BACKGROUND & AIMS: BACKGROUND:Characterisation of risk groups who may benefit from pneumococcal vaccination is essential for the generation of recommendations and policy. METHODS:We reviewed the literature to provide information on the incidence and risk of invasive pneumococcal disease (IPD) in at-risk children in Europe and North America. The PubMed database was searched using predefined search terms and inclusion/exclusion criteria for papers reporting European or North American data on the incidence or risk of IPD in children with underlying medical conditions. RESULTS:Eighteen references were identified, 11 from North America and 7 from Europe, with heterogeneous study methods, periods and populations. The highest incidence was seen in US children positive for human immunodeficiency virus infection, peaking at 4167 per 100,000 patient-years in 2000. Studies investigating changes in incidence over time reported decreases in the incidence of IPD between the late 1990s and early 2000s. The highest risk of IPD was observed in children with haematological cancers or immunosuppression. Overall, data on IPD in at-risk children were limited, lacking incidence data for a wide range of predisposing conditions. There was, however, a clear decrease in the incidence of IPD in at-risk children after the introduction of 7-valent pneumococcal conjugate vaccine into immunisation programmes, as previously demonstrated in the general population. CONCLUSION:Despite the heterogeneity of the studies identified, the available data show a substantial incidence of IPD in at-risk children, particularly those who are immunocompromised. Further research is needed to determine the true risk of IPD in at-risk children, particularly in the post-PCV period, and to understand the benefits of vaccination and optimal vaccination schedules.

背景与目标： 背景：可能从肺炎球菌疫苗接种中受益的风险人群的表征对于产生建议和政策至关重要。
方法：我们回顾了文献，以提供有关欧洲和北美高危儿童的侵袭性肺炎球菌疾病（IPD）的发生率和风险的信息。使用预定义的搜索词和纳入/排除标准对PubMed数据库进行了搜索，以检索报告欧洲或北美患有基础疾病的儿童中IPD发生率或风险的数据。
结果：共确定了18篇参考文献，其中11篇来自北美，7篇来自欧洲，其研究方法，时期和人群各不相同。在人类免疫缺陷病毒感染呈阳性的美国儿童中发生率最高，在2000年达到峰值，每10万患者年中有4167名。调查随时间变化的研究报告说，在1990年代末至2000年代初，IPD发生率下降。在患有血液系统癌症或免疫抑制的儿童中，发生IPD的风险最高。总体而言，高危儿童的IPD数据有限，缺乏各种易患病情况的发病率数据。但是，将7价肺炎球菌结合疫苗引入免疫接种计划后，高危儿童IPD发生率明显下降，这在以前的一般人群中已得到证实。
结论：尽管已确定研究的异质性，但现有数据显示高危儿童，特别是免疫受损儿童的IPD发生率很高。需要进一步的研究来确定高危儿童中IPD的真正风险，尤其是在PCV后时期，并了解疫苗接种的好处和最佳的疫苗接种时间表。

BACKGROUND & AIMS: BACKGROUND AND OBJECTIVE:A variety of cytokines are involved in the incidence and development of bronchial asthma. This study was designed to reveal the relationship among genetic polymorphism of cytokine genes, expression levels of cytokines and incidence of bronchial asthma. METHODS:We analyzed 14 single nucleotide polymorphism loci in the 10 major cytokine genes plus plasma protein levels of 7 proteins in the bronchial asthma patients (n = 108) and the healthy population (n = 88) of the Han people in northern China. The polymorphism-based genotypes were identified by the sequence-specific primer-polymerase chain reaction. The plasma protein levels were determined by enzyme-linked immunoassay. Bioinformatics analysis was applied to further data processing. RESULTS:Data presented here showed that the 6 polymorphism loci were significantly correlated with the incidence of asthma (p < 0.05). Two of them, IL-2 (-330) and IL-2 (+166), constituted a linkage disequilibrium block. The GG haplotype of this block gave a relatively higher correlation with asthma (p = 0.0767). The plasma protein levels of IgE, IL-6 and IL-1 beta correlated with a number of polymorphism loci tested (p < 0.05), of which IgE gave the most significant correlation. The plasma IL-10 and IL-12 levels of the patients in the asthma group were significantly lower than those of the healthy adults in the control group (p < 0.05), while IgE gave the opposite result (p < 0.0001). We constructed a prototype of the metabolic and regulatory network composed of bronchial asthma-related proteins. In this network, IL-6 and TNF-alpha, were found with a high degree (D = 343 and 235, respectively) and IL-1beta with a moderate degree of connection (D = 155). CONCLUSIONS:We have found that various degrees of correlation with cytokine genes and protein expression of single nucleotide polymorphism in bronchial asthma. IL-6 and IL-1beta appear to play important biological roles in the pathogenesis of asthma. During the analysis of correlation between genetic polymorphism and a complex disease, the effects of environmental factors should be taken into account. The information at the protein level should be fully developed and the bioinformatics techniques can be used for the comprehensive analysis, to have a deep understanding of molecular mechanisms of incidence and development of diseases.

