BACKGROUND & AIMS:
:Gastric cancer (GC) is a common disease with few effective treatment choices and poor prognosis, and has the second-highest mortality rates among all cancers worldwide. Dysregulation and/or malfunction of ion channels or aquaporins (AQPs) are common in various human cancers. Furthermore, ion channels are involved in numerous important aspects of the tumor aggressive phonotype, such as proliferation, cell cycle, apoptosis, motility, migration, and invasion. Indeed, by localizing in the plasma membrane, ion channels or AQPs can sense and respond to extracellular environment changes; thus, they play a crucial role in cell signaling and cancer progression. These findings have expanded a new area of pharmaceutical exploration for various types of cancer, including GC. The involvement of multiple ion channels, such as voltage-gated potassium and sodium channels, intracellular chloride channels, 'transient receptor potential' channels, and AQPs, which have been shown to facilitate the pathogenesis of other tumors, also plays a role in GC. In this review, an overview of ion channel and aquaporin expression and function in carcinogenesis of GC is presented. Studies of ion channels or AQPs will advance our understanding of the molecular genesis of GC and may identify novel and effective targets for the clinical application of GC.
背景与目标:
胃癌 (GC) 是一种常见疾病,有效的治疗选择少,预后差,在全球所有癌症中死亡率第二高。离子通道或水通道蛋白 (aqp) 的失调和/或故障在各种人类癌症中很常见。此外,离子通道参与肿瘤侵袭性声子类型的许多重要方面,例如增殖,细胞周期,凋亡,运动,迁移和侵袭。实际上,通过定位在质膜中,离子通道或aqp可以感知并响应细胞外环境的变化; 因此,它们在细胞信号传导和癌症进展中起着至关重要的作用。这些发现为包括GC在内的各种类型的癌症拓展了一个新的药物探索领域。多种离子通道的参与,例如电压门控钾和钠通道,细胞内氯离子通道,“瞬时受体电位” 通道和AQPs,已被证明可以促进其他肿瘤的发病,也在GC中起作用。本文综述了离子通道、水通道蛋白在GC癌变中的表达和功能。离子通道或AQPs的研究将促进我们对GC分子成因的理解,并可能为GC的临床应用确定新的有效靶标。