BACKGROUND & AIMS:
:Only 2 previous studies, conducted in Australia, United States and northern Europe, considered the role of dietary fibre intake on renal cell carcinoma (RCC) risk, and both showed a modest, inverse association. Therefore, we investigated in depth the topic of fibres and RCC, using data from a multicenter case-control study conducted in Italy from 1992 to 2004, including 767 cases with incident, histologically confirmed RCC and 1,534 controls admitted to the same network of hospitals as cases with acute nonmalignant conditions. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were obtained after allowance for major identified confounding factors, including total energy intake. The continuous OR for an increase in intake equal to the difference between the 80th and the 20th percentile were 0.94 (95% CI: 0.82-1.08) for total dietary fibre, 0.98 (95% CI: 0.85-1.13) for soluble noncellulose polysaccharides, 0.92 (95% CI: 0.80-1.05) for total insoluble fibre, 0.90 (95% CI: 0.78-1.04) for cellulose, 0.95 (95% CI: 0.84-1.06) for insoluble noncellulose polysaccharides and 1.06 (95% CI: 0.93-1.21) for lignin. With reference to the sources of fibre, we found an inverse association with vegetable fibre (OR = 0.84, 95% CI: 0.73-0.97), but no association with fruit (OR = 0.98, 95% CI: 0.86-1.12) and grain fibre (OR = 1.05, 95% CI: 0.95-1.15). The inverse association with vegetable fibre may reflect a real favorable effect, or be an indicator of a beneficial role of a diet rich in vegetable on RCC risk.
背景与目标:
:以前在澳大利亚,美国和北欧进行的两项研究仅考虑膳食纤维摄入对肾细胞癌(RCC)风险的作用,并且两者均显示出适度的逆相关性。因此,我们使用来自1992年至2004年在意大利进行的多中心病例对照研究的数据,深入研究了纤维和RCC的主题,其中包括767例经组织学证实为RCC的事件,并经与组织相同的医院网络接受了1,534例对照急性非恶性疾病的病例。在考虑到主要确定的混杂因素(包括总能量摄入)后,获得了多元比值比(OR)和95%置信区间(CI)。膳食总纤维的摄入量增加的连续OR等于第80个百分点与第20个百分点之间的差异,为0.94(95%CI:0.82-1.08),可溶性非纤维素多糖为0.98(95%CI:0.85-1.13),总不溶性纤维为0.92(95%CI:0.80-1.05),纤维素为0.90(95%CI:0.78-1.04),不溶性非纤维素多糖为0.95(95%CI:0.84-1.06)和1.06(95%CI:0.93) -1.21)为木质素。关于纤维的来源,我们发现与植物纤维呈负相关(OR = 0.84,95%CI:0.73-0.97),但与水果(OR = 0.98,95%CI:0.86-1.12)和谷物没有关联。纤维(OR = 1.05,95%CI:0.95-1.15)。与植物纤维的反向关联可能反映出真正的有利作用,或者表明富含蔬菜的饮食对RCC风险的有益作用。