BACKGROUND & AIMS:
:The aim of the research is to explore the relationship between hyperthyroidism, iodine, antithyroid drugs (propylthiouracil) and vascular endothelial injury. In total, 136 SD rats were randomly allocated into the control group, the hyperthyroidism group, the hyperthyroidism propylthiouracil group, the hyperthyroidism low iodine group, the high iodine group, and the endothelial injury group. Rats were raised for 60 days. Afterward, indicators concerning endothelial damage were determined, including the von Willebrand Factor (vWF), thrombomodulin (TM), nitric oxide (NO), endothelin 1 (ET-1), and P-selectin, as well as the plant hemagglutinin sample type oxidized low-density lipoprotein receptor 1 (LOX-1) from the aorta and the number of endothelial progenitor cells (EPCs) in whole blood. The hyperthyroidism group had significantly higher values for vWF, TM, NO, ET-1, and P-selectin in serum and a higher number of EPCs in whole blood compared with the control group, similar to the LOX-1 expression in abdominal aorta. The hyperthyroidism low iodine group had significantly higher values for vWF, ET-1, and P-selectin in serum and a higher number of EPCs in whole blood compared with those of the control group, as was the case for LOX-1 expression in the abdominal aorta. The hyperthyroidism propylthiouracil group had significantly higher values for FT4 in the serum compared with those in the control group. The electron microscope showed that hyperthyroidism caused a certain degree of endothelial injury to the abdominal aorta in rats. Hyperthyroidism can damage the vascular endothelium and is a high-risk factor for cardio-cerebrovascular disease. Propylthiouracil could be used in the treatment of hyperthyroidism, thus protecting endothelial cells from damage.
背景与目标:
:该研究的目的是探讨甲状腺功能亢进症,碘,抗甲状腺药(丙基硫尿嘧啶)与血管内皮损伤之间的关系。将总共136只SD大鼠随机分为对照组,甲状腺功能亢进组,甲状腺功能亢进丙硫氧嘧啶组,甲状腺功能亢进低碘组,高碘组和内皮损伤组。将大鼠饲养60天。之后,确定了有关内皮损伤的指标,包括血管性血友病因子(vWF),血栓调节蛋白(TM),一氧化氮(NO),内皮素1(ET-1)和P选择素,以及植物血凝素样品类型从主动脉中氧化的低密度脂蛋白受体1(LOX-1)和全血中内皮祖细胞(EPC)的数量。甲状腺功能亢进组与对照组相比,血清中的vWF,TM,NO,ET-1和P-选择素的值明显较高,全血中的EPC数量较高,与腹主动脉中的LOX-1表达相似。与对照组相比,甲亢低碘组的血清中vWF,ET-1和P-选择素的值明显高于对照组,全血中的EPC数量也高于对照组。腹主动脉。与对照组相比,甲亢性丙硫氧嘧啶组的血清FT4值明显更高。电子显微镜显示甲状腺功能亢进症对大鼠腹主动脉有一定程度的内皮损伤。甲状腺功能亢进会损害血管内皮,并且是心脑血管疾病的高危因素。丙硫氧嘧啶可用于治疗甲状腺功能亢进症,从而保护内皮细胞免受损害。