Few well-constructed studies have systematically evaluated medical investigation protocols for children with autistic spectrum disorders. This is in large part due to the heterogeneous nature of the population and changing diagnostic frameworks. This review outlines the studies that have directed investigation strategies to date, and discusses how these might be applied in the clinical situation. The importance of listing the conditions that may be present on the basis of the specific clinical presentation, and using a thorough history and examination to generate a pre-test probability of the target disorders is emphasized if tests are to be useful in directing therapy or broader management approaches.

译文

:很少有结构完善的研究能够系统地评估自闭症谱系障碍儿童的医学研究方案。这在很大程度上是由于人群的异质性和不断变化的诊断框架。这篇综述概述了迄今为止指导研究策略的研究,并讨论了如何将这些策略应用于临床。如果测试对指导治疗或更广泛有用,则强调列出根据具体临床表现可能出现的疾病,并使用详尽的病史和检查以产生目标疾病的预测试概率的重要性。管理方法。

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