Bisphenol A (BPA), 4-nonylphenol (4-NP) and 4-tert-octylphenol (4-tert-OP) are the endocrine disrupting chemicals (EDCs) that has been shown to exert both toxic and biological effects on living organisms. The present study investigated effects of environmentally relevant concentrations of BPA, 4-NP and 4-tert-OP (0.1, 1 and 10 mg/L) on the fecundity of fruit fly Drosophila melanogaster. In the all exposure groups of BPA, 4-NP and 4-tert-OP, it was found a statistically significant decrease in mean fecundity as compared to the control groups (p < 0.05).