Maximum androgen blockade using LHRH agonist buserelin in combination with short-term (two weeks) or long-term (continuous) cyproterone acetate is not superior to standard androgen deprivation in the treatment of advanced prostate cancer. Final analysis of EORTC GU Group Trial 30843. European Organization for Research and Treatment of Cancer (EROTC) Genito-Urinary Tract Cancer Cooperative Group.
使用 LHRH 激动剂 buserelin 联合短期 (两周) 或长期 (持续) 的最大雄激素阻断醋酸环丙孕酮在治疗晚期前列腺癌方面并不优于标准雄激素阻断。EORTC GU 集团试验 30843 的最终分析。欧洲癌症研究和治疗组织 (EROTC) 生殖-泌尿系统癌症合作小组。

摘要

This is the final analysis of EORTC GU Group Trial 30843 in which the treatment of advanced, metastatic prostate cancer with a combination of the LHRH agonist buserelin (nasal spray) and cyproterone acetate (Androcur), either continuously of only during the first 2 weeks, was compared with orchidectomy. There was no significant difference between the three arms as far as response rate, time to progression (subjective and objective) and duration of survival are concerned. Retrospective stratification according to the most important prognostic factors did not change the conclusions. Possible reasons for the difference with trial 30853, which used the same entry criteria but compared goserelin and flutamide with orchidectomy, are discussed. Reasons for using cyproterone acetate in combination treatment are the prevention of flare of the disease after LHRH agonists only and the prevention/reduction of toxicity in the form of hot flushes.

译文

这是 EORTC GU 小组试验 30843 的最终分析,其中使用 LHRH 激动剂 buserelin (鼻喷雾剂) 和醋酸环丙孕酮 (雄激素) 的组合治疗晚期转移性前列腺癌, 与兰花切除术相比,要么仅在头 2 周内连续进行。就反应率、进展时间 (主观和客观) 和生存时间而言,三组之间没有显著差异。根据最重要的预后因素进行回顾性分层没有改变结论。讨论了与试验 30853 不同的可能原因,该试验使用相同的进入标准,但将戈舍瑞林和氟他胺与兰花切除术进行了比较。在联合治疗中使用醋酸环丙孕酮的原因是仅在 LHRH 激动剂后预防疾病的爆发,以及以热潮红的形式预防/减少毒性。

Cyproterone

内分泌 内分泌 治疗药物
概述  :  

环丙孕酮,是一种甾体类抗雄激素药,在1960年代和1970年代进行了研究,但从未引入医学领域。这是一个模拟的醋酸环丙孕酮(CPA)、抗雄激素、孕激素、以及抗促性腺激素,环丙孕酮和CPA是最早开发的抗雄激素药与CPA不同,该药物从未销售过医疗用途。环丙孕酮是第一个被开发的纯抗雄激素,以及此类紧随其后的其他药物,包括甾体类抗雄激素贝诺酮和BOMT以及非甾体类抗雄激素氟他胺。环丙孕酮,也被称为1α,2α亚甲基-6-氯17α羟基δ6孕酮,是一种合成的孕激素和衍生物的孕酮,它是CPA 的游离醇或17α

Cyproterone   英/saɪ'prɑtə,ron/

释    义   n. 环丙孕酮

例    句   Objective To establish an accurate method for dissolution test of cyproterone acetate tablets. 目的建立准确测定复方醋酸环丙孕酮片溶出度的方法。

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