Oral cancer is a neoplasm with some known causes. Proliferation genes are significant among its few pathogenetic and prognostic factors. Calcyclin is a cell-cycle-related gene, the function of which is still unclear. Its expression and that of Haras and histone-H3 have been investigated in an assessment of their pathogenetic role in squamous cell carcinoma. RNA extracted from the pathological and normal mucosa of patients with squamous cell carcinoma (SCC) and benign lesions was reverse transcribed and amplified by the polymerase chain reaction (PCR). The expression of all three genes in the pathological mucosa was enhanced in SCC only. This suggests that they may be involved in its pathogenesis and provides another parameter for the differentiation of malignant and benign lesions.

译文

:口腔癌是一种具有某些已知原因的肿瘤。增生基因在其少数致病和预后因素中很重要。钙环蛋白是与细胞周期相关的基因,其功能尚不清楚。为了评估它们在鳞状细胞癌中的致病作用,已经研究了它的表达以及Haras和组蛋白H3的表达。从鳞状细胞癌(SCC)和良性病变的病理和正常粘膜中提取的RNA通过聚合酶链反应(PCR)进行逆转录和扩增。仅在SCC中,病理黏膜中所有三个基因的表达均得到增强。这表明它们可能参与其发病机理,并为区分恶性和良性病变提供了另一个参数。

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