摘要

Type 2 diabetes is characterized by decreases in insulin secretion and insulin sensitivity. Several classes of oral antidiabetic medications are currently approved for the treatment of type 2 diabetes. A stepwise treatment approach from monotherapy to combination therapy is traditionally used; however, the frequency of treatment failure with monotherapy has resulted in a move towards earlier treatment with combination therapies that target the two principal defects in glycaemic control. One such combination regimen is repaglinide (a prandial glucose regulator that increases insulin release) plus metformin (an insulin sensitizer that inhibits hepatic glucose output, increases peripheral glucose uptake and utilization and minimizes weight gain). Findings from several clinical trials have shown that combination therapy with repaglinide plus metformin is well tolerated and results in greater reductions of haemoglobin A(1c) and fasting plasma glucose values compared with either monotherapy. Repaglinide may also provide a more suitable alternative to combination therapy with sulphonylureas and metformin because of its reduced propensity for hypoglycaemia. The combination regimen of repaglinide plus metformin should therefore be considered as a valuable option in the management of patients with type 2 diabetes when monotherapy is no longer adequate.

译文

2 型糖尿病的特征是胰岛素分泌减少和胰岛素敏感性降低。几类口服抗糖尿病药物目前被批准用于治疗 2 型糖尿病。传统上使用从单一疗法到联合疗法的逐步治疗方法; 然而, 单一疗法治疗失败的频率导致了针对血糖控制的两个主要缺陷的联合疗法向早期治疗的转变。一个这样的联合方案是瑞格列奈 (一种增加胰岛素释放的膳食葡萄糖调节剂) 加上二甲双胍 (一种抑制肝脏葡萄糖输出、增加外周葡萄糖摄取和利用并将体重增加降至最低的胰岛素增敏剂)。几个临床试验的结果表明,与任何一种单一疗法相比,瑞格列奈联合二甲双胍的联合治疗耐受性良好,并导致血红蛋白 A (1c) 和空腹血糖值的更大降低。瑞格列奈还可能为磺酰脲和二甲双胍的联合治疗提供更合适的替代方案,因为其降低了低血糖的倾向。因此,当单一疗法不再足够时,瑞格列奈和二甲双胍的联合方案应该被认为是管理 2 型糖尿病患者的一个有价值的选择。

Repaglinide

内分泌 糖尿病 治疗药物
概述  :  

瑞格列奈是一种抗糖尿病药,称为美格替尼,于1983年发明,瑞格列奈是一种口服药物,除饮食和运动外,可用于控制2型糖尿病的血糖。瑞格列奈的作用机制涉及促进胰腺β胰岛细胞释放胰岛素。像其他抗糖尿病药一样,主要的副作用是低血糖症。机制瑞格列奈可通过刺激胰腺β胰岛细胞释放胰岛素来降低血糖,它通过关闭β细胞膜中ATP依赖性钾离子通道来实现,这使β细胞去极化,打开细胞的钙通道,并且所产生的钙内流诱导胰岛素分泌。吸收:瑞格列奈从胃肠道吸收时具有56%的生物利用度。与食物一起服用会降低生物利用度,最大浓度降

Repaglinide

释    义   瑞格列奈

例    句   Objective: To observe the clinical efficacy and safety of combined treatment of repaglinide and acarbose in aged patients with diabetes type 2. 目的:观察瑞格列奈、阿卡波糖联合治疗老年性2型糖尿病患者的临床疗效及安全性。

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