OBJECTIVE:In a recent study, we found that Greenlandic Inuit children had a more adverse metabolic profile than Danish children. Aerobic fitness and adiposity could only partly account for the differences. Therefore, we set out to evaluate and compare plasma leptin and adiponectin levels in Danish and Inuit children.
METHODS:In total, 187 Inuit and 132 Danish children (5.7-17.1 years) had examinations of anthropometrics, body fat content, pubertal staging, fasting blood and aerobic fitness.
RESULTS:Plasma leptin was higher in Danish boys [3,774 (4,741-3,005)] [pg/mL unadjusted geometric mean (95% CI)] compared to both northern [2,076 (2,525-1,706)] (p < 0.001) and southern (2,515 (3,137-2,016)) (p < 0.001) living Inuit boys and higher in Danish girls [6,988 (8,353-5,847)] compared to southern living Inuit girls [4,910 (6,370-3,785)] (p = 0.021) and tended to be higher compared to northern living Inuit girls [5,131 (6,444-4,085)] (p = 0.052). Plasma adiponectin was higher for both Danish boys [22,359 (2,573-19,428)] [ng/mL unadjusted geometric mean (95% CI)] and girls [26,609 (28,994-24,420)] compared to southern living Inuit boys [15,306 (18,406-12,728)] and girls [18,864 (22,640-15,717)] (both p < 0.001), respectively. All differences remained after adjustment for body fat percentage (BF%), aerobic fitness, age and puberty. The leptin/adiponectin ratio was higher in Danish boys and tended to be higher in Danish girls compared to northern living Inuit boys and girls, respectively. These differences were eliminated after adjustment for BF%, aerobic fitness, age and puberty.
CONCLUSIONS:In contrast to our hypothesis, plasma leptin was higher in Danish children despite a more healthy metabolic profile compared to Inuit children. As expected, plasma adiponectin was lowest in Inuit children with the most adverse metabolic profile.
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【Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children.].
【格陵兰因纽特人和丹麦儿童之间瘦素和脂联素水平的种族差异。】
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DOI：10.3402/ijch.v72i0.21458文章类型：杂志文章
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目的：在最近的一项研究中，我们发现格陵兰因纽特人儿童的代谢状况比丹麦儿童更严重。有氧健身和肥胖只能部分解释差异。因此，我们着手评估和比较丹麦和因纽特人儿童的血浆瘦素和脂联素水平。
方法：共有187名因纽特人和132名丹麦儿童（5.7-17.1岁）接受了人体测量学，体脂含量，青春期分期，空腹血液和有氧运动的检查。
结果：相比于北部地区[2,076（2,525-1,706）]（p <0.001）和南部地区（p <0.001），丹麦男孩血浆瘦素水平更高[pg / mL，未经调整的几何平均值（95％CI）]。 2,515（3,137-2,016））（p <0.001）在丹麦因纽特人中活着的男孩和更高[6,988（8,353-5,847）]，而在南部因纽特人中活着的女孩[4,910（6,370-3,785）]（p = 0.021），并且倾向于高于北部生活的因纽特人女孩[5,131（6,444-4,085）]（p = 0.052）。丹麦南部男孩[22,359（2,573-19,428）] [ng / mL未调整几何平均数（95％CI）]和女孩[26,609（28,994-24,420）]的血浆脂联素均高于南部因纽特人男孩[15,306（18,406- 12,728）和女孩[18,864（22,640-15,717）]（均p <0.001）。调整体脂百分比（BF％），有氧健身，年龄和青春期后，所有差异均保持不变。与北部生活的因纽特人男孩和女孩相比，丹麦男孩中的瘦素/脂联素比率更高，并且丹麦女孩中的瘦素/脂联素比率往往更高。在调整BF％，有氧适应性，年龄和青春期之后，消除了这些差异。
结论：与我们的假设相反，丹麦儿童的血浆瘦素水平高于因纽特人儿童，尽管其代谢状况更为健康。正如预期的那样，血浆脂联素在具有最不利代谢特征的因纽特人儿童中最低。
方法：共有187名因纽特人和132名丹麦儿童（5.7-17.1岁）接受了人体测量学，体脂含量，青春期分期，空腹血液和有氧运动的检查。
结果：相比于北部地区[2,076（2,525-1,706）]（p <0.001）和南部地区（p <0.001），丹麦男孩血浆瘦素水平更高[pg / mL，未经调整的几何平均值（95％CI）]。 2,515（3,137-2,016））（p <0.001）在丹麦因纽特人中活着的男孩和更高[6,988（8,353-5,847）]，而在南部因纽特人中活着的女孩[4,910（6,370-3,785）]（p = 0.021），并且倾向于高于北部生活的因纽特人女孩[5,131（6,444-4,085）]（p = 0.052）。丹麦南部男孩[22,359（2,573-19,428）] [ng / mL未调整几何平均数（95％CI）]和女孩[26,609（28,994-24,420）]的血浆脂联素均高于南部因纽特人男孩[15,306（18,406- 12,728）和女孩[18,864（22,640-15,717）]（均p <0.001）。调整体脂百分比（BF％），有氧健身，年龄和青春期后，所有差异均保持不变。与北部生活的因纽特人男孩和女孩相比，丹麦男孩中的瘦素/脂联素比率更高，并且丹麦女孩中的瘦素/脂联素比率往往更高。在调整BF％，有氧适应性，年龄和青春期之后，消除了这些差异。
结论：与我们的假设相反，丹麦儿童的血浆瘦素水平高于因纽特人儿童，尽管其代谢状况更为健康。正如预期的那样，血浆脂联素在具有最不利代谢特征的因纽特人儿童中最低。
