OBJECTIVE:To assess and compare immediate effects of chest physiotherapy with positive expiratory pressure (PEP) versus oscillating PEP on transcutaneously measured blood-gas tensions in patients with cystic fibrosis.
METHODS:Fifteen patients (mean age 12.5 y, range 6.9-21.5 y) participated. The treatments were randomized and performed on 2 separate occasions, 8 weeks apart. Spirometry was conducted before and after each treatment. We transcutaneously measured oxygen tension (P(tO2).
RESULTS:There were no changes in spirometry values. During PEP, different trends in blood-gas tension were seen, and there were no consistent changes. During oscillating PEP, P(tO2) increased and P(tCO2) decreased. During oscillating PEP, P(tCO2) was lower and the intra-individual change in P(tCO2) was more pronounced than during PEP. The results obtained immediately after oscillating PEP showed a higher P(tO2) and a lower P(tCO2) than with PEP.
CONCLUSION:PEP and oscillating PEP can both cause transitory effects on blood gases in patients with cystic fibrosis. However, oscillating PEP alters blood-gas tensions more than does PEP, and hyperventilation during oscillating PEP may reduce treatment time.
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【Immediate changes in blood-gas tensions during chest physiotherapy with positive expiratory pressure and oscillating positive expiratory pressure in patients with cystic fibrosis.].
【患有肺囊性纤维化的患者，在呼气压力为正值且振荡的呼气压力为正值的情况下，进行胸部物理治疗时，血气压力立即变化。】
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目的：评估和比较采用呼气正压（PEP）和振荡PEP进行胸部物理治疗对囊性纤维化患者经皮测量的血气张力的即时效果。
方法：15例患者（平均年龄12.5岁，范围6.9-21.5岁）参加了研究。治疗是随机的，分别在两个不同的场合进行，相隔8周。在每次治疗之前和之后进行肺活量测定。我们经皮测量了氧气张力（P（tO2）。
结果：肺活量测定值没有变化。在PEP期间，观察到了血气紧张的不同趋势，并且没有一致的变化。在振荡PEP期间，P（tO2）增加而P（tCO2）减少。在振荡PEP期间，P（tCO2）较低，并且P（tCO2）的内部个体变化比PEP期间更为明显。振荡PEP后立即获得的结果显示，与PEP相比，P（tO2）更高，P（tCO2）更低。
结论：PEP和振荡PEP均可对囊性纤维化患者的血气产生短暂影响。但是，与PEP相比，振荡PEP对血气压力的改变更大，并且在振荡PEP期间过度换气可能会减少治疗时间。
方法：15例患者（平均年龄12.5岁，范围6.9-21.5岁）参加了研究。治疗是随机的，分别在两个不同的场合进行，相隔8周。在每次治疗之前和之后进行肺活量测定。我们经皮测量了氧气张力（P（tO2）。
结果：肺活量测定值没有变化。在PEP期间，观察到了血气紧张的不同趋势，并且没有一致的变化。在振荡PEP期间，P（tO2）增加而P（tCO2）减少。在振荡PEP期间，P（tCO2）较低，并且P（tCO2）的内部个体变化比PEP期间更为明显。振荡PEP后立即获得的结果显示，与PEP相比，P（tO2）更高，P（tCO2）更低。
结论：PEP和振荡PEP均可对囊性纤维化患者的血气产生短暂影响。但是，与PEP相比，振荡PEP对血气压力的改变更大，并且在振荡PEP期间过度换气可能会减少治疗时间。