背景与目标： 背景与目的：多种细胞因子参与支气管哮喘的发生和发展。本研究旨在揭示细胞因子基因遗传多态性，细胞因子表达水平和支气管哮喘发生率之间的关系。
方法：我们分析了中国北方汉族支气管哮喘患者（n = 108）和健康人群（n = 88）中10个主要细胞因子基因的14个单核苷酸多态性位点以及7种蛋白的血浆蛋白水平。通过序列特异性引物-聚合酶链反应鉴定了基于多态性的基因型。通过酶联免疫测定法测定血浆蛋白水平。生物信息学分析被应用于进一步的数据处理。
结果：这里显示的数据表明6个多态性位点与哮喘的发生率显着相关（p <0.05）。 IL-2（-330）和IL-2（166）中的两个构成了连锁不平衡嵌段。该区域的GG单倍型与哮喘的相关性相对较高（p = 0.0767）。 IgE，IL-6和IL-1β的血浆蛋白水平与测试的多个多态性基因座相关（p <0.05），其中IgE的相关性最为显着。哮喘组患者的血浆IL-10和IL-12水平显着低于对照组健康成年人（p <0.05），而IgE则相反（p <0.0001）。我们构建了由支气管哮喘相关蛋白组成的代谢和调节网络的原型。在该网络中，发现IL-6和TNF-α的程度较高（分别为D = 343和235），而IL-1beta的连接程度为中等（D = 155）。
结论：我们发现支气管哮喘与细胞因子基因和单核苷酸多态性的蛋白质表达有不同程度的相关性。 IL-6和IL-1beta在哮喘的发病机理中似乎起着重要的生物学作用。在分析遗传多态性与复杂疾病之间的相关性时，应考虑环境因素的影响。应该充分开发蛋白质水平的信息，并可以使用生物信息学技术进行综合分析，以深刻理解疾病的发病和发展的分子机制。

BACKGROUND & AIMS: :A subsurface thermohaline front semi-permanently formed in association with near-bottom cyclonic circulation in the northern East China Sea was newly found from detailed hydrographic data collected during two cruises in February 2017 (winter) and April 2018 (spring) along with supplementary satellite remote sensing and historical hydrographic data. An alternate intruding frontal structure in water properties was observed across the cyclonic circulation in both seasons as formed by two contrasting water masses-low-temperature and low-salinity (i.e., low spiciness) water transported by the East China Sea Current and high-temperature and high-salinity (i.e., high spiciness) water transported by the Tsushima Warm Current. Consistent structures were confirmed from current observations during the two cruises, historical hydrographic observations, and satellite altimetry-derived sea surface height and surface frontal structure, indicative of retroflection of the Cheju Warm Current as deemed by the seasonal development of thermal stratification in spring. Our results reveal significant heat and material exchanges between the open Pacific and the broad shelf, particularly via diapycnal mixing and cross-front transports associated with across-front flow and cyclonic circulation, in the northern East China Sea.

背景与目标： ：在2017年2月（冬季）和2018年4月（春季）的两次航行中收集的详细水文数据中，新发现了与东海北部近底气旋循环半永久结合形成的地下热盐线前体。遥感和历史水文数据。在两个季节的整个气旋循环中，观察到了交替的侵入性锋面结构，这是由东海洋流和高温输送的两个相反的水团形成的，即低温和低盐度（即低辣度）水形成的。以及对马暖流输送的高盐度（即高辣度）水。两次航行中的当前观测，历史水文观测以及卫星测高仪得出的海面高度和表面锋面结构都证实了一致的结构，这表明了春季热分层的季节性发展表明了济州暖流的逆转。我们的研究结果揭示了东太平洋北部太平洋与大陆架之间存在大量的热和物质交换，特别是通过二叠氮混合和跨前沿流动和旋风循环相关的跨前沿运输。

