The use of herbal and natural remedies to prevent and manage disease is increasing in popularity. Individuals are attracted to the nonsynthetic qualities, affordability, and purity of natural remedies as compared to standard pharmacological and invasive interventions. Fish oil supplementation, for example, has been used in the management of dyslipidemia in patients choosing a natural approach to treatment or in adjunct to prescribed medication regimens. Research studies have supported the use of fish oil supplementation to reduce elevated levels of triglycerides and increase healthy cholesterol levels, as well as reduce the risk factors for cardiovascular disease. In this article, the use of fish oil supplementation to manage dyslipidemia will be explored, and considerations for this therapy for health care providers will be discussed.