Analysis of data derived from the Alzheimer's Disease Neuroimaging Initiative (ADNI) program showed plasma leptin levels in individuals with Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD) to be lower than those of subjects with normal cognition (NC). Approximately 70% of both men and women with MCI have plasma leptin levels lower than the median values of NC. Additionally, half of these subjects carry at least one apolipoprotein-E4 (APOE-ε4) allele. A subgroup of participants also had cerebrospinal fluid (CSF) leptin measured. Plasma leptin typically reflected the levels of leptin in CSF in all groups (Control/MCI/AD) in both genders. The data suggest that plasma leptin deficiency provides an indication of potential CNS leptin deficiency, further supporting the exploration of plasma leptin as a diagnostic marker for MCI or AD. The important question is whether leptin deficiency plays a role in the causation of AD and/or its progression. If this is the case, individuals with early AD or MCI with low plasma leptin may benefit from leptin replacement therapy. Thus, these data indicate that trials of leptin in low leptin MCI/early-stage AD patients should be conducted to test the hypothesis.

译文

对来自阿尔茨海默氏病神经影像倡议 (ADNI) 计划的数据进行的分析显示,患有轻度认知障碍 (MCI) 或阿尔茨海默氏病 (AD) 的个体的血浆瘦素水平低于具有正常认知 (NC) 的受试者。患有MCI的男性和女性中约有70% 的血浆瘦素水平低于NC的中值。此外,这些受试者中有一半携带至少一个apolipoprotein-E4 (APOE-ε4) 等位基因。一组参与者还测量了脑脊液 (CSF) 瘦素。血浆瘦素通常反映男女所有组 (对照组/MCI/AD) 中CSF中的瘦素水平。数据表明,血浆瘦素缺乏症提供了潜在的CNS瘦素缺乏症的指示,进一步支持血浆瘦素作为MCI或AD的诊断标志物的探索。重要的问题是瘦素缺乏症是否在AD的病因和/或其进展中起作用。如果是这种情况,患有早期AD或MCI且血浆瘦素低的个体可能会从瘦素替代治疗中受益。因此,这些数据表明,应该对低瘦素MCI/早期AD患者进行瘦素试验以检验这一假设。

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