BACKGROUND & AIMS:
:Two abietane diterpenes were isolated from cyanobacteria Microcoleous lacustris, 20-nor-3alpha-acetoxyabieta-5,7,9,11,13-pentaene and 20-nor-3alpha-acetoxy-12-hydroxy-abieta-5,7,9,11,13-pentaene. These compounds were assayed against Staphylococcus aureus, Staphylococcus epidermidis, Salmonella typhi, Vibrio cholerae, Bacillus subtilis, Bacillus cereus, Escherichia coli, and Klebsiella pneumoniae. Both compounds showed activity against S. aureus, S. epidermidis, S. typhi, and V. cholerae, but not against the other bacteria.
背景与目标:
: 从蓝藻微囊藻,20-nor-3alpha-acetoxyabieta-5,7,9、11、13-戊烯和20-nor-3alpha-acetoxy-12-hydroxy-abieta-5,7,9、11、13-戊烯中分离出两种阿比烷二萜。对这些化合物进行了金黄色葡萄球菌,表皮葡萄球菌,伤寒沙门氏菌,霍乱弧菌,枯草芽孢杆菌,蜡样芽孢杆菌,大肠杆菌和肺炎克雷伯菌的检测。两种化合物均显示出对金黄色葡萄球菌,表皮葡萄球菌,伤寒链球菌和霍乱弧菌的活性,但对其他细菌却没有。