微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Temozolomide
Temozolomide

内分泌

关键词内分泌 治疗药物 脑癌

词汇介绍

拓展阅读

解析

temozolomide

释    义   替莫唑胺

例    句   At recurrence temozolomide is effective for anaplastic tumors; well-tolerated and probably equally effective is PCV used as adjuvant therapy. 对于复发的病人,替莫唑胺对间变胶质瘤是有效的。作为辅助治疗,它和PCV 方案有同等的效果。

概述

替莫唑胺是一种口服化疗药物。它是一种烷化剂,用于治疗某些脑癌,作为星形细胞瘤的二线治疗和多形性胶质母细胞瘤的一线治疗。作用机制替莫唑胺的治疗益处取决于其烷基化/甲基化 DNA的能力,其最常发生在鸟嘌呤残基的N-7或O-6位置。这种甲基化会破坏DNA并引发肿瘤细胞的死亡。然而,一些肿瘤细胞能够修复这种类型的DNA损伤,因此通过O-6-甲基鸟嘌呤-DNA甲基转移酶表达人类编码的蛋白质O6-烷基鸟嘌呤DNA烷基转移酶(AGT),从而降低替莫唑胺的治疗效果。在一些肿瘤中,MGMT的表观遗传沉默基因阻

Whole brain radiotherapy with concurrent temozolomide in multifocal and/or multicentric newly diagnosed glioblastoma复制标题

同期替莫唑胺全脑放疗治疗多灶性和/或多中心性新诊断胶质母细胞瘤

发表时间:2019-10-10

影响因子:1.6

作者: L Lahmi

期刊:J CLIN NEUROSCI

Glioblastoma (GBM) is the most common primary malignant brain tumour in adults, with 3.55 new cases per 100,000 persons per year, adjusted to the European Standard Population. Despite intensive therapeutic options, GBM is a lethal disease associated with a median overall survival (OS) of less than 24 months. GBM appears as contrast-enhanced space-occupying lesions on magnetic resonance imaging (MRI) with irregular boundaries. Central necrosis and perilesional oedema are common. In 2005, a randomized controlled trial showed that radiation therapy (RT) and temozolomide (TMZ) prolonged OS. Since then, this approach has become the standard treatment for healthy adult patients with newly diagnosed GBM. A recent systemic review and meta-analyses stated that the incidence of solitary glioma is 81%. Other older studies showed that 20% of GBM patients had multiple lesions, described as two entities: multifocal and multicentric (M/M) gliomas. Batzdorf and Malamud defined multifocal GBM as a tumour disseminated along established CNS pathways such as white matter fibre tracts, cerebrospinal fluid, or local invasion; and multicentric glioma as widely separated in location and/ or time. The incidences of multifocal and multicentric (M/M) gliomas were 25.4% and 2.4%, respectively. Recent studies showed that M/M GBM cohorts had significantly poor OS compared to unifocal GBM (6 versus 11 months). Thus, M/M GBMs present one of the worst prognoses of GBMs. The management of such an extended disease is therefore a challenge for neurosurgeons and radiation oncologists. Two first line therapeutic options for treating M/M GBM, after biopsy or partial resection, are currently being implemented: long-term TMZ and radiotherapy (Focal or Whole brain). There are no guidelines regarding the optimal management of M/M GBM.

译文

胶质母细胞瘤(GBM)是成人中最常见的原发性恶性脑肿瘤,每年每100,000人中有3.55例新病例,根据欧洲标准人群进行调整。尽管有强烈的治疗选择,但GBM是一种致死性疾病,其中位总生存期(OS)不到24个月。 GBM表现为具有不规则边界的磁共振成像(MRI)上的对比度增强的占位性病变。中心坏死和周围水肿是常见的。 2005年,一项随机对照试验显示放射治疗(RT)和替莫唑胺(TMZ)延长了OS。从那时起,这种方法已成为新诊断的GBM健康成人患者的标准治疗方法。最近的系统综述和荟萃分析表明孤立性胶质瘤的发生率为81%。其他较早的研究表明,20%的GBM患者有多处病变,描述为两个实体:多灶性和多中心(M / M)胶质瘤。 Batzdorf和Malamud将多灶性GBM定义为沿着已确定的CNS途径传播的肿瘤,例如白质纤维束,脑脊液或局部侵袭;和多中心胶质瘤在位置和/或时间上分开。多焦点和多中心(M / M)胶质瘤的发生率分别为25.4%和2.4%。最近的研究表明,与单焦点GBM相比,M / M GBM队列的OS显着较差(6对11个月)。因此,M / M GBM是GBM最差的预测之一。因此,对这种扩展疾病的管理对于神经外科医生和放射肿瘤学家来说是一个挑战。目前正在实施两种治疗M / M GBM的一线治疗方案,即活检或部分切除术:长期TMZ和放射治疗(局灶性或全脑)。没有关于M / M GBM的最佳管理的指南。