The potential effects of flavonoids, phenylethanoid and neolignan glycosides from the aerial parts of Verbascum salviifolium Boiss. were studied in the p-benzoquinone-induced writhing reflex, for the assessment of the antinociceptive activity, and in carrageenan- and PGE1-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced ear edema models in mice, for the assessment of the anti-inflammatory activity. Through bioassay-guided fractionation and isolation procedures ten compounds from the aqueous extract of the plant, luteolin 7-O-glucoside (1), luteolin 3'-O-glucoside (2), apigenin 7-O-glucoside (3), chrysoeriol 7-O-glucoside (4), beta-hydroxyacteoside (5), martynoside (6), forsythoside B (7), angoroside A (8), dehydrodiconiferyl alcohol-9'-O-beta-D-glucopyranoside (9) and dehydrodiconiferyl alcohol-9-O-beta-D-glucopyranoside (10), were isolated and their structures were elucidated by spectral techniques. Results have shown that 1, 2, 3 and 5 significantly inhibited carrageenan-induced paw edema at a 200 mg/kg dose, while 1, 2 and 5 also displayed anti-inflammatory activity against the PGE1-induced hind paw edema model. However, all the compounds showed no effect in the TPA-induced ear edema model. The compounds 1 and 2 also exhibited significant antinociceptive activity.

译文

在对苯醌诱导的扭体反射中研究了来自Verbascum salviifoium Boiss地上部分的类黄酮,苯乙醇和neolignan糖苷的潜在作用,以评估抗伤害感受活性,并在卡拉胶和PGE1-induced后爪水肿和12 O-tetradecanoyl-13-acetate (TPA) 诱导的小鼠耳水肿模型中,用于评估抗炎活性。通过生物测定指导的分馏隔离程序,从植物的水提取物中分离出十种化合物,木犀草素7-o-葡萄糖苷 (1),木犀草素3 '-O-葡萄糖苷 (2),芹菜素7-o-葡萄糖苷 (3),金黄醇7-o葡萄糖苷 (4),β-羟基葡萄糖苷 (5),martynoside (6),分离了连翘苷B (7),angoroside A (8),脱氢二硝基醇-9'-O-β-D-吡喃葡萄糖苷 (9) 和脱氢二硝基alcohol-9-O-beta-D-glucopyranoside (10),并通过光谱技术阐明了它们的结构。结果表明,1、2、3和5在200 mg/kg剂量下可显着抑制角叉菜胶引起的爪子水肿,而1、2和5也显示出对PGE1-induced后爪子水肿模型的抗炎活性。但是,所有化合物在TPA诱导的耳水肿模型中都没有效果。化合物1和2也表现出明显的抗伤害感受活性。

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