摘要

18F-Fluorodeoxyglucose (FDG)-positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging with background signal suppression (DWIBS) are 2 powerful functional imaging modalities in the evaluation of malignant plasma cell (PC) disease multiple myeloma (MM). Preliminary observations have suggested that MM patients with extensive disease according to DWIBS may be reported as being disease-free on FDG-PET ("PET false-negative"). The aim of this study was to describe the proportion of PET false-negativity in a representative set of 227 newly diagnosed MM patients with simultaneous assessment of FDG-PET and DWIBS, and to identify tumor-intrinsic features associated with this pattern. We found the incidence of PET false-negativity to be 11%. Neither tumor load-associated parameters, such as degree of bone marrow PC infiltration, nor the PC proliferation rate were associated with this subset. However, the gene coding for hexokinase-2, which catalyzes the first step of glycolysis, was significantly lower expressed in PET false-negative cases (5.3-fold change, P < .001) which provides a mechanistic explanation for this feature. In conclusion, we demonstrate a relevant number of patients with FDG-PET false-negative MM and a strong association between hexokinase-2 expression and this negativity: a finding which may also be relevant for clinical imaging of other hematological cancers.

译文

18f-氟脱氧葡萄糖 (FDG)-正电子发射断层扫描 (PET) 和带背景信号抑制的扩散加权磁共振成像 (DWIBS) 有 2 种强大的功能成像模式用于评价恶性浆细胞 (PC) 疾病多发性骨髓瘤 (MM)。初步观察表明,根据 DWIBS,患有广泛疾病的 MM 患者可能被报告为 FDG-PET 无病 (“PET 假阴性”)。本研究的目的是描述 PET 假阴性的比例在代表性的 227 个新诊断的 MM 患者中同时评估 FDG-PET 和 DWIBS, 并确定与该模式相关的肿瘤固有特征。我们发现 PET 假阴性的发生率为 11%。肿瘤负荷相关参数,如骨髓 PC 浸润程度和 PC 增殖率都与该子集无关。然而,催化糖酵解第一步的 hexokinase-2 基因编码在 PET 假阴性病例中表达明显较低 (5.3 倍变化,P <。 001) 这为这一特征提供了一个机械的解释。总之,我们证明了 FDG-PET 假阴性 MM 患者的相关数量,以及 hexokinase-2 表达和消极之间的密切联系: 这一发现也可能与其他血液肿瘤的临床成像相关。

Hexokinase

内分泌 糖类 临床研究术语
概述  :  

己糖激酶是一种酶的磷酸化的己糖(六碳糖),己糖形成磷酸盐。己糖激酶具有将无机磷酸基团从ATP转移至底物的能力。不应将己糖激酶与葡萄糖激酶混淆,后者是己糖激酶的特定同工型。所有的己糖激酶都能够使几种己糖磷酸化,但是葡萄糖激酶的底物亲和力降低了50倍,其主要的己糖底物是葡萄糖。己糖(例如葡萄糖)的磷酸化通常将其限制在许多细胞内代谢过程中,例如糖酵解或糖原合成。 哺乳动物己糖激酶的类型 有四种重要的哺乳动物己糖激酶同工酶(EC 2.7.1.1)

hexokinase   英 /,heksəu'kaineis/

释    义   n. [生化] 己糖激酶

例    句   Hexokinase (HXK) plays a important role in sugar signaling of plant cell.己糖激酶在植物细胞的信号转导中起着重要的作用。

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