BACKGROUND & AIMS:
:Since the eradication of smallpox approximately 39 years ago, monkeypox virus remains the most pathogenic poxvirus, being mainly restricted to Central and West Africa. Before 1970, there were no reports of human monkeypox in Nigeria, while between 1971 and 1978 there were three cases, with none having been reported thereafter. However, in September 2017, a case of contagious skin rash disease, typical of monkeypox, was observed in an 11-year-old boy from the southern part of the country and confirmed to be associated with the monkeypox virus. This large outbreak consisted of 262 suspected, 115 confirmed cases, and 7 mortalities across 26 states and the Federal Capital Territory (FCT), Abuja. The aim of this manuscript is to provide an updated, comprehensive, and timely review of monkeypox, an important emerging infection in Nigeria. Monkeypox is now a major threat to global health security, requiring an urgent multidisciplinary approach involving veterinarians, physicians, virologists, and public health experts to fast-track the development of diagnostic assays, vaccines, antivirals, and other control strategies.
背景与目标:
: 自从大约39年前消灭天花以来,猴痘病毒仍然是最具致病性的痘病毒,主要限于中部和西部非洲。1970年之前,尼日利亚没有人猴痘的报告,而1971年和1978则有3例,此后没有报告。然而,在2017年9月,在该国南部的一名11岁男孩中观察到传染性皮疹疾病,典型的猴痘,并证实与猴痘病毒有关。这次大规模爆发包括26个州和阿布贾联邦首都地区 (FCT) 的262个疑似病例,115个确诊病例和7个死亡病例。本手稿的目的是提供对猴痘 (尼日利亚一种重要的新兴感染) 的最新,全面和及时的回顾。猴痘现在是对全球健康安全的主要威胁,需要采取紧急的多学科方法,涉及兽医,医生,病毒学家和公共卫生专家,以快速跟踪诊断分析,疫苗,抗病毒药和其他控制策略的开发。