1. The effects of hyperthyroidism and hypothyroidism on the concentrations of glutamine and other amino acids in the muscle and plasma and on the rates of glutamine and alanine release from incubated isolated stripped soleus muscle of the rat were investigated. 2. Hyperthyroidism decreased the concentration of glutamine in soleus muscle but was without effect on that in the gastrocnemius muscle or in the plasma. Hyperthyroidism also increased markedly the rate of release of glutamine from the incubated soleus muscle. 3. Hypothyroidism decreased the concentrations of glutamine in the gastrocnemius muscle and plasma but was without effect on that in soleus muscle. Hypothyroidism also decreased markedly the rate of glutamine release from the incubated soleus muscle. 4. Thyroid status was found to have marked effects on the rate of glutamine release by skeletal muscle per se, and may be important in the control of this process in both physiological and pathological conditions.

译文

:1。研究了甲状腺功能亢进和甲状腺功能减退症对大鼠肌肉和血浆中谷氨酰胺和其他氨基酸的浓度以及从培养的分离的比目鱼比目鱼肌中谷氨酰胺和丙氨酸释放速率的影响。 2.甲状腺功能亢进降低比目鱼肌中谷氨酰胺的浓度,但对腓肠肌或血浆中的谷氨酰胺浓度没有影响。甲状腺功能亢进还显着增加了从比目鱼肌肉中释放谷氨酰胺的速率。 3.甲状腺功能减退症降低了腓肠肌和血浆中谷氨酰胺的浓度,但对比目鱼肌无影响。甲状腺功能减退症也显着降低了从比目鱼比目鱼肌释放谷氨酰胺的速率。 4.甲状腺状态被发现对骨骼肌本身释放谷氨酰胺的速率有显着影响,并且在生理和病理条件下对控制这一过程都可能很重要。

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