Hz标准,1,050 Hz偏差和400 ms激励间隔与其他条件有显着差异。
结论:使用纯音刺激时,MMNi不能作为识别SLI儿童的工具。但是,应进一步探索对MMNi使用不同的时间分析点,尤其是语音材料。