BACKGROUND:Anorexia nervosa (AN) is a serious psychiatric illness associated with significant morbidity and mortality. Successful treatment results in weight restoration, but recidivism is common, and the rate of relapse is estimated to be as high as 50%. Maintenance of a healthy diet is central to the recovery process, but the relation between diet and relapse has not been investigated in AN patients. OBJECTIVE:The objective of the study was to determine whether diet energy density and diet variety in recently weight-restored women with AN predict outcome. DESIGN:After gaining weight to a body mass index (BMI; in kg/m(2)) of > or = 20, 47 hospitalized women completed 4-d food records, from which a mean diet energy density score (DEDS) and a mean diet variety score (DVS) were calculated. Outcome was determined at study end by using modified Morgan-Russell criteria, and it was dichotomized as "treatment success" or "treatment failure." Data were analyzed by using Student's t test. A logistic regression model was constructed to evaluate the effects of DEDS, DVS, and caloric intake on outcome. RESULTS:Groups did not differ significantly in mean measures of age, admission and weight-restored BMI, or caloric intake. However, DEDS and DVS were significantly higher in the success group than in the failure group. The success and failure groups were followed for a mean of 240 and 170 d, respectively. In the logistic regression model, DEDS (P = 0.016) and DVS (P = 0.048) but not caloric intake (P = 0.585) significantly predicted outcome. CONCLUSION:In recently weight-restored women with AN, lower DEDS and DVS but not caloric intake were associated with poor outcome.

译文

背景:神经性厌食症(AN)是一种严重的精神疾病,具有较高的发病率和死亡率。成功的治疗可以使体重恢复,但累犯是常见的,复发率估计高达50%。维持健康饮食对恢复过程至关重要,但尚未在AN患者中研究饮食与复发之间的关系。
目的:本研究的目的是确定近期体重减轻并患有AN的女性的饮食能量密度和饮食种类是否可以预测结果。
设计:体重增加到体重指数(BMI;以kg / m(2)表示)大于或等于20后,有47名住院妇女完成了4 d食物记录,从中得出平均饮食能量密度得分(DEDS)和计算平均饮食品种评分(DVS)。在研究结束时,使用改良的Morgan-Russell标准确定结果,并将结果分为“治疗成功”或“治疗失败”两类。数据使用学生t检验进行了分析。构建了逻辑回归模型以评估DEDS,DVS和热量摄入对结局的影响。
结果:各组在平均年龄,入院和体重减轻的BMI或热量摄入方面均无显着差异。但是,成功组的DEDS和DVS明显高于失败组。成功和失败组的平均随访时间分别为240和170 d。在逻辑回归模型中,DEDS(P = 0.016)和DVS(P = 0.048)而非热量摄入(P = 0.585)显着预测了结局。
结论:在最近体重减轻的AN患者中,较低的DEDS和DVS但热量摄入不高与预后不良有关。

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