Delineation of large-scale functional networks (FNs) from resting state functional MRI data has become a standard tool to explore the functional brain organization in neuroscience. However, existing methods sacrifice subject specific variation in order to maintain the across-subject correspondence necessary for group-level analyses. In order to obtain subject specific FNs that are comparable across subjects, existing brain decomposition techniques typically adopt heuristic strategies or assume a specific statistical distribution for the FNs across subjects, and therefore might yield biased results. Here we present a novel data-driven method for detecting subject specific FNs while establishing group level correspondence. Our method simultaneously computes subject specific FNs for a group of subjects regularized by group sparsity, to generate subject specific FNs that are spatially sparse and share common spatial patterns across subjects. Our method is built upon non-negative matrix decomposition techniques, enhanced by a data locality regularization term that makes the decomposition robust to imaging noise and improves spatial smoothness and functional coherences of the subject specific FNs. Our method also adopts automatic relevance determination techniques to eliminate redundant FNs in order to generate a compact set of informative sparse FNs. We have validated our method based on simulated, task fMRI, and resting state fMRI datasets. The experimental results have demonstrated our method could obtain subject specific, sparse, non-negative FNs with improved functional coherence, providing enhanced ability for characterizing the functional brain of individual subjects.

译文

:从静止状态的功能性MRI数据中划定大型功能网络(FNs)已成为探索神经科学中功能性大脑组织的标准工具。然而,现有方法牺牲了受试者特定的变异性,以维持组水平分析所必需的跨学科对应。为了获得在各个受试者之间可比较的特定于受试者的FN,现有的大脑分解技术通常采用启发式策略或对各个受试者的FN采取特定的统计分布,因此可能会产生偏差的结果。在这里,我们提出了一种新的数据驱动方法,用于在建立组级别对应关系时检测主题特定的FN。我们的方法同时为一组由组稀疏性正规化的主题计算特定主题FN,以生成空间稀疏且在各个主题之间共享公共空间模式的特定主题FN。我们的方法建立在非负矩阵分解技术的基础上,并通过数据局部性正则化术语进行了增强,该术语使分解对图像噪声具有鲁棒性,并提高了主题特定FN的空间平滑度和功能相干性。我们的方法还采用自动相关性确定技术来消除冗余FN,以便生成一组紧凑的信息稀疏FN。我们已经基于模拟,任务功能磁共振成像和静止状态功能磁共振成像数据集验证了我们的方法。实验结果表明,我们的方法可以获得具有改进的功能一致性的受试者特异性,稀疏,非阴性FN,从而增强了表征单个受试者的功能性大脑的能力。

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