acromegaly cardiovascular risk diabetes medical therapy pegvisomant somatostatin analogs
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摘要

Diabetes mellitus is a frequent complication of acromegaly, a disease characterized by chronic hypersecretion of growth hormone (GH) by a pituitary adenoma. Diabetes occurs commonly but not only as a consequence of an insulin-resistant state induced by GH excess. The development of diabetes in patients with acromegaly is clinically relevant, since such a complication is thought to increase the already elevated cardiovascular morbidity and mortality risk of the disease. Emerging data suggest that a specific cardiomyopathy can be identified in acromegaly patients with diabetes. Moreover, the presence of diabetes may also influence therapeutic decision making in acromegaly, since traditional and newly developed drugs used in this clinical setting may impact glucose metabolism regardless of control of GH hypersecretion.

译文

糖尿病是肢端肥大症的常见并发症,肢端肥大症是一种以垂体腺瘤慢性分泌生长激素 (GH) 为特征的疾病。糖尿病通常发生,但不仅是由生长激素过量引起的胰岛素抵抗状态的结果。肢端肥大症患者糖尿病的发展与临床相关,因为这种并发症被认为会增加已经升高的心血管发病率和死亡风险。新出现的数据表明,在患有糖尿病的肢端肥大症患者中可以识别出一种特定的心肌病。此外,糖尿病的存在也可能影响肢端肥大症的治疗决策,因为在这种临床环境中使用的传统和新开发的药物可能会影响葡萄糖代谢,而不管 GH 高分泌的控制。

Acromegaly

内分泌 激素紊乱 疾病
概述  :  

肢端肥大症是一种激素紊乱,主要是由于体内过多的生长激素(GH)引起的。垂体是大脑中的小腺体,会产生GH,在肢端肥大症中,垂体产生过量的GH,通常,过量的GH来自垂体上的良性或非癌性肿瘤,这些良性肿瘤称为腺瘤。肢端肥大症最严重的后果是患2型糖尿病、高血压、心血管疾病和关节炎的风险增加。肢端肥大症患者的结肠息肉风险也增加,如果不切除,可能发展为结肠癌。临床表现肢端肥大症反映出其最常见的症状之一即手脚的异常生长。手和脚肿胀通常是早期特征,患者注意到戒指或鞋子的尺寸,特别是鞋子的宽度发生了变化。骨骼

acromegaly   英/,ækrə(ʊ)'megəlɪ/   美/,ækrə'mɛgəli/

释    义   n. [内科] 肢端肥大症

例    句   Human adults given growth hormone have suffered from acromegaly( excess bone growth) and carpal tunnel syndrome. 成年人给予生长激素,则会造成末端肥大(头过度生长)及腕管综合症。

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