BACKGROUND & AIMS: :This article surveys the botanical composition of 40 Muslim graveyards in northern Israel, accompanied by an ethnobotanical study of the folkloristic traditions of the use of these plants in cemeteries. Three groups of plants were found to be repeated systematically and were also recognized for their ritual importance: aromatics herbs (especially Salvia fruticosa and Rosmarinus officinalis), white flowered plants (mainly Narcissus tazetta, Urginea maritima, Iris spp. and Pancratium spp.) and Cupressus sempervirens as the leading cemetery tree. As endemic use we can indicate the essential role of S. fruticosa as the main plant used in all human rites of passage symbolizing the human life cycle. The rosemary is of European origin while the use of basil is of Indian influence. The use of white flowers as cemeteries plants reflects an old European influence and almost the same species are used or their congeners. Most of the trees and shrubs that are planted in Muslim cemeteries in Israel have the same use in ancient as well in modern European cultures. In conclusion, our findings on the occurrence of plants in graveyards reflect the geographic situation of Israel as a crossroads in the cultural arena between Asia and Europe. Most of the traditions are common to the whole Middle East showing high relatedness to the classical world as well as to the present-day Europe.

背景与目标： ：本文调查了以色列北部40个穆斯林墓地的植物学组成，并进行了民族植物学研究，研究了在墓地使用这些植物的民俗传统。发现三类植物可以系统地重复，并且在仪式上也很重要：芳香植物（特别是丹参和迷迭香），白花植物（主要是水仙，水母，虹膜和Pancratium。）和柏（Cupressus sempervirens）为领先的公墓树。作为特有的使用，我们可以指出金黄色葡萄球菌是在所有象征人类生命周期的人类通行仪式中使用的主要植物的重要作用。迷迭香是欧洲起源的，而罗勒的使用则具有印度的影响力。将白花用作墓地植物反映了欧洲的古老影响，几乎使用相同的物种或它们的同类。以色列穆斯林公墓中种植的大多数树木和灌木在古代和现代欧洲文化中都有相同的用途。总而言之，我们对墓地中植物生长的发现反映了以色列作为亚洲和欧洲之间文化交流的十字路口的地理状况。大多数传统是整个中东地区共有的，与古典世界以及当今的欧洲都息息相关。

BACKGROUND & AIMS: :Estimates of iron status in a random sample (218 men, 283 women) of the Northern Ireland population (aged 18-64 years) were obtained from blood measurements. Multiple criteria were used to determine Fe deficiency and body Fe stores were calculated as an index of Fe sufficiency. Three distinct groups with respect to Fe stores were identified on the basis of sex and menstrual status. Estimates of body Fe stores, mean (and SD), were 13.4 (SD 5.97), 5.3 (SD 6.09) and 8.5 (SD 6.72) mM for men, woman aged 18-44 years and women aged 45-64 years respectively. The prevalence of Fe-deficiency anaemia was low, ranging from 0.5% in men to 6.6% and 4.6% in the younger and older women respectively. The prevalence of Fe deficiency was low in men (1.4%) and older women (5.7%) rising to 11.0% in the younger group of women. The disproportionately elevated serum ferritin relative to transferrin saturation supported the suggestion that chronic inflammation might have influenced Fe status measurements in men and older women.

背景与目标： ：从血液测量中获得北爱尔兰人口（18-64岁）的随机样本（218例男性，283例女性）中铁的状况估计值。使用多个标准来确定铁缺乏症，并计算体内铁存储量作为铁充足性的指标。根据性别和月经状况，确定了关于铁存储的三个不同的类别。男性，18-44岁的女性和45-64岁的女性的体内铁存储量的平均值（和SD）分别为13.4（SD 5.97），5.3（SD 6.09）和8.5（SD 6.72）mM。缺铁性贫血的患病率很低，从男性的0.5％到年轻女性和老年女性的6.6％和4.6％。男性中铁缺乏症的患病率较低（1.4％），老年妇女中铁缺乏症的患病率（5.7％）上升至11.0％。相对于转铁蛋白饱和度而言，血清铁蛋白的升高不成比例地支持了这样的建议，即慢性炎症可能已经影响了男性和老年女性的铁状态测量。

