BACKGROUND & AIMS:
:Manual segmentation from magnetic resonance imaging (MR) is the gold standard for evaluating hippocampal atrophy in Alzheimer's disease (AD). Nonetheless, different segmentation protocols provide up to 2.5-fold volume differences. Here we surveyed the most frequently used segmentation protocols in the AD literature as a preliminary step for international harmonization. The anatomical landmarks (anteriormost and posteriormost slices, superior, inferior, medial, and lateral borders) were identified from 12 published protocols for hippocampal manual segmentation ([Abbreviation] first author, publication year: [B] Bartzokis, 1998; [C] Convit, 1997; [dTM] deToledo-Morrell, 2004; [H] Haller, 1997; [J] Jack, 1994; [K] Killiany, 1993; [L] Lehericy, 1994; [M] Malykhin, 2007; [Pa] Pantel, 2000; [Pr] Pruessner, 2000; [S] Soininen, 1994; [W] Watson, 1992). The hippocampi of one healthy control and one AD patient taken from the 1.5T MR ADNI database were segmented by a single rater according to each protocol. The accuracy of the protocols' interpretation and translation into practice was checked with lead authors of protocols through individual interactive web conferences. Semantically harmonized landmarks and differences were then extracted, regarding: (a) the posteriormost slice, protocol [B] being the most restrictive, and [H, M, Pa, Pr, S] the most inclusive; (b) inclusion [C, dTM, J, L, M, Pr, W] or exclusion [B, H, K, Pa, S] of alveus/fimbria; (c) separation from the parahippocampal gyrus, [C] being the most restrictive, [B, dTM, H, J, Pa, S] the most inclusive. There were no substantial differences in the definition of the anteriormost slice. This survey will allow us to operationalize differences among protocols into tracing units, measure their impact on the repeatability and diagnostic accuracy of manual hippocampal segmentation, and finally develop a harmonized protocol.
背景与目标:
: 磁共振成像 (MR) 的手动分割是评估阿尔茨海默氏病 (AD) 海马萎缩的金标准。尽管如此,不同的分段协议提供高达2.5倍的体积差异。在这里,我们调查了AD文献中最常用的分段协议,作为国际协调的第一步。解剖标志 (最前和最后切片,上、下、内侧和外侧边界) 是从12个已发表的海马手动分割协议中确定的 ([缩写] 第一作者,出版年份: [B] Bartzokis,1998; [C] Convit,1997; [dTM] deToledo-Morrell,2004; [·哈勒,1997; [·杰克,1994; [·基利亚尼,1993; [·勒赫里西,1994; [·米] 马利欣,2007; [·潘特尔,2000; [·普鲁斯纳,2000; [·苏尼宁,1994; 沃森,1992)。从1.5T MR ADNI数据库中提取的一名健康对照和一名AD患者的海马根据每个方案由单个评分者进行分割。通过单独的交互式网络会议,与协议的主要作者一起检查了协议的解释和实践翻译的准确性。然后提取语义上协调的地标和差异,涉及 :( a) 最后面的切片,协议 [B] 限制性最强,[H,M,Pa,Pr,S] 包容性最强; (b) 包含 [C,dTM,J,L,M,Pr,W] 或排除 [B,H,K,Pa,S] 的肺泡/菌毛; (c) 与海马旁回分离,[C] 限制性最强,[B,dTM,H,J,Pa,S] 包容性最强。最前切片的定义没有实质性差异。这项调查将使我们能够将协议之间的差异操作为跟踪单元,测量它们对手动海马分割的可重复性和诊断准确性的影响,并最终制定统一的协议。