Differential killing of the patient's cancer cells versus normal cells is a necessity for chemotherapy. Advantage can be taken of close regulations of gene expression and of enzyme activity that are essential for normal cell functioning, and that are altered during tumor progression. Summarized here is our research on four such progression changes of cancer cells; some deregulate proliferation control and others decrease programmed death (apoptosis). These processes will be illustrated with examples of potential chemotherapies based on them. Methods for discovery of such changes include Differential Display and microarrays.

译文

对患者癌细胞与正常细胞的差异杀伤是化疗的必要条件。可以利用基因表达和酶活性的密切调节,这些调节对于正常细胞功能至关重要,并且在肿瘤进展过程中会发生改变。这里总结了我们对癌细胞四种此类进展变化的研究; 一些放松增殖控制,另一些减少程序性死亡 (凋亡)。这些过程将通过基于它们的潜在化学疗法的示例进行说明。发现这种变化的方法包括差分显示和微阵列。

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