A comparison of the efficacy and safety of iopamidol-370 and iodixanol-320 in patients undergoing multidetector-row computed tomography.
在接受多排计算机断层扫描的患者中,iopamidol-370 和 iodixanol-320 的有效性和安全性的比较。

摘要

OBJECTIVES:To prospectively compare the effects on heart rate (HR) and contrast enhancement efficacy of iopamidol-370 and iodixanol-320 in contrast-enhanced, multidetector-row computed tomography (CE-MDCT).
METHODS:IMPACT is a multicenter, double-blind study involving 166 patients undergoing CE-MDCT of the liver (n = 121) or peripheral arteries (n = 45) randomized to receive equi-iodine doses (40 gI) of iopamidol-370 or iodixanol-320 intravenous at 4 mL/s. CE-MDCT was performed using 16-MDCT scanners according to predefined imaging protocols. HR was measured with the patient in the supine position before and continuously for 5 minutes after contrast medium administration. Mean and peak increases in HR and the proportion of subjects with predefined HR increases (>5 to 

译文

目的: 前瞻性比较 iopamidol-370 和 iodixanol-320 在增强、多排计算机断层扫描 (CE-MDCT) 中对心率 (HR) 和增强对比效果的影响。
方法: IMPACT 是一项多中心、双盲研究,涉及 166 名接受肝脏 CE-MDCT (n = 121) 或外周动脉 (n = 45) 的患者随机接受等碘剂量 (40 gI) 的 iopamidol-370 或 iodixanol-320 静脉注射 4 mL/s。根据预定义的成像协议,使用 16-MDCT 扫描仪进行 CE-MDCT。在给予对比剂之前和之后连续 5 分钟测量患者仰卧位的 HR。HR 的平均值和峰值增加以及预定义 HR 的受试者比例增加 (> 5 至

Iodixanol

神经 造影剂 治疗药物
概述  :  

碘克沙醇为非离子型等渗碘造影剂,具有不解离、不带电荷、渗透压低及血浆等渗等优点,较其他离子型及非离子型的碘造影剂不良反应发生率低,由于其安全性高,受到临床的广泛亲睐,也是高敏体质的首选药。据katayama 等报告,在日本一项涉及337 647 例样本的临床试验中,非离子型造影剂组的严重过敏反应发生率仅为0.04%。指征和剂量DSA数字减影:造影剂可根据情况适当稀释。剂量根据造影的部位而定,可用5~60 ml/次,呵多次造影,但总剂量不宜超过2 ml/kg。CT增强扫描:用于全身各系统和各脏

iodixanol

释    义   碘克沙醇

例    句   Conclusions: The rate of CIN in high risk pts undergoing cardiac angiography is comparable after administration of iopamidol-370 or iodixanol-320. 结论: 使用碘帕醇-370或碘克沙醇-320后,接受心血管造影术的高危患者中CIN发生率是相当的。

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