BACKGROUND & AIMS:
:Sexual dysfunction is common with selective serotonin reuptake inhibitor use for major depressive disorder. Studies have shown associations between genetic variation in the adenosine triphosphate (ATP)-binding cassette, subfamily B, member 1 gene (ABCB1), which encodes the drug efflux transporter P-glycoprotein (PGP), and selective serotonin reuptake inhibitor response. This study measured functionally implicated ABCB1 variants (rs2235015, rs1128503, rs2032582, and rs1045642) and sexual dysfunction using the Changes in Sexual Functioning Questionnaire. This study included outpatients (18-40 years of age) treated for major depressive disorder with a selective serotonin reuptake inhibitor for 6 weeks. Changes in Sexual Functioning Questionnaire outcomes were stratified by ABCB1 genotype and PGP substrate status. The authors recruited 82 individuals (22 men and 57 women). Women receiving a PGP substrate with a rs1128503 TT genotype had a significantly lower Changes in Sexual Functioning Questionnaire total score (37.2 ± 5.4), indicating greater sexual dysfunction, than did those with the CT (42.9 ± 6.3) or CC genotypes (46.6 ± 5.6), F(2) = 6.00, p = .005, p = .02, with multiple testing correction. The results indicate a relationship between genotypes at rs1128503, total sexual dysfunction, and PGP substrates use for women and may explain some of the sexual dysfunction variability seen with selective serotonin reuptake inhibitor treatment. Results need to be confirmed with a larger sample size that includes men.
背景与目标:
: 性功能障碍与选择性5-羟色胺再摄取抑制剂治疗重度抑郁症很常见。研究表明,三磷酸腺苷 (ATP) 结合盒,亚家族B,成员1基因 (ABCB1) (编码药物外排转运蛋白P-糖蛋白 (PGP)) 的遗传变异与选择性5-羟色胺再摄取抑制剂反应之间存在关联。这项研究使用性功能问卷的变化来测量与功能有关的ABCB1变体 (rs2235015,rs1128503,rs2032582和rs1045642) 和性功能障碍。这项研究包括门诊患者 (18-40岁) 接受选择性5-羟色胺再摄取抑制剂治疗6周的重度抑郁症。通过ABCB1基因型和PGP底物状态对性功能问卷结果的变化进行分层。作者招募了82人 (22名男性和57名女性)。与具有CT (42.9 ± 6.3) 或CC基因型 (46.6 ± 5.6) 的女性相比,接受rs1128503 TT基因型的PGP底物的女性在性功能问卷总分 (37.2 ± 5.4) 明显降低,表明性功能障碍更大,F(2) = 6.00,p = .005,p = .02,具有多次测试校正。结果表明rs1128503处的基因型,总性功能障碍和女性使用PGP底物之间存在关系,这可能解释了选择性5-羟色胺再摄取抑制剂治疗所发现的某些性功能障碍变异性。结果需要用包括男性在内的更大样本量来确认。