Premotor respiratory neurons from neonatal rats express a Ba(2+)-insensitive outward rectifying K+ channel (KOR) which is activated by gamma-aminobutyric acid acting at its beta receptor. The biophysical properties of KOR are similar to those described for the S-channel (KS) which underlies simple forms of non-associative learning in the marine mollusc Aplysia. We show here that KOR, like the S-channel, is inhibited by cAMP. In addition, we demonstrate that this inhibition is due to a change in closed time kinetics. Our data suggests that the ionic and biochemical substrates underlying synaptic plasticity in Aplysia have been phylogenetically conserved in mammalian motor circuits such as that controlling rhythmic breathing movements.

译文

来自新生大鼠的运动前呼吸神经元表达Ba(2)不敏感的向外整流K通道(KOR),该通道被作用于其β受体的γ-氨基丁酸激活。 KOR的生物物理特性与描述于S通道(KS)的那些相似,后者是海洋软体动物海Ap中非缔合性学习的简单形式的基础。我们在这里显示,cAMP像S通道一样抑制KOR。此外,我们证明了这种抑制作用是由于封闭时间动力学的变化所致。我们的数据表明,海藻中突触可塑性的离子和生化底物在哺乳动物运动回路(如控制有节奏的呼吸运动)中在系统发育上是保守的。

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