BACKGROUND:Carnitine deficiency is common in patients on dialysis. Serum free carnitine concentration is significantly lower in patients on hemodialysis (HD) than in healthy individuals. However, there are few reports on serum free carnitine concentration in patients on peritoneal dialysis (PD).
METHODS:We examined serum concentrations of total, free, and acylcarnitine and the acylcarnitine/free carnitine ratio in 34 PD and 34 age-, sex-, and dialysis duration-matched HD patients. We investigated the prevalence of carnitine deficiency and clinical factors associated with carnitine deficiency in the PD group.
RESULTS:Prevalence of carnitine deficiency was 8.8% in the PD group and 17.7% in the HD group (p = 0.283). High risk of carnitine deficiency was found in 73.5% of the PD group and 76.4% of the HD group (p = 0.604). Carnitine insufficiency was found in 82.3% of the PD group and 88.2% of HD group (p = 0.733). Multivariate analysis revealed that duration of dialysis and age were independent predictors of serum free carnitine level in the PD group.
CONCLUSIONS:The prevalence of carnitine deficiency, high risk of carnitine deficiency, and carnitine insufficiency in PD patients was 8.8%, 73.5%, and 82.3%, respectively. These rates were comparable to those in patients on HD.
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【Prevalence of Carnitine Deficiency and Decreased Carnitine Levels in Patients on Peritoneal Dialysis.].
【腹膜透析患者的肉碱缺乏症患病率和肉碱水平降低。】
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DOI：10.3390/nu11112645文章类型：杂志文章
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背景：肉毒碱缺乏症在透析患者中很常见。血液透析（HD）患者的血清游离肉碱浓度明显低于健康个体。然而，很少有关于腹膜透析（PD）患者血清游离肉碱浓度的报道。
方法：我们检查了34名PD和34名年龄，性别和透析时间相匹配的HD患者的总，游离和酰基肉碱的血清浓度以及酰基肉碱/游离肉碱的比率。我们调查了PD组的肉碱缺乏症患病率以及与肉碱缺乏症相关的临床因素。
结果：PD组的肉碱缺乏症患病率为8.8％，HD组的肉碱缺乏症患病率为17.7％（p = 0.283）。 PD组的73.5％和HD组的76.4％发现了肉碱缺乏的高风险（p = 0.604）。 PD组有82.3％的人肉碱不足，HD组有88.2％的人肉碱不足（p = 0.733）。多因素分析显示，透析时间和年龄是PD组血清游离肉碱水平的独立预测因子。
结论：PD患者的肉碱缺乏症，肉碱缺乏症的高风险和肉碱不足的患病率分别为8.8％，73.5％和82.3％。这些比率与HD患者相当。
方法：我们检查了34名PD和34名年龄，性别和透析时间相匹配的HD患者的总，游离和酰基肉碱的血清浓度以及酰基肉碱/游离肉碱的比率。我们调查了PD组的肉碱缺乏症患病率以及与肉碱缺乏症相关的临床因素。
结果：PD组的肉碱缺乏症患病率为8.8％，HD组的肉碱缺乏症患病率为17.7％（p = 0.283）。 PD组的73.5％和HD组的76.4％发现了肉碱缺乏的高风险（p = 0.604）。 PD组有82.3％的人肉碱不足，HD组有88.2％的人肉碱不足（p = 0.733）。多因素分析显示，透析时间和年龄是PD组血清游离肉碱水平的独立预测因子。
结论：PD患者的肉碱缺乏症，肉碱缺乏症的高风险和肉碱不足的患病率分别为8.8％，73.5％和82.3％。这些比率与HD患者相当。