BACKGROUND & AIMS: BACKGROUND:Knowledge, attitudes, and practices (KAP) surveys regarding zoonotic diseases are crucial to understanding the extent of knowledge among citizens and for guiding health-related education programs. METHOD:Employing a structured questionnaire, we interviewed residents (n = 388) in three districts of northern Tanzania (Karatu n = 128, Monduli n = 114, Babati n = 146) to assess knowledge, attitudes and reported practices regarding three zoonotic diseases that occur in the region (anthrax, brucellosis, and rabies). We used generalized linear mixed effects models and multi-model inference to identify demographic correlates of knowledge. RESULTS:Proportional average district- and disease- specific knowledge scores ranged from 0.14-0.61. We found positive correlations between age and knowledge of symptoms, causes and treatments of anthrax (three districts), brucellosis (three districts), and rabies (one district). Gender, ethnic identity, formal education and ownership of livestock or dogs had variable effects on knowledge among the interviewed population. Risk perceptions regarding different diseases varied across districts and were positively correlated with knowledge of the specific diseases. Direct interactions with livestock and domestic dogs were reported to occur across all demographic groups, suggesting that most people living in rural settings of our study area are potentially exposed to zoonotic diseases. Behaviors which may favor transmission of specific pathogens (such as consumption of raw milk or meat) were occasionally reported and varied by district. Wildlife was generally regarded as negative or neutral with regard to overall veterinary and human health. CONCLUSION:The combination of variable knowledge about zoonotic diseases in the three districts, reported occurrence of practices that are conducive to pathogen transmission, and previously documented circulation of pathogens causing anthrax, brucellosis and rabies in our study system, call for health education programs embedded in a holistic One Health approach.

背景与目标： 背景：关于人畜共患病的知识，态度和实践（KAP）调查对于理解公民之间的知识范围以及指导与健康相关的教育计划至关重要。
方法：采用结构化问卷，我们采访了坦桑尼亚北部三个地区的居民（n = 388），评估了三种人畜共患病的知识，态度和所报告的做法，这些知识涉及三种人畜共患病发生在该地区（炭疽，布鲁氏菌病和狂犬病）。我们使用广义线性混合效应模型和多模型推理来识别知识的人口统计相关性。
结果：地区和疾病特定知识的平均比例分数范围为0.14-0.61。我们发现年龄与症状知识，炭疽病（三个地区），布鲁氏菌病（三个地区）和狂犬病（一个地区）的知识，成因和治疗之间存在正相关。性别，种族身份，正规教育和牲畜或狗的所有权对受访者的知识产生了不同的影响。关于不同疾病的风险认知因地区而异，并且与特定疾病的知识呈正相关。据报道，在所有人口群体中，牲畜和家犬都有直接的相互作用，这表明大多数居住在我们研究区域农村地区的人都可能患有人畜共患病。偶尔报告了可能有利于特定病原体传播的行为（例如食用生牛奶或肉），并且各地区有所不同。在整个兽医和人类健康方面，野生生物通常被认为是消极的或中立的。
结论：结合三个地区对人畜共患疾病的可变知识，报告了有利于病原体传播的实践的发生以及先前在我们的研究系统中记录的导致炭疽，布鲁氏菌病和狂犬病的病原体的传播，呼吁建立健康教育计划一种整体的“一站式”治疗方法。

BACKGROUND & AIMS: :The language abilities of 42 8-year-old preterm children with birth weight < 1,750 g from a 1-year birth cohort in northern Finland was studied with four different language tests. Control children from the same birth cohort matched individually with their preterm pairs for age, sex, twinship, mother's education, place of residence, birth order and family type were also studied. In psycholinguistic test, auditory skills did not differ between the preterm and the full-term groups. Nor did any other linguistic subtest differentiate between the groups. Instead, the preterm children scored significantly poorer than their controls in visual subtests. The study also showed that the poor performance in visual tests was associated with neonatal morbidity, namely neonatal infections, need for continuous positive airway pressure (CPAP) treatment and patent ductus arteriosus (PDA). When studying the language abilities of preterm children, we suggest that qualitative methods should be used to analyse linguistic skills. We recommend versatile follow-up of preterm children until school age.

