The objective of this work was to characterize trends over time in urinary excretion of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among cigarette smokers in the US. We identified 35 studies presenting data that either reported, or could be converted to, common units of total urinary NNAL excretion as pmol/mg creatinine. The studies spanned 18years, reported urinary NNAL excretion estimates for 61 defined populations, and included a combined total of 3941 study participants. Analyses show that urinary NNAL excretion trends downward with study publication year, and the trend is statistically significant. The trend does not appear to be accounted for by a reduction in cigarettes smoked per day by study participants over the same time period. This trend is consistent with reductions in tobacco specific nitrosamine (TSNA) levels in both cigarette tobacco filler and mainstream cigarette smoke observed over the past decade and with efforts by the tobacco industry and the agricultural community to reduce levels of TSNAs in tobacco and cigarette smoke.

译文

:这项工作的目的是表征美国吸烟者中4-(甲基亚硝胺基)-1-(3-吡啶基)-1-丁醇(NNAL)随时间的排泄趋势。我们鉴定了35项研究,这些研究报告的数据报告或可以转换为总尿液NNAL排泄的常见单位为pmol / mg肌酐。这项研究历时18年,报告了61个特定人群的尿NNAL排泄量估计值,并且总共包括3941名研究参与者。分析显示,随着研究出版年份的增加,尿液NNAL排泄量呈下降趋势,并且该趋势具有统计学意义。研究参与者在同一时期内每天吸烟量的减少似乎不能解释这一趋势。这种趋势与在过去十年中观察到的卷烟烟草填充剂和主流卷烟烟雾中特定于烟草的亚硝胺(TSNA)水平的降低以及烟草业和农业界为降低烟草和卷烟烟雾中TSNA含量所做的努力是一致的。

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