Evaluation of Cholestyramine 15% Ointment in Relieving Pruritus and Burning After Ileostomy:A Rrandomized, Double-Blind Placebo-Controlled Clinical Trial 复制标题

15% 消胆胺软膏缓解回肠造口术后瘙痒和烧伤的评价: 随机、双盲、安慰剂对照临床试验

An ileostomy may be required for the management of different pathologic conditions. Anatomic location and the type of stoma construction can have significant effects on the management of this surgical procedure. The type and content of the output and the fluid loss are distinguished by the location of the stoma relative to the ileocecal valve. Fluid loss is primarily a factor with end or loop ileostomies. With proper stoma care, most ostomy patients can have active, healthy, personal, and professional lives. After an ileostomy, a special bag is put over the stoma to collect waste products. Although there has been much progress regarding the treatment of ileostomy so far, there are still many problems in this domain. The patient must be accustomed to the new patterns of fecal elimination, body change, and the image of him/herself. The most common early complications include skin irritation, pain, and necrosis. However, the most common late problems are skin irritation and prolapse. Even if an ileostomy is performed properly, the leakage of the intestinal discharge around the stoma can occasionally happen. This results in the initiation of troublesome skin irritation; therefore, the main complication is regarded as inflammation (e.g. irritant contact dermatitis), which presents by burning and pruritus. The inflammation appears to result from the high level of bile acid, which is present in the ileal fluid with powerful purifying and pruritogenic properties. Free bile acids have been proved to produce intestinal mucosal cell damage in laboratory animals .

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