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Calcitonin

内分泌

关键词内分泌 治疗药物 蛋白质激素

词汇介绍

拓展阅读

解析

Calcitonin   英 /,kælsɪ'təʊnɪn/   美 /,kælsə'tonɪn/

释    义   n. [生化] 降血钙素(等于thyrocalcitonin)

例    句   Objective To investigate the role of substance P and calcitonin gene-related peptide in chronic urticaria patients. 目的研究血清中P物质和降钙素基因相关肽在慢性荨麻疹中的作用。

概述

降钙素是一种蛋白质激素,主要由人和其他哺乳动物合成和分泌,由甲状腺中的滤泡旁细胞(C细胞)分泌。降钙素的总体作用是当血液中的钙浓度高于正常值时降低其浓度,当磷水平超过正常水平时,它还会降低血液中的磷浓度。降钙素以几种方式降低血清钙浓度。含降钙素的药物通常作为可注射的溶液给药,但在过去的几十年中,它们也以鼻喷雾剂的形式提供。适应症①绝经后骨质疏松症;②骨炎畸形;③高钙血症。不良反应中枢神经系统表现为头痛,虚弱,头晕,感觉异常;心血管系统表现为胸部疼痛;呼吸系统表现为鼻出血,鼻腔刺激,鼻炎;消化

Thyroxin and calcitonin secretion into thyroid venous blood is regulated by pharyngeal mechanical stimulation in anesthetized rats复制标题

咽部机械刺激对麻醉大鼠甲状腺静脉血甲状腺素和降钙素分泌的调节作用

发表时间:2019-07-03

影响因子:3.3

作者: Kaori Iimura

期刊:J Physiol Sci

The autonomic nerve fbers’ distribution to widespread visceral organs contributes to the regulation of various physiological functions. Endocrine functions are not exceptional. These include catecholamine secretion from the adrenal medulla and estradiol secretion from the ovary, leading to changes depending on the eferent activity of the sympathetic adrenal or ovarian branches, respectively. The thyroid gland, a large endocrine organ attached to the larynx and the upper part of the trachea, receives innervation from sympathetic and parasympathetic thyroid branches derived from the cervical sympathetic trunks (CSTs) and the superior laryngeal nerve (SLN), respectively. Recently, we have shown, by stimulating at a supramaximal intensity the cut peripheral portion of either CSTs or SLNs, that the sympathetic (inhibitory efects) and parasympathetic (excitatory efects) eferent fbers antagonistically regulate the secretion of immunoreactive thyroxin (iT4), immunoreactive triiodothyronine (iT3), and immunoreactive calcitonin (iCT) from the thyroid gland, whereas the sympathetic nerve promotes the secretion of immunoreactive parathyroid hormone (iPTH) from the parathyroid gland. Furthermore, when intact SLNs were stimulated at lowcurrent intensity to selectively excite thick myelinated fbers, secretion of iT3, iT4, and iCT increased, but secretion of iPTH did not change; these responses were similar to those produced by stimulation of cut peripheral SLNs. The majority of myelinated fbers in the SLN are aferent fbers, and pre- and postganglionic autonomic eferent fbers are unmyelinated in rats. These fndings led us to hypothesize that excitation of sensory aferents in SLN may produce a refex increase in the eferent activity of the SLN parasympathetic thyroid branches to promote hormonal secretion into thyroid venous blood.

译文

自主神经纤维分布于广泛的内脏器官,有助于调节各种生理功能。内分泌功能并非例外。这些包括肾上腺髓质分泌的儿茶酚胺和卵巢分泌的雌二醇,分别导致交感的肾上腺或卵巢分支活动的改变。甲状腺是附着于喉和气管上部的大型内分泌器官,分别接受来自交感神经和副交感神经的甲状腺分支的支配,这些交感神经来自于颈交感神经干(CST)和喉上神经(SLN)。最近,我们已经显示出,通过以极大的强度刺激CSTs或SLNs的切开的外周部分,交感神经(抑制作用)和副交感神经(兴奋作用)产生的神经节律性调节免疫反应性甲状腺素(iT4),免疫反应性甲状腺素的分泌(iT3)和免疫反应性降钙素(iCT)来自甲状腺,而交感神经则促进了甲状旁腺分泌免疫反应性甲状旁腺激素(iPTH)。此外,当以低电流强度刺激完整的SLN以选择性刺激厚髓鞘纤维时,iT3,iT4和iCT的分泌增加,但iPTH的分泌却没有改变。这些反应类似于刺激切下的周围SLN产生的反应。 SLN中大多数髓鞘纤维是传入纤维,在大鼠中神经节前和节后自主神经传入纤维是无髓的。这些发现使我们假设,SLN感觉传递的兴奋可能会增加SLN副交感神经甲状腺分支的活动,从而促进激素分泌到甲状腺静脉血中,从而使refrex增加。