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Pentose phosphate pathway

内分泌

关键词内分泌 临床研究术语 生化过程

词汇介绍

拓展阅读

解析

pentose   英 /'pentəʊz; -s/   美 /'pɛntos/

释    义   n. [有化] 戊糖

例    句   Another aldonic acid, gluconic acid, is an intermediate in the pentose phosphate pathway.另一个重要的醛酸,葡萄糖酸是戊糖磷酸途径的中间产物。

 

phosphate   英 /ˈfɒsfeɪt/   美 /ˈfɑːsfeɪt/

释    义   n. 磷酸盐;皮膜化成

例    句   Humans need a healthy diet and keeping the balance of phosphate in the diet may be important for a healthy life and longevity.研究人员表示:“人们需要健康的饮食,保持饮食中磷酸盐摄入的平衡可能对健康和长寿非常重要。

 

pathway   英 /ˈpɑːθweɪ/   美 /ˈpæθweɪ/

释    义   n. 路,道;途径,路径;神经通路

例    句   What's changing along here is the what's changing along this pathway is the expression pattern of genes in cells.因此这里改变的是,在这条途径上改变的是基因表达的模式

概述

戊糖磷酸途径是一种平行于糖酵解的代谢途径,它产生NADPH和戊糖(5-碳糖),以及核糖5-磷酸(核苷酸合成的前体)。虽然戊糖磷酸途径确实涉及葡萄糖的氧化,但其主要作用是合成代谢而非分解代谢。该途径在红细胞中尤其重要。该途径有两个不同的阶段:第一个是氧化相,在其中生成NADPH,第二个是5碳糖的非氧化合成。 作用机理 ①氧化相:在此阶段,两个分子NADP +被还原成NADPH,从转化利用能量葡萄糖-6-磷酸成核酮糖5-磷酸。整个反应

COMBINED METABOLIC AND TRANSCRIPTIONAL PROFILING IDENTIFIES PENTOSE PHOSPHATE PATHWAY ACTIVATION BY HSP27 PHOSPHORYLATION DURING CEREBRAL ISCHEMIA复制标题

结合代谢和转录谱确定脑缺血期间HSP27磷酸化的戊糖磷酸途径激活

发表时间:2017-05-04

影响因子:3.2

作者: Taichiro Imahori

期刊:Neuroscience

Stroke is estimated to be the second leading cause of death and the third most common cause of permanent disability worldwide. Ischemic stroke accounts for more than 90% of all strokes. However, the metabolic pathophysiology underlying ischemic stroke remains poorly understood. The development of high-throughput ‘‘omic” methods, such as  transcriptomics, which permits the screening of large numbers of genes for involvement in biological processes, has provided powerful tools for addressing complex issues related to human health. Metabolome analyses using omics methods have recently been reported. In this context, mass  spectrometry (MS) and nuclear  magnetic resonance (NMR) spectroscopy have garnered the most attention because of their ability to simultaneously profile a large number of metabolites. These technologies provide comprehensive information on thousands of low molecular mass compounds (less than 2 kDa), including lipids, amino acids, peptides, nucleic acids, organic acids, vitamins, thiols and carbohydrates. Metabolomics renders the metabolic profile of a system and the end points of biological events and reflects the state of a cell or a group of cells at a given time point. Gas-chromatography/mass-spectrometry (GC–MS) is one of the wide-spread techniques that enables researchers to determine analyte masses with high precision and accuracy, such that peptides and metabolites can be unambiguously identified even in complex fluids.

译文

据估计,中风是全球第二大死亡原因,也是第三大永久性残疾原因。缺血性中风占所有中风的90%以上。然而,对缺血性卒中的代谢病理生理学基础仍知之甚少。高通量“omic”方法的发展,如转录组学,允许筛选大量参与生物过程的基因,为解决与人类健康相关的复杂问题提供了强有力的工具。最近有报道用组学方法进行代谢组分析。在这一背景下,质谱(MS)和核磁共振(NMR)技术由于能够同时分析大量代谢物而备受关注。这些技术提供了关于数千种低分子量化合物(小于2kda)的全面信息,包括脂质、氨基酸、肽、核酸、有机酸、维生素、硫醇和碳水化合物。代谢组学描述一个系统的代谢情况和生物事件的终点,反映一个细胞或一组细胞在给定时间点的状态。气相色谱/质谱(GC-MS)是一种广泛应用的技术,它使研究人员能够以高精度和准确度测定分析物质量,从而即使在复杂的液体中也能清楚地识别肽和代谢物。