BACKGROUND & AIMS:
OBJECTIVES:To describe the 15-year incidence of retinal vein occlusion (central retinal vein occlusion and branch retinal vein occlusion) and associated risk factors.
METHODS:A population-based study where branch retinal vein occlusion and central retinal vein occlusion were detected at baseline (n = 4068, 1988-1990) and three 5-year follow-up examinations by grading 30 degrees color fundus photographs.
RESULTS:The 15-year cumulative incidences of branch retinal vein occlusion and central retinal vein occlusion were 1.8% and 0.5%, respectively. Using a generalized estimating equation model, incident retinal vein occlusion was related to baseline age (odds ratio [OR] per 10 years, 1.70; 95% confidence interval [CI], 1.36-2.12), history of barbiturate use (OR, 5.30; 95% CI, 2.28-12.31), focal retinal arteriolar narrowing (OR, 2.45; 95% CI, 1.29-4.66), glaucoma (OR, 3.17; 95% CI, 1.50-6.69), serum ionized calcium level (OR per 0.4 mg/dL, 0.43; 95% CI, 0.23-0.79), serum phosphorus level (OR per 0.3 mg/dL, 1.15; 95% CI, 1.01-1.30), and serum creatinine level (OR for > or = 1.4 vs < 1.4 mg/dL, 1.61; 95% CI, 1.00-2.59). Migraine headache history was associated with branch retinal vein occlusion (OR, 1.99; 95% CI, 1.08-3.67). Diabetes history was associated with central retinal vein occlusion (OR, 6.35; 95% CI, 1.90-21.27).
CONCLUSIONS:Incident retinal vein occlusion is not infrequent in the population, especially after age 65 years. The relationships of barbiturate use, serum creatinine level, serum ionized calcium level, and serum phosphorus level with incident retinal vein occlusion require further assessment in other large population-based studies.
背景与目标:
目的:描述视网膜静脉阻塞(中央视网膜静脉阻塞和视网膜分支静脉阻塞)的15年发生率及相关危险因素。
方法:一项基于人群的研究,在基线时(n = 4068,1988-1990)检测视网膜分支静脉阻塞和视网膜中央静脉阻塞,并通过对30度彩色眼底照片进行分级,进行了3次为期5年的随访检查。
结果:视网膜分支静脉阻塞和视网膜中央静脉阻塞的15年累积发生率分别为1.8%和0.5%。使用广义估计方程模型,入射视网膜静脉阻塞与基线年龄(每10年的比值比[OR],1.70; 95%的置信区间[CI],1.36-2.12),巴比妥类药物的使用史(OR,5.30; 1.0)有关。 95%CI,2.28-12.31),局灶性视网膜小动脉狭窄(OR,2.45; 95%CI,1.29-4.66),青光眼(OR,3.17; 95%CI,1.50-6.69),血清离子钙水平(OR / 0.4 mg / dL,0.43; 95%CI,0.23-0.79),血清磷水平(OR / 0.3 mg / dL,1.15; 95%CI,1.01-1.30),血清肌酐水平(>或= 1.4 vs < 1.4 mg / dL,1.61; 95%CI,1.00-2.59)。偏头痛的病史与视网膜分支静脉阻塞有关(OR,1.99; 95%CI,1.08-3.67)。糖尿病史与视网膜中央静脉阻塞有关(OR,6.35; 95%CI,1.90-21.27)。
结论:人群中视网膜静脉阻塞的发生并不罕见,尤其是在65岁以后。巴比妥酸盐的使用,血清肌酐水平,血清离子钙水平和血清磷水平与视网膜静脉静脉阻塞的关系还需要在其他基于人群的大型研究中进一步评估。