背景与目标： ：通过四个不同的语言测试，研究了芬兰北部1岁出生队列中42名8岁以下体重小于1750 g的早产儿的语言能力。还研究了来自同一出生队列的对照儿童，并分别对其年龄，性别，双胞胎，母亲的教育程度，居住地，出生顺序和家庭类型进行配对。在心理语言测试中，早产组和足额组之间的听觉技能没有差异。其他语言子测验也没有区分这两组。取而代之的是，早产儿在视觉子测验中的得分明显低于对照组。该研究还表明，视力检查的不良表现与新生儿发病率（即新生儿感染），持续持续气道正压通气（CPAP）治疗和动脉导管未闭（PDA）的发生有关。在研究早产儿的语言能力时，我们建议应使用定性方法来分析语言能力。我们建议对学龄前儿童进行多方面的随访，直到学龄前。

BACKGROUND & AIMS: INTRODUCTION:25 years ago was first reported in Cuba and in the western hemisphere an emergent disease: eosinophilic meningoencephalitis due to Angiostrongylus cantonensis larvae. AIM:To collect in a summary form the accumulated experience and the findings of the study of this parasitosis during the period in the Western hemisphere. DEVELOPMENT AND CONCLUSIONS:There have been collected the first evidences, the parasitological and malacological findings, the experimental and molecular studies on immunology and neuroimmunology, the clinic-pathological findings in children and adults with the particularities of this diseases in our environment with special emphasis in the never-before scientific findings reported. It has been documented the testimony, the main findings among the malacological studies, the role of the immunoglobulin E and the mechanism involved in the central nervous system, the intrathecal synthesis patterns of immunoglobulins and the clinical elements in children and adults.

背景与目标： 简介：25年前首次在古巴和西半球报道了一种新出现的疾病：由于广州管圆线虫幼虫引起的嗜酸性脑膜脑炎。
目的：以汇总的形式收集西半球时期该寄生虫病的积累经验和研究结果。
发展与结论：收集了第一批证据，寄生虫学和乳汁学发现，免疫学和神经免疫学的实验和分子研究，儿童和成人的临床病理学发现，特别是在我们环境中这种疾病的特殊性报告了前所未有的科学发现。已有证词，乳汁学研究的主要发现，免疫球蛋白E的作用和中枢神经系统的参与机制，免疫球蛋白的鞘内合成模式以及儿童和成人的临床要素的文献证明。

BACKGROUND & AIMS: BACKGROUND:The war in Syria has left millions struggling to survive amidst violent conflict, pervasive unemployment, and food insecurity. Although international assistance funding is also at an all-time high, it is insufficient to meet the needs of conflict-affected populations, and there is increasing pressure on humanitarian stakeholders to find more efficient, effective ways to provide assistance. OBJECTIVE:To evaluate 3 different assistance programs (in-kind food commodities, food vouchers, and unrestricted vouchers) in Idleb Governorate of Syria from December 2014 and March 2015. METHODS:The evaluation used repeated survey data from beneficiary households to determine whether assistance was successful in maintaining food security at the household level. Shopkeeper surveys and program monitoring data were used to assess the impact on markets at the district/governorate levels and compare the cost-efficiency and cost-effectiveness of transfer modalities. RESULTS:Both in-kind food assistance and voucher programs showed positive effects on household food security and economic measures in Idleb; however, no intervention was successful in improving all outcomes measured. Food transfers were more likely to improve food access and food security than vouchers and unrestricted vouchers. Voucher programs were found to be more cost-efficient than in-kind food assistance, and more cost-effective for increasing household food consumption. CONCLUSION:Continuation of multiple types of transfer programs, including both in-kind assistance and vouchers, will allow humanitarian actors to remain responsive to evolving access and security considerations, local needs, and market dynamics.

背景与目标： 背景：叙利亚战争使数百万人在暴力冲突，普遍失业和粮食不安全中艰难度日。尽管国际援助资金也达到了历史最高水平，但仍不足以满足受冲突影响的人口的需求，人道主义利益攸关方面临越来越大的压力，他们必须寻求更有效的方法来提供援助。
目的：自2014年12月至2015年3月，在叙利亚伊德尔布省评估3种不同的援助计划（实物食品，食品券和无限制券）。
方法：该评估使用了受益家庭的重复调查数据，以确定援助是否成功维持了家庭一级的粮食安全。店主调查和计划监测数据用于评估地区/政府层面对市场的影响，并比较转移方式的成本效益和成本效益。
结果：实物食品援助和优惠券计划均对伊德尔布的家庭粮食安全和经济措施产生了积极影响；但是，没有干预措施能够成功地改善所有测得的结果。与代金券和无限制代金券相比，粮食转移更有可能改善粮食获取和粮食安全。人们发现，优惠券计划比实物粮食援助更具成本效益，并且在增加家庭粮食消费方面更具成本效益。
结论：继续进行多种类型的转让计划，包括实物援助和凭证，将使人道主义行为体能够对不断变化的获取和安全考虑，当地需求以及市场动态做出响应。

