poliomyelitis 英 [,pəʊlɪəʊmaɪə'laɪtɪs; ,pɒlɪəʊ-] 美 [,polɪo,maɪə'laɪtɪs]
释 义 n. [内科] 脊髓灰质炎；[医] 小儿麻痹症
例 句 Poliomyelitis is an infectious disease that used to be the most common cause of paralysis inyoung people. 脊髓灰质炎是一种传染性疾病必须使用的最常见原因瘫痪在年轻的人。
作者： Mihnea Bostina
Picornaviruses are small, icosahedral, nonenveloped, positive-sense, single-stranded RNA viruses that form one of the largest and most important viral families. Numerous Picornaviridae members pose serious health or agricultural threats, causing diseases such as poliomyelitis, hepatitis A, or foot-and-mouth disease. The antigenic characterization of picornavirus capsids plays an important role in understanding the mechanism of viral neutralization and the conformational changes associated with genome release, and it can point to regions which can be targeted by small-molecule compounds to be developed as antiviral inhibitors. In a recent study, Cao and colleagues applied this strategy to hepatitis A virus (HAV) and used cryo-electron microscopy (cryo-EM) to characterize a well-conserved antigenic site recognized by several monoclonal antibodies. They further used computational approaches to identify a small-molecule drug with a strong inhibitory effect on cell attachment.