Aim: To determine the prognostic value of Glasgow Prognostic Score (GPS) in acute exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) requiring hospitalization.Methods: Hospital electronic database of 129 patients with AECOPD was retrospectively searched and CRP levels, complete blood count, arterial blood gas (ABG) values and pulmonary function test (PFT) parameters of patients were recorded. Hospital mortality and need for ICU transfer were determined as adverse outcomes from files of cases.Results: 106 of 129 patients were male (82.2%) and rest of them were female (17.8%). GPS 0 was not observed in any patient, GPS 1 was observed in 101 patients, and GPS 2 was observed in 28 patients. The rate of adverse outcomes (ICU/Ex) was significantly increased in the GPS 2 group when compared to the GPS 1 group (X2:7.631, p < 0.01). Logistic regression analysis indicated that pH≤7.35 (p < 0.05, OR: 5.65, CI: 1.35-23.58%) and GPS 2 score (p < 0.05, OR: 5.52, CI: 1.45-20.97%) were independent predictors for adverse outcomes for AECOPD.Conclusion: Our results demonstrate that the GPS may have predictive value for adverse outcomes in patients with AECOPD.

译文

目的:确定格拉斯哥预后评分(GPS)在需要住院的慢性阻塞性肺疾病(AECOPD)急性加重中的预后价值。方法:回顾性搜索129例AECOPD患者的医院电子数据库,并检索CRP水平,全血细胞计数,记录患者的动脉血气(ABG)值和肺功能测试(PFT)参数。从病例档案中确定医院死亡率和需要ICU转移为不良结果。结果:129例患者中有106例为男性(82.2%),其余为女性(17.8%)。在任何患者中均未观察到GPS 0,在101位患者中观察到GPS 1,在28位患者中观察到GPS 2。与GPS 1组相比,GPS 2组的不良结局发生率(ICU / Ex)显着增加(X2:7.631,p <0.01)。 Logistic回归分析表明pH≤7.35(p <0.05,OR:5.65,CI:1.35-23.58%)和GPS 2评分(p <0.05,OR:5.52,CI:1.45-20.97%)是不良后果的独立预测因子结论:我们的结果表明,GPS可能对AECOPD患者的不良结局具有预测价值。

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