微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Allopurinol
Allopurinol

内分泌

关键词内分泌 治疗药物 肾结石治疗药物

词汇介绍

拓展阅读

解析

allopurinol   英 /,ælə(ʊ)'pjʊərɪnɒl/   美 /,ælo'pjʊrə,nɔl; ,ælo'pjʊrə,nol; ,ælo'pjʊrə,nɑl/

释    义   n. [药] 别嘌呤醇

例    句   In addition, the decrease in ambulatory BP was directly correlated with allopurinol treatment. 此外,持续测量血压的降低直接与别嘌呤醇治疗相关。

概述

别嘌呤醇用于治疗痛风和某些类型的肾结石。它还可用于预防接受癌症化疗的患者尿酸水平升高。由于从垂死的癌细胞中释放尿酸,这些患者可能具有增加的尿酸水平。别嘌呤醇通过减少人体产生的尿酸量起作用。这种药物一般选择口服,剂量通常每日一次或按医生指示。注意事项在服用别嘌呤醇之前,请告诉您的医生或药剂师您是否对它过敏,或者如果你有严重的反应,或者如果您有任何其他过敏症。本产品可能含有非活性成分,可能引起过敏反应或其他问题。请咨询您的药剂师了解更多详情。在使用这种药物之前,请告诉您的医生或药剂师您的病史,尤

Assessment of anti-nociceptive effect of allopurinol in a neuropathic pain Model复制标题

别嘌呤醇在神经病理性疼痛模型中抗伤害性作用的评估

发表时间:2019-10-01

影响因子:2.9

作者: Ahmad Safari Sultan Abad

期刊:Brain Res

Oxidative and nitrosative stress, as well as mitochondrial dysfunction, have been identified as key factors in the pathogenesis of neuropathic pain. In addition, it has been recognized that glia (microglia and astroglia) in CNS, not only act as supporting cells but also have function as essential factors in the pathogenesis of neuropathic pain. The purine nucleoside has neuromodulatory effects on pain transmission by actions on sensory nerve terminals and actions within the spinal cord. Immunomodulatory effects of adenosine have been studied through the activation of three subtypes A1, A2, and A3 receptors. Allopurinol and its active metabolite, oxypurinol, are potent inhibitors of xanthine oxidase (XO), the enzyme responsible for catalysing hypoxanthine to xanthine and uric acid. For decades, allopurinol has been used for the management of gout and conditions associated with hyperuricemia. This drug has shown therapeutic effects in some pathological states by decreasing oxidative stress. Allopurinol exhibits good penetration to CNS, and has shown beneficial effects in patients with a recent acute ischemic stroke through lowering inflammatory marker, intercellular adhesion molecule-1 levels. But Dawson et. al. (2009) found no protective effect of allopurinol. In other studies antinociception and adenosine mechanisms have been implicated in its actions. However, current findings in a neuropathic pain model are original. In this study, we evaluated anti-allodynic and anti-hyperalgesic effects of intraperitoneal allopurinol on the chronic constriction injury (CCI) model of neuropathic pain in rats. We sought to investigate possible pathways involved by measuring gene expression levels of inducible nitric oxide synthase (iNOS), an enzyme responsible for nitric oxide (NO) production, as well as programed cell death (apoptosis) regulating factors including bax, bcl2 and caspase 3. Furthermore, glial fibrillary acidic protein (GFAP) and ionized binding protein (Iba1) were measured as the indicators of astroglia and microglia activation, respectively. The role of adenosine receptors was evaluated using the A1 receptor antagonist, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), and non-selective receptor antagonist, theophylline.

译文

氧化和亚硝化应激以及线粒体功能障碍已被确定为神经性疼痛发病机制中的关键因素。此外,已经认识到CNS中的神经胶质细胞(小胶质细胞和星形胶质细胞)不仅起到支持细胞的作用,而且还在神经性疼痛的发病机理中具有作为必需因子的功能。嘌呤核苷通过对感觉神经末梢的作用和脊髓内的作用对疼痛传递具有神经调节作用。已经通过激活三种亚型A1,A2和A3受体来研究腺苷的免疫调节作用。别嘌呤醇及其活性代谢产物羟嘌呤醇是黄嘌呤氧化酶(XO)的有效抑制剂,XO是负责将次黄嘌呤催化成黄嘌呤和尿酸的酶。几十年来,别嘌呤醇已被用于治疗与高尿酸血症相关的痛风和病症。该药通过降低氧化应激在一些病理状态中显示出治疗效果。别嘌呤醇对CNS具有良好的渗透性,并且通过降低炎症标志物,细胞间粘附分子-1水平,对近期急性缺血性中风患者显示出有益效果。但道森等人。人。 (2009)发现别嘌呤醇没有保护作用。在其他研究中,抗伤害感受和腺苷机制与其作用有关。然而,神经性疼痛模型中的当前发现是原始的。在本研究中,我们评估了腹膜内别嘌呤醇对大鼠神经病理性疼痛的慢性压迫性损伤(CCI)模型的抗痛觉超敏和抗痛觉过敏作用。我们试图通过测量诱导型一氧化氮合酶(iNOS)的基因表达水平来研究可能的途径,iNOS是一种负责一氧化氮(NO)产生的酶,以及编程细胞死亡(凋亡)调节因子,包括bax,bcl2和caspase 3。此外,分别测量胶质纤维酸性蛋白(GFAP)和离子化结合蛋白(Iba1)作为星形胶质细胞和小胶质细胞激活的指标。使用A1受体拮抗剂1,3-二丙基-8-环戊基黄嘌呤(DPCPX)和非选择性受体拮抗剂茶碱来评价腺苷受体的作用。