BACKGROUND:Among the most serious sequelae to an initial episode of Major Depressive Disorder (MDD) during adolescence is the significant increase in the probability of recurrence. This study reports on an integrated CBT/IPT program, provided in a group format, that was developed to decrease the rate of MDD recurrence in emerging adults. METHODS:Participants were 89 young adults who were not depressed at study entry but had experienced MDD during adolescence. Participants were assigned to a CBT/IPT prevention program or to an assessment only control condition and were followed through the first 2 years of college. RESULTS:Risk for MDD recurrence was reduced more than 50% for the prevention program participants compared to assessment only controls. The intervention also conferred beneficial effects on academic performance for those students who completed the majority of the group sessions. LIMITATIONS:The study included a self-selected sample of emerging adults who were aware of their history of depression. Due to the small sample size, it will be important to evaluate similar interventions in adequately-powered trials to determine if this is a replicable finding. CONCLUSIONS:With 51% of the assessment only participants experiencing a MDD recurrence during the first 2 years of college, these findings support the need for programs designed to prevent MDD recurrence in young adults. The current program, based on IPT and CBT principles, appears to reduce the rate of MDD recurrence among previously depressed emerging adults.

译文

背景:在青春期主要抑郁症(MDD)初期发作的最严重后遗症中,复发几率显着增加。这项研究报告了以小组形式提供的综合CBT / IPT计划,该计划旨在降低新兴成年人的MDD复发率。
方法:参与者为89位年轻成年人,他们在入学时并未感到沮丧,但在青春期曾经历过MDD。参与者被分配到CBT / IPT预防计划或仅评估控制状况,并被跟踪到大学学习的前两年。
结果:与仅评估对照组相比,预防计划参与者的MDD复发风险降低了50%以上。干预还为完成大部分小组课程的学生们的学业成绩带来了有益的影响。
局限性:该研究包括自我选择的新兴成年人的样本,这些成年人意识到他们的抑郁症史。由于样本量较小,因此在足够有力的试验中评估类似干预措施,以确定这是否是可重复的发现,这一点很重要。
结论:只有51%的评估参与者在大学的头两年内经历了MDD复发,这些发现支持需要制定旨在预防年轻人MDD复发的计划。基于IPT和CBT原则的当前计划似乎降低了先前抑郁的新兴成年人中MDD复发率。

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