BACKGROUND & AIMS: Objective:Characterize areas of interinstitutional cooperation and converging health agendas of the Pan American Health Organization/World Health Organization (PAHO/WHO), the Health Council of the Union of South American Nations (UNASUR), and the Amazon Cooperation Treaty Organization (ACTO) in South America based on social determinants of health. Methods:A qualitative study based on official documentary sources from the three organizations, using a comparative analysis of the health agendas of these agencies and the Rio Political Declaration on Social Determinants of Health (2011). Information was systematized using an analytical matrix that identifies convergences in the respective agendas. Results:Development of the health agendas of these agencies is influenced by various international forces such as Member States' foreign policy, international cooperation strategies and models, and the institutions' political and strategic guidelines. These agendas reveal efforts to strengthen blocs, cooperation mechanisms, and coordinated programmatic actions. Conclusions:The agendas of PAHO/WHO, the UNASUR Health Council, and ACTO point towards opportunities for convergence in various programmatic areas, emphasizing social determinants of health. Based on the overall agreements of the Rio Declaration as an analytical framework with recommendations in five decision-making spheres, structural cooperation actions can be carried out in the region's countries, jointly mediated by these agencies.

背景与目标： 目标：确定泛美卫生组织/世界卫生组织（PAHO / WHO），南美国家联盟卫生委员会（UNASUR）和亚马逊合作条约组织（ACTO）的机构间合作领域和融合卫生议程的特征在南美基于健康的社会决定因素。
方法：基于对这三个组织的卫生议程进行的比较分析以及对这三个组织的卫生议程的里约政治宣言（2011年）的定性研究，对这三个组织的卫生议程进行比较。信息通过分析矩阵系统化，该矩阵确定了各个议程中的趋同点。
结果：这些机构的卫生议程的制定受到各种国际力量的影响，例如会员国的外交政策，国际合作战略和模式以及机构的政治和战略指导方针。这些议程揭示了为加强集团，合作机制和协调的计划行动所做的努力。
结论：泛美卫生组织/世卫组织，UNASUR卫生理事会和ACTO的议程指出了在各个计划领域融合的机会，强调了健康的社会决定因素。根据《里约宣言》的总体协定作为一个分析框架，并在五个决策领域提出建议，在这些机构的共同推动下，可以在该区域各国采取结构性合作行动。

BACKGROUND & AIMS: :Composition and temporal variation of the microphytobenthos communities of the Conero Riviera (northern Adriatic Sea) were investigated in the course of an annual cycle, focusing on their relationships with blooms of the benthic dinoflagellate Ostreopsis cf. ovata. Sampling was carried out from March 2009 to March 2010 on undisturbed benthic substrata (macroalgae and pebbles). Samples for the study of microphytobenthos were collected with a monthly frequency, while those for the study of Ostreopsis bloom weekly. Benthic diatoms dominated the microphytobenthos communities for most of the annual cycle (except the summer), both in terms of abundance and biomass. In summer, cyanobacteria were dominant (54.04±9.18 and 24.29±11.11% of total abundance and biomass, respectively), while benthic dinoflagellates were an important component of the community in terms of biomass only at the peak of the Ostreopsis bloom in late summer (up to 91% of the total biomass). Among diatoms, the most abundant forms throughout the year were motile species (77.5±3.71% of the population), while erect diatoms formed the majority of the biomass in winter and spring (48.66±16.66 and 48.05±5.56% of total population, respectively). Diatoms were mainly affected by DIN availability, while the patterns of biomass of O. cf. ovata and cyanobacteria were related to salinity and temperature. The biomass of Ostreopsis was also affected by the availability of phosphorus. The results of this study suggest that the proliferation of Ostreopsis affected the structure of the benthic diatom community: motile diatoms were significantly more abundant during the Ostreopsis bloom peak than during the rest of summer, probably because they benefited from the abundant mucilaginous mat covering the benthic substrata. In the course of the O. cf. ovata bloom the diversity of the microphytobenthos was significantly lower than during the rest of the year, suggesting an influence of both the shading produced by the mucous mat and allelopathic compounds possibly produced by O. cf. ovata.

