Many marine organisms attach to underwater surfaces using protein adhesives. These are basic proteins with high levels of the amino acid 3,4-dihydroxyphenylalanine and an extended flexible conformation. The hydroxylation of tyrosine residues plays a key role in the chemisorption of these polymers to surfaces and in the setting of the adhesive. These unique proteins are attracting biotechnological attention for application in industry and medicine. Recent development on the immobilization of antigens and antibodies, enzymes, cells and tissues, illustrate the great potential use of these adhesives for diagnostics and medicine. The use of these adhesive proteins as anticorrosive coats for metal also suggests important applications for industry.