BACKGROUND & AIMS:
OBJECTIVES:To assess the influence of race on long-term outcomes following percutaneous coronary intervention (PCI) with paclitaxel-eluting stents (PES).
BACKGROUND:Data on the influence of race on long-term outcomes following PCI with drug-eluting stents are limited because of severe underrepresentation of minority populations in randomized trials.
METHODS:We compared 5-year outcomes of 2,301 whites, 127 blacks, and 169 Asians treated with PES in the TAXUS IV, V, and ATLAS trials. Outcomes were adjusted using a propensity score logistic regression model with 1:4 matching.
RESULTS:Blacks were more likely than whites to be female, have a history of hypertension, diabetes mellitus, congestive heart failure, and stroke, but were less likely to have prior coronary artery disease. Compared with whites, Asians were younger, more likely to be male, have stable angina, and left anterior descending disease, and less likely to have silent ischemia, previous coronary artery bypass surgery, prior coronary artery disease, diabetes mellitus, peripheral vascular disease, and to receive glycoprotein IIb/IIIa inhibitors. Despite higher antiplatelet compliance, the adjusted 5-year rates of myocardial infarction (15.4% vs. 5.4%, P < 0.001) and stent thrombosis (5.6% vs. 1.1%, P = 0.002) were higher in blacks than whites. Despite lower antiplatelet compliance, Asians had no differences in myocardial infarction and stent thrombosis compared with whites. Mortality and revascularization rates were similar between the three groups.
CONCLUSIONS:The long-term risk of major thrombotic events after PCI with PES was higher in blacks, but not Asians, compared with whites. The mechanisms underlying these racial differences warrant further investigation.
背景与目标:
目的:评估种族对紫杉醇洗脱支架(PES)经皮冠状动脉介入治疗(PCI)后长期结局的影响。
背景:由于随机试验中少数群体的严重代表性不足,有关种族对药物洗脱支架PCI后长期预后影响的数据有限。
方法:在TAXUS IV,V和ATLAS试验中,我们比较了接受PES治疗的2,301名白人,127名黑人和169名亚洲人的5年结局。结果使用倾向评分逻辑回归模型与1:4匹配进行调整。
结果:黑人比白人更有可能是女性,有高血压,糖尿病,充血性心力衰竭和中风的病史,但以前患有冠状动脉疾病的可能性较小。与白人相比,亚洲人更年轻,男性更容易,有稳定的心绞痛和左前降支疾病,无声缺血,先前进行冠状动脉搭桥手术,先前有冠状动脉疾病,糖尿病,周围血管疾病,并接受糖蛋白IIb / IIIa抑制剂。尽管抗血小板依从性更高,但黑人的白人校正后5年心肌梗塞发生率(15.4%vs. 5.4%,P <0.001)和支架内血栓形成(5.6%vs. 1.1%,P = 0.002)高于白人。尽管抗血小板依从性较低,但与白人相比,亚洲人在心肌梗塞和支架血栓形成方面无差异。两组的死亡率和血运重建率相似。
结论:与白人相比,黑人(而非亚洲人)的PCI与PES术后PCI发生重大血栓事件的长期风险更高。这些种族差异的潜在机制值得进一步调查。