背景与目标： ：在一年周期的过程中，研究了Conero Riviera（北亚得里亚海）的微藻底栖动物群落的组成和时间变化，重点是它们与底鞭毛鞭毛藻（Ostreopsis）底栖生物开花的关系。卵子。从2009年3月至2010年3月对未受干扰的底栖基质（巨藻和卵石）进行了采样。每月收集用于研究微小藻类底栖动物的样品，而每周一次采集用于研究骨质疏松症的样品。在丰富度和生物量方面，底栖硅藻在整个年度周期的大部分时间（夏季除外）都主导着微型底栖动物群落。夏季，蓝藻占主导地位（分别占总丰度和生物量的54.04±9.18和24.29±11.11％），而底栖鞭毛藻仅在夏末Ostreopsis开花高峰时的生物量方面是群落的重要组成部分（高达总生物量的91％）。在硅藻中，全年最丰富的形态是游动物种（占人口的77.5±3.71％），而直立的硅藻在冬季和春季占生物量的大部分（分别占总人口的48.66±16.66和48.05±5.56％）。 ）。硅藻主要受DIN利用率的影响，而O.cf.的生物量模式。卵子和蓝细菌与盐度和温度有关。骨质疏松症的生物量也受到磷的有效性的影响。这项研究的结果表明，骨质增生症的增殖影响了底栖硅藻群落的结构：在动植物硅藻的盛花高峰期，活动硅藻比夏季其余时间明显丰富，这可能是因为它们受益于覆盖底栖生物的大量粘液性垫层。底层。在O的过程中。卵子花的微藻底栖动物的多样性明显低于该年的其余时间，这表明粘液垫产生的阴影和O.cf.可能产生的化感化合物的影响。卵子。

BACKGROUND & AIMS: :A conceptual framework is presented, expressing the relationship between food availability and the food and nutritional status of a population. As element of the model, the generation and transfer of appropriate food technologies were included. Based on the conceptual framework, three successful cases of food technology transfer in the Central American area were analyzed. The most important aspects of each case were identified, and a critical review of the characteristics and conditions required to generate and transfer appropriate technologies, was carried out. An inventory was made of those factors which are essential for a food technology to be appropriate; this analysis resulted in the postulation of a model describing the life cycle of appropriate food technologies. On these bases, several guidelines are postulated, which could constitute a conceptual framework to help guide actions in the generation and transference of appropriate food technologies in Central America and Panama. Essential elements of the proposed framework are: identification and characterization of the problem of the group of "users" of the technology; problem solution by a multidisciplinary group; test of the technology and evaluation of its feasibility (technical, economical, political, social and cultural), and controlled transference to the group of "users".

背景与目标： ：提出了一个概念框架，表达了粮食供应与人口粮食和营养状况之间的关系。作为模型的组成部分，包括了适当食品技术的产生和转让。在概念框架的基础上，分析了中美洲地区成功进行食品技术转让的三个案例。确定了每个案例的最重要方面，并对产生和转让适当技术所需的特征和条件进行了严格审查。对适当的食品技术必不可少的那些因素进行了盘点；该分析得出了描述适当食品技术生命周期的模型的假设。在此基础上，提出了几项准则，这些准则可以构成一个概念框架，以帮助指导中美洲和巴拿马有关适当食品技术的产生和转让的行动。拟议框架的基本要素是：确定和表征技术“用户”群体的问题；多学科小组的问题解决方案；测试技术并评估其可行性（技术，经济，政治，社会和文化），并控制向“用户”组的转移。

BACKGROUND & AIMS: BACKGROUND:Enterotoxigenic E. coli (ETEC) significantly contribute to diarrhea in piglets and weaners. The smallholder pig producers in Uganda identified diarrhea as one of the major problems especially in piglets. The aim of this study was to; i) characterize the virulence factors of E. coli strains isolated from diarrheic and non-diarrheic suckling piglets and weaners from smallholder herds in northern and eastern Uganda and ii) identify and describe the post-mortem picture of ETEC infection in severely diarrheic piglets. Rectal swab samples were collected from 83 piglets and weaners in 20 herds and isolated E. coli were characterized by PCR, serotyping and hemolysis. RESULTS:The E. coli strains carried genes for the heat stable toxins STa, STb and EAST1 and adhesins F4 and AIDA-I. The genes for the heat labile toxin LT and adhesins F5, F6, F18 and F41 were not detected in any of the E. coli isolates. Where the serogroup could be identified, E. coli isolates from the same diarrheic pig belonged to the same serogroup. The prevalence of EAST1, STb, Stx2e, STa, AIDA-I, and F4 in the E. coli isolates from suckling piglets and weaners (diarrheic and non-diarrheic combined) was 29, 26.5, 2.4, 1.2, 16, and 8.4 %, respectively. However the prevalence of F4 and AIDA-I in E. coli from diarrheic suckling piglets alone was 22.2 and 20 %, respectively. There was no significant difference in the prevalence of the individual virulence factors in E. coli from the diarrheic and non-diarrheic pigs (p > 0.05). The main ETEC strains isolated from diarrheic and non-diarrheic pigs included F4/STb/EAST1 (7.2 %), F4/STb (1.2 %), AIDA/STb/EAST1 (8 %) and AIDA/STb (8 %). At post-mortem, two diarrheic suckling piglets carrying ETEC showed intact intestinal villi, enterocytes and brush border but with a layer of cells attached to the brush border, suggestive of ETEC infections. CONCLUSION:This study has shown that the F4 fimbriae is the most predominant in E. coli from diarrheic piglets in the study area and therefore an F4-based vaccine should be considered one of the preventive measures for controlling ETEC infections in the piglets in northern and eastern Uganda.

