微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > hyperuricemic
hyperuricemic

内分泌

关键词内分泌 疾病 血液异常疾病

词汇介绍

拓展阅读

解析

hyperuricemic  

释    义   n. 血(内)尿酸过多的;高尿酸血症的

例    句   AIM: To clarify the relationship of serum uric acid and insulin resistance with first-phase islet secretion in hyperuricemic patients, and the factors that influence them. 目的:明确发生高尿酸血症患者胰岛素抵抗和胰岛第一分泌时相及其影响因素。

概述

高尿酸血症是指血液中存在异常高水平的尿酸。在体液的pH值条件下,尿酸主要以离子形式存在。体内尿酸盐的含量取决于食物中嘌呤的量,体内合成的尿酸盐量与排出的尿酸盐量之间是平衡的。在人类中,女性正常范围的上限为360 μmol/L(6mg/dL),男性为400 μmol/L(6.8 mg/dL)。许多因素导致高尿酸血症,包括遗传,胰岛素抵抗,铁超负荷,高血压,甲状腺机能减退,慢性肾病,肥胖,饮食,使用利尿剂(例如噻嗪类,袢利尿剂)和摄入过量的酒精饮料。其中,饮酒是最主要的原因。病理机制高尿酸血症的

Effects of ChondroT on potassium Oxonate-induced Hyperuricemic mice: downregulation of xanthine oxidase and urate transporter 1复制标题

软骨素对氧酸钾诱导的高尿酸血症小鼠的影响: 黄嘌呤氧化酶和尿酸转运蛋白1的下调

发表时间:2019-01-08

影响因子:2.5

作者: Dool-Ri Oh

期刊:BMC Complement Altern Med

In the present study, we demonstrated that ChondroT, a new complex herbal medication reduced serum UA in hyperuricemic mice by downregulating XOD activity and renal mURAT1. Because XOD and URAT1 are important targets to regulate hyperuricemia and gout, potassium oxonate-induced hyperuricemic mice were used as appropriate experimental models for investigating the mechanism underlying hyperuricemia. XOD plays an important role in the catabolism of purines. The XOD enzyme catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to UA. AP, an XOD inhibitor has been used as an anti-hyperuricemia agent and anti-gout In addition, febuxostat is a novel orally administered antihyperuricemic drug that reduces the production of UA in the body by XOD inhibition. We demonstrated that ChondroT inhibited XOD activity in vitro (Table 3). PO-treated mice can serve as a useful animal model for investigating hyperuricemia pathology. The intraperitoneal administration of 300 mg/kg PO for 7 days to mice increased the serum UA, decreased the urinary UA, and elevated the serum and liver XOD activity (Figs. 1 and 2). ChondroT significantly reduced the serum UA level, whereas it increased the urinary UA level in hyperuricemic mice (Fig. 1). Moreover, the ChondroT-treated mice showed a significant decreased in serum and liver XOD activity compared with that of the hyperuricemic mice (Fig. 2). Thus, the in vivo enzyme inhibitory activity of ChondroT is the net inhibitory activity of both XOD and xanthine dehydrogenase (XDH). Hyperuricemia is frequently observed in patients with chronic kidney disease and can be accompanied by an increase in serum Cr and BUN. Previous other studies reported that AP significantly blocked renal functional changes in PO-induced hyperuricemic rats and lowered Cr levels as well as UA in patients. We demonstrated that ChondroT significantly reduced the serum Cr and BUN levels in hyperuricemic mice (Table 4). Furthermore, liver dysfunction, poor blood flow in the liver and raised uric acid may cause hyperuricemia. In this study, PO-induced hyperuricemic mice increased liver damages by increasing the levels of two markers for liver damages, GOT, and GPT, which was attenuated by ChondroT and AP.

译文

在本研究中,我们证明了ChondroT,一种新的复合草药,通过下调XOD活性和肾脏mURAT1降低高尿酸血症小鼠的血清UA。由于XOD和URAT1是调节高尿酸血症和痛风的重要靶标,因此使用氧嗪酸钾诱导的高尿酸血症小鼠作为研究高尿酸血症机制的适当实验模型。 XOD在嘌呤的分解代谢中起重要作用。 XOD酶催化次黄嘌呤氧化成黄嘌呤,并可进一步催化黄嘌呤氧化成UA。 AP,一种XOD抑制剂已被用作抗高尿酸血症药和抗痛风此外,非布索坦是一种新型口服抗高尿酸药,通过XOD抑制减少体内UA的产生。我们证明了ChondroT在体外抑制XOD活性(表3)。 PO处理的小鼠可以作为研究高尿酸血症病理学的有用动物模型。向小鼠腹膜内施用300mg / kg PO 7天增加血清UA,降低尿UA,并升高血清和肝脏XOD活性(图1和2)。 ChondroT显着降低血清UA水平,而其增加高尿酸血症小鼠的尿UA水平(图1)。此外,与高尿酸血症小鼠相比,ChondroT处理的小鼠显示血清和肝脏XOD活性显着降低(图2)。因此,ChondroT的体内酶抑制活性是XOD和黄嘌呤脱氢酶(XDH)的净抑制活性。在患有慢性肾病的患者中经常观察到高尿酸血症,并且伴随着血清Cr和BUN的增加。之前的其他研究报道,AP显着阻断PO诱导的高尿酸血症大鼠的肾功能变化,并降低患者的Cr水平和UA。我们证明了ChondroT显着降低了高尿酸血症小鼠的血清Cr和BUN水平(表4)。此外,肝功能障碍,肝脏血流不畅和尿酸升高可能导致高尿酸血症。在这项研究中,PO诱导的高尿酸血症小鼠通过增加肝脏损伤,GOT和GPT两种标志物的水平来增加肝损伤,这些标志物被ChondroT和AP减弱。