BACKGROUND & AIMS:
:A number of prenylated phenols, mainly flavonoids, have been identified as active constituents of medicinal plants. Due to their beneficial effects on human health, this class of compounds has received a great deal of attention, not only from the pharmaceutical industry, but also from other areas of applied sciences, including the food, brewing, and cosmetics industries. The addition of prenyl residues through the activity of isoprenyltransferases, the key biosynthetic enzymes for these plant metabolites, endows flavonoids with a variety of biological activities, mostly due to improved interaction with membranes and proteins. The role of prenylated flavonoids in plants correlates with their activities as antioxidant or anti-infectious agents. In connection with these effects, these compounds have been evaluated for multiple potential uses, e.g. as antibacterial, antiprotozoal, antifungal, anti-inflammatory, antitumor, estrogenic, antidiabetic, or antithrombotic agents, among others. The present review, in principle focused on phenolic derivatives containing a non-cyclized isoprenyl chain, discusses the most relevant pharmacological reports for the period 2005-2012.
背景与目标:
: 许多异戊二烯化酚,主要是类黄酮,已被确定为药用植物的活性成分。由于它们对人类健康的有益影响,这类化合物不仅受到制药行业的关注,而且还受到应用科学领域的关注,包括食品,酿造和化妆品行业。通过异戊二烯基转移酶 (这些植物代谢物的关键生物合成酶) 的活性添加异戊二烯基残基,使类黄酮具有多种生物活性,这主要是由于与膜和蛋白质的相互作用得到改善。异戊二烯化类黄酮在植物中的作用与其作为抗氧化剂或抗感染剂的活性相关。与这些作用有关,这些化合物已被评估为多种潜在用途,例如作为抗菌,抗原生动物,抗真菌,抗炎,抗肿瘤,雌激素,抗糖尿病或抗血栓形成剂等。本综述原则上集中于含有非环化异戊二烯基链的酚类衍生物,讨论了2005-2012年期间最相关的药理学报道。