内分泌
词汇介绍
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解析
Gout 英 /gaʊt/ 美 /ɡaʊt/
释 义 n. [遗][外科] 痛风;一滴;一团; n. (Gout)人名;(法)古
同根词 gouty adj. 痛风的;易患痛风的;患了痛风的
例 句 The pain of gout can arise suddenly and is often very intense. 痛风的疼痛可以突然出现,并往往是非常激烈的。
概述
概述
痛风是一种炎性关节炎,其特征是反复发作的红痛,灼热和肿胀的关节。疼痛通常很快发生,在不到12小时内达到最大强度。大约一半的情况下,大脚趾底部的关节受到影响。也可导致痛风石,肾结石,或尿酸性肾病。痛风是由于血液中尿酸水平持续升高,在高水平时,尿酸结晶,晶体沉积在关节,肌腱和周围组织中,导致痛风发作。痛风多发生在那些经常吃肉或海鲜,喝啤酒或超重的人身上。痛风的诊断可以通过关节液中或结晶液中存在晶体来确认,发作期间血尿酸水平可能正常。
临床表现
痛风可以以多种方式存在,尽管最常见的是急性炎症性关节炎(红痛,灼热,肿胀的关节)的反复发作。大脚趾底部的跖骨-趾骨关节受影响最大,占一半的病例。其他关节,如脚跟,膝盖,手腕和手指,也可能受到影响。关节疼痛通常在2-4小时和夜间开始。这主要是由于体温降低,其他症状可能很少伴有关节疼痛,包括疲劳和高烧。
长期升高的尿酸水平(高尿酸血症)可能会导致其他症状,包括皮肤坚硬,被称为尿酸结晶无痛沉积物性痛风石。广泛的痛风石可能导致骨质侵蚀而导致慢性关节炎。尿酸水平升高也可能导致肾脏结晶沉淀,导致结石形成和随后的尿酸盐肾病。
治疗方法
NSAIDs是痛风常用的一线治疗方法,可以在四小时内看到改善,建议治疗一到两周。不建议应用于那些患有某些其他健康问题的人,如胃肠道出血,肾功能衰竭或心力衰竭。虽然吲哚美辛在历史上一直是最常用的NSAID,但是布洛芬,可能是更优选的,对于那些有NSAIDs副作用风险的人,可以给予额外的质子泵抑制剂。有证据表明,COX-2抑制剂可与非选择性NSAID一起用于急性痛风发作,且副作用较少。
秋水仙碱是那些无法耐受NSAIDs的人的替代品。高剂量时,副作用(主要是胃肠不适)会限制其使用。在较低剂量仍然有效的情况下,它具有良好的耐受性。秋水仙碱可与其他常用的处方药相互作用,如阿托伐他汀和红霉素等。
已发现糖皮质激素与NSAIDs一样有效,如果NSAIDs存在禁忌症,可以使用糖皮质激素。当注入关节时,它们会改善相关症状。没有报告短期不良反应。
白细胞介素-1抑制剂,如canakinumab,对缓解疼痛和减少关节肿胀有中等效果,但增加了不良事件的风险,如背痛,头痛和血压升高等。然而,它们的效果可能不如常规剂量的NSAIDS。这类药物的高成本也阻碍了它们用于治疗痛风。
用户参与移动健康应用治疗痛风与改善自我护理行为之间的关联: 随机对照试验
发表时间:2019-08-13
影响指数:4.3
作者: Anna Serlachius
期刊:JMIR MHEALTH AND UHEALTH
This is the first study to examine the impact of a commercially available gout app on health outcomes. This is also the first study to examine the utility of a commercially available gout app from the patient’s perspective, by examining user engagement. Our primary hypothesis was largely confirmed by the findings, with the gout self-management app demonstrating higher user engagement scores than the dietary app. However, this did not translate to improvements in self-care behaviors. The findings regarding illness beliefs at follow-up were more mixed, with the gout self-management app associated with stronger consequence beliefs, illness identity beliefs, and emotional response beliefs than the dietary app. Several possible reasons exist to explain why higher user engagement did not translate to improvements in self-care behaviors. First, despite higher uMARS scores, there was no difference in time that participants spent on or used to access the gout app compared with the dietary app during the study. The average number of days spent using the app (of 14 days) for both groups was only 8. Both the apps in this study provided no feedback or goal-setting functions, thus requiring the user to be intentional about their app usage and access it without personalized feedback or any specific behavior change strategies. Second, as suggested by the participant feedback, it is possible that participants determined that the gout app (Gout Central) would only be helpful during a gout flare and thus used it less. This explanation may provide insight into why there was no difference in usage time between the two apps and no changes in self-care behaviors. Even though the gout app was chosen because it was the best available app for gout, it may not provide all the appropriate tools necessary to manage gout when it is asymptomatic. Therefore, Gout Central may not meet the needs of users in terms of continuous self-management and care of the condition between flares. A third possible explanation is that there was little integration with daily self-management behaviors in gout. Many existing health apps focus on providing educational content, basic health monitoring, or various reminders, but fail to fully utilize the unique capabilities of smartphone technology (eg, real-time data collection and data visualization technology). For gout, specifically, this may mean daily medication reminders, flare diaries, visualizing serum urate fluctuations, and food diary capabilities, which encourage a user to engage with their self-care regardless of whether they are having a flare. Real-time data tracking would be especially desirable for people who are testing their serum urate levels using commercially available test meters that provide an immediate result, which would then allow for real-time serum urate tracking. Even though the gout app provided a wealth of information about gout as well as some opportunities for data tracking, real-time reminders and real-time data tracking were both missing.
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