BACKGROUND:Malaria remains a public health issue, particularly in sub-Saharan Africa with special features of seriousness in young children and pregnant women. Adolescents and adults are reported to have acquired a semi-immune status and, therefore, present with low parasitaemia. Children are understood to present with a much higher parasitaemia and severe malaria. It is a concern that effective malaria control programmes targeting young children may lead to a delay in the acquisition of acquired immunity and, therefore, causing a shift in the epidemiology of malaria. Prevalence and parasitaemia were explored in adolescents and adults with Plasmodium falciparum infections compared to young children in the area of Lambaréné, Gabon as an indicator for semi-immunity.
METHODS:A cross-sectional study was conducted at the Centre de Recherches Médicales de Lambaréné (CERMEL) during a 6-month period in 2018. Symptomatic patients, of all ages were screened for malaria at health facilities in Lambaréné and Fougamou and their respective surrounding villages in the central region of Gabon. Plasmodium falciparum infections were determined either by rapid diagnostic test (RDT) or by microscopy. Descriptive analysis of data on parasite densities, anaemia, and fever are presented.
RESULTS:1589 individuals screened were included in this analysis, including 731 (46%) adolescents and adults. Out of 1377 assessed, the proportion of P. falciparum positive RDTs was high among adolescents (68%) and adults (44%), compared to young children (55%) and school children (72%). Out of 274 participants assessed for malaria by microscopy, 45 (16%) had a parasite count above 10,000/µl of which 9 (20%) were adults.
CONCLUSION:This study shows a high rate of P. falciparum infections in adolescents and adults associated with high-level parasitaemia similar to that of young children. Adolescents and adults seem to be an at-risk population, suggesting that malaria programmes should consider adolescents and adults during the implementation of malaria prevention and case management programmes with continuous care, since they also act as reservoirs for P. falciparum.
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【Description of Plasmodium falciparum infections in central Gabon demonstrating high parasite densities among symptomatic adolescents and adults.].
【加蓬中部恶性疟原虫感染的描述表明，有症状的青少年和成年人中寄生虫的密度很高。】
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DOI：10.1186/s12936-019-3002-9文章类型：杂志文章
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背景：疟疾仍然是一个公共卫生问题，尤其是在撒哈拉以南非洲地区，在幼儿和孕妇中具有严重的严重特征。据报告，青少年和成年人具有半免疫状态，因此寄生虫血症低。据了解，儿童患寄生虫病和严重疟疾的比例更高。令人关注的是，针对幼儿的有效疟疾控制计划可能会导致获得性免疫力获得延迟，从而导致疟疾流行病学发生转变。在加蓬的Lambaréné地区，与青少年相比，恶性疟原虫感染的青少年和成年人的患病率和寄生虫血症被发现是半免疫指标。
方法：2018年在Lambaréné的RecherchesMédicalesdeLambaréné中心（CERMEL）进行了横断面研究。在Lambaréné和Fougamou的医疗机构及其周围地区对所有年龄段的有症状患者进行了疟疾筛查。加蓬中部地区的村庄。通过快速诊断测试（RDT）或显微镜检查来确定恶性疟原虫感染。介绍了对寄生虫密度，贫血和发烧数据的描述性分析。
结果：1589名被筛选的人被纳入该分析，包括731名（46％）青少年和成人。在评估的1377例中，青少年（68％）和成人（44％）中恶性疟原虫阳性RDT的比例较高，而幼儿（55％）和小学生（72％）较高。在通过显微镜评估为疟疾的274名参与者中，有45名（16％）的寄生虫计数高于10,000 / µl，其中9名（20％）是成年人。
结论：这项研究表明，青少年和成年人中恶性疟原虫的感染率很高，与幼童的寄生虫血症相似。青少年和成年人似乎是处于危险中的人群，这表明疟疾规划在实施疟疾预防和病例管理方案时应考虑青少年和成年人，并对其进行持续护理，因为它们也可作为恶性疟原虫的宿主。
方法：2018年在Lambaréné的RecherchesMédicalesdeLambaréné中心（CERMEL）进行了横断面研究。在Lambaréné和Fougamou的医疗机构及其周围地区对所有年龄段的有症状患者进行了疟疾筛查。加蓬中部地区的村庄。通过快速诊断测试（RDT）或显微镜检查来确定恶性疟原虫感染。介绍了对寄生虫密度，贫血和发烧数据的描述性分析。
结果：1589名被筛选的人被纳入该分析，包括731名（46％）青少年和成人。在评估的1377例中，青少年（68％）和成人（44％）中恶性疟原虫阳性RDT的比例较高，而幼儿（55％）和小学生（72％）较高。在通过显微镜评估为疟疾的274名参与者中，有45名（16％）的寄生虫计数高于10,000 / µl，其中9名（20％）是成年人。
结论：这项研究表明，青少年和成年人中恶性疟原虫的感染率很高，与幼童的寄生虫血症相似。青少年和成年人似乎是处于危险中的人群，这表明疟疾规划在实施疟疾预防和病例管理方案时应考虑青少年和成年人，并对其进行持续护理，因为它们也可作为恶性疟原虫的宿主。
