As the coronavirus disease-2019 (COVID-19) pandemic continues, one major point of uncertainty is the impact this novel pathogen will have during the upcoming 2020 to 2021 flu season. While the influenza virus is a known contributor to human morbidity and mortality, the question of how a coinfection between COVID-19 and influenza might manifest is of utmost concern. The aim of this study was to review the limited cases of COVID-19/influenza coinfection currently available in the literature, along with cases in the community of El Paso, TX, to determine whether any patterns of clinical presentation and morbidity emerged. An international review of the literature was conducted. Six published articles describing COVID-19/influenza coinfection were identified, with a total of 13 patients described therein. Three additional patients were identified from the El Paso, TX data. The most common presenting symptoms were fever and cough. The most common laboratory findings were elevated C-reactive protein and lymphocytopenia. Thirteen patients presented with viral pneumonia findings on CT, and nine had findings of ground-glass opacity. Finally, complications were reported in six patients, with most common complication being acute respiratory distress syndrome. The results of the review indicate that, due to the similarity in presentation between COVID-19 and influenza, further analysis will be required to understand the effects of coinfection on morbidity and mortality. However, the limited number of coinfection cases in the literature indicates that the implementation of COVID-19 control measures may continue to play a role in limiting the spread of these human respiratory pathogens.

译文

随着冠状病毒病2019 (新型冠状病毒肺炎) 大流行的继续,一个主要的不确定性点是这种新型病原体在即将到来的2020 2021年流感季节将产生的影响。虽然流感病毒是人类发病率和死亡率的已知因素,新型冠状病毒肺炎和流感之间的共同感染如何表现的问题是最令人担忧的。这项研究的目的是回顾目前文献中有限新型冠状病毒肺炎/流感共感染病例,以及德克萨斯州埃尔帕索社区的病例,以确定是否出现任何临床表现和发病率模式。对文献进行了国际审查。确定了六篇描述新型冠状病毒肺炎/流感共感染的已发表文章,其中总共描述了13名患者。从德克萨斯州埃尔帕索的数据中发现了另外三名患者。最常见的症状是发热和咳嗽。最常见的实验室检查结果是C反应蛋白升高和淋巴细胞减少。13例患者在CT上表现为病毒性肺炎,9例出现毛玻璃混浊。最后,有6例患者报告了并发症,其中最常见的并发症是急性呼吸窘迫综合征。审查结果表明新型冠状病毒肺炎和流感在表现上的相似性,需要进一步分析以了解合并感染对发病率和死亡率的影响。然而,文献中合并感染病例的数量有限,这表明新型冠状病毒肺炎控制措施的实施可能继续在限制这些人类呼吸道病原体的传播方面发挥作用。

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