背景与目标： 背景：产肠毒素大肠埃希菌（ETEC）显着促进仔猪和断奶仔猪的腹泻。乌干达的小农户养猪者认为腹泻是主要问题之一，特别是在仔猪中。这项研究的目的是： i）表征从乌干达北部和东部的腹泻和非腹泻哺乳仔猪和断奶仔猪断奶的大肠杆菌菌株的毒力因子，并且ii）识别并描述严重腹泻仔猪ETEC感染的死后图像。从20个猪群的83头仔猪和断奶仔猪中收集直肠拭子样品，并通过PCR，血清分型和溶血对分离出的大肠杆菌进行表征。
结果：大肠杆菌菌株携带了热稳定毒素STa，STb和EAST1以及粘附素F4和AIDA-1的基因。在任何大肠杆菌分离物中均未检测到热不稳定毒素LT和粘附素F5，F6，F18和F41的基因。在可以鉴定血清群的地方，来自同一腹泻猪的大肠杆菌分离物属于同一血清群。 EAST1，STb，Stx2e，STa，AIDA-1和F4在来自乳猪和断奶仔猪（腹泻和非腹泻的组合）的大肠杆菌分离物中的患病率分别为29％，26.5％，2.4％，1.2％，16％和8.4％ ， 分别。然而，仅腹泻型乳猪在大肠杆菌中F4和AIDA-1的患病率分别为22.2％和20％。腹泻和非腹泻猪的大肠杆菌中单个毒力因子的患病率均无显着差异（p> 0.05）。从腹泻和非腹泻猪分离出的主要ETEC株包括F4 / STb / EAST1（7.2％），F4 / STb（1.2％），AIDA / STb / EAST1（8％）和AIDA / STb（8％）。验尸时，两只携带ETEC的腹泻乳猪表现出完整的肠绒毛，肠上皮细胞和刷状缘，但附着在刷状缘上有一层细胞，提示是ETEC感染。
结论：这项研究表明，在研究区域腹泻仔猪中，F4菌群是大肠杆菌中最主要的，因此基于F4的疫苗应被视为控制北部和南部仔猪ETEC感染的预防措施之一。乌干达东部。

BACKGROUND & AIMS: -2

背景与目标： -2

BACKGROUND & AIMS: :Neurologists are interested in understanding whether patients with multiple sclerosis (pwMS) undergoing immunomodulatory/immunosuppressive therapy are more susceptible to developing COVID-19 or have worse outcomes. Currently, there are no conclusive data in this regard. We report the prevalence and severity of COVID-19 (confirmed and possible) in pwMS followed at the Veneto Regional MS Center in Verona (Italy), an area most stricken by COVID-19. In our sample size, the prevalence of COVID-19 seems to be much higher than that officially reported at the regional level on the general population, but it also characterized by a favourable course.

背景与目标： 神经学家对了解正在接受免疫调节/免疫抑制治疗的多发性硬化症（pwMS）患者更容易发展为COVID-19还是预后更差感兴趣。当前，在这方面没有确切的数据。我们报告了pwMS中COVID-19的患病率和严重程度（已确认并可能），随后在意大利维罗纳的威尼托地区MS中心（该地区受COVID-19打击最严重）。在我们的样本量中，COVID-19的患病率似乎比一般人群在区域级别上正式报告的要高得多，但是它的特点是发展过程良好。