• 【IMA侧支栓塞治疗CABG后缺血。】 复制标题 收藏 收藏
    DOI:10.1016/s0003-4975(97)00434-7 复制DOI
    作者列表:Hartz RS,Heuser RR
    BACKGROUND & AIMS: :The existence of a chest wall "steal" of blood away from the myocardium through patent internal mammary artery branches has been hypothesized as a cause of recurrent angina pectoris after coronary artery bypass grafting. Although some authors believe that such a steal is physiologically impossible because coronary flow occurs in diastole and chest wall flow in systole, we recently documented ischemia in the left anterior descending coronary artery distribution before embolization of a large left internal mammary artery first intercostal branch that had been left intact at the time of operation. After embolization of the branch, clinical and objective evidence of ischemia resolved.
    背景与目标: 有人认为,通过冠状动脉旁路移植术,存在通过乳腺内动脉分支从心肌中“偷走”血液的胸壁现象,是导致心绞痛复发的原因。尽管一些作者认为,这种盗窃行为在生理上是不可能的,因为冠状动脉血流发生在舒张期,而胸壁血流发生在收缩期,但我们最近记录了左前降支冠状动脉局部缺血,然后栓塞了一个较大的左乳内动脉第一个肋间分支。在手术时保持完好无损。分支栓塞后,缺血的临床和客观证据得以解决。
  • 【超选择性血管造影栓塞治疗难治性鼻epi。】 复制标题 收藏 收藏
    DOI:10.1080/00016480701596070 复制DOI
    作者列表:Fukutsuji K,Nishiike S,Aihara T,Uno M,Harada T,Gyoten M,Imai S
    BACKGROUND & AIMS: CONCLUSIONS:Routine embolization of the ipsilateral facial artery (FA) is effective because of the high success rate. The use of different embolic materials for the internal maxillary artery (IMA) and the FA was considered safe because of the absence of major complications. OBJECTIVE:To evaluate outcomes of routine embolization of the FA as well as the IMA ipsilateral to the bleeding site for intractable epistaxis, and outcomes using different embolic materials for the FA and the IMA. PATIENTS AND METHODS:Twenty-two patients with intractable epistaxis who underwent superselective embolization were retrospectively analyzed with a mean follow-up of 7 months. The FA and the IMA ipsilateral to the bleeding site were embolized. Two embolic materials, gelatin sponge and microcoils, were used for the IMA and the FA, respectively. RESULTS:The short-term success rate within the first 7 days was 77.3% (17/22). The long-term success rate was 95.5% (21/22). There were no major complications in 22 cases. Minor complications occurred in 13 cases (59%). These minor complications usually did not last more than a week and most resolved within a day.
    背景与目标: 结论:同侧面部动脉的常规血栓栓塞术是成功的,因为它具有较高的成功率。由于没有重大并发症,因此上颌内动脉(IMA)和FA使用不同的栓塞材料被认为是安全的。
    目的:评估常规栓塞术以及出血部位同侧IMA的顽固性鼻栓的结局,以及对FA和IMA使用不同栓塞材料的结局。
    病人与方法:回顾性分析了22例行超选择性栓塞治疗的顽固性鼻patients患者,平均随访7个月。将与出血部位同侧的FA和IMA栓塞。两种栓塞材料分别是明胶海绵和微线圈,分别用于IMA和FA。
    结果:前7天内的短期成功率为77.3%(17/22)。长期成功率为95.5%(21/22)。 22例无重大并发症。轻微并发症发生13例(59%)。这些轻微的并发症通常不会持续超过一周,并且大多数会在一天之内解决。
  • 【使用经校准的tris-acryl明胶微球体对有或无子宫平滑肌瘤的有症状子宫腺肌病的子宫动脉栓塞术:中期临床和MR影像学随访。】 复制标题 收藏 收藏
    DOI:10.1016/j.jvir.2007.04.024 复制DOI
    作者列表:Lohle PN,De Vries J,Klazen CA,Boekkooi PF,Vervest HA,Smeets AJ,Lampmann LE,Kroencke TJ
    BACKGROUND & AIMS: PURPOSE:To evaluate clinical and magnetic resonance (MR) imaging results after uterine artery embolization (UAE) in women with symptomatic adenomyosis with or without uterine leiomyomas. MATERIALS AND METHODS:Thirty-eight women with symptomatic adenomyosis with or without uterine leiomyomas were treated with UAE with calibrated tris-acryl gelatin microspheres. Based on MR findings, women were categorized as having pure adenomyosis (group A; n = 15), adenomyosis dominance with fibroid tumors (group B; n = 14), or fibroid tumor dominance with adenomyosis (group C; n = 9). RESULTS:Heavy menstrual bleeding, pain, and bulk-related symptoms at last follow-up at a median of 16.5 months (range, 3-38 months) were compared with baseline symptoms. With follow-up MR imaging at a median of 12 months (range, 3-36 months), changes in uterine volume, leiomyoma volume, junctional zone thickness, and contrast enhancement of adenomyosis were assessed. After embolization, adenomyosis infarction could be depicted on contrast medium-enhanced MR in 44.1% of cases. Median reductions of uterine volume, fibroid tumor volume, and junctional zone thickness were 44.8%, 77.1%, and 23.9%, respectively. In group A, three patients needed additional surgery after UAE, in addition to two in group B and one in group C. In the remaining 32 patients, except for one patient in group C, all preexisting symptoms (eg, bleeding, pain, bulk-related symptoms) improved or resolved after UAE. Overall, 84.2% of women were satisfied with the results of UAE. CONCLUSION:In this study, midterm results (at a median of 16.5 months) showed that UAE in symptomatic adenomyosis with or without uterine leiomyomas is effective. Hysterectomy was avoided in the vast majority of patients. MR imaging showed reduction of uterine volume and junctional zone thickness.
    背景与目标: 目的:评估伴有或不伴子宫平滑肌瘤的有症状子宫腺肌病妇女子宫动脉栓塞(UAE)后的临床和磁共振(MR)成像结果。
    材料与方法:对38例有子宫腺肌瘤或无子宫肌瘤的有症状子宫腺肌病的妇女用经校准的tris-acryl明胶微球进行UAE治疗。根据MR结果,将女性分为纯腺肌病(A组; n = 15),腺肌病占纤维瘤的优势(B组; n = 14)或肌瘤伴腺肌病的优势(C组; n = 9)。
    结果:最后一次随访中月经大出血,疼痛和与大块相关的症状的中位数为16.5个月(范围3-38个月),与基线症状进行了比较。在中位12个月(范围3-36个月)内进行随访MR成像,评估子宫体积,平滑肌瘤体积,交界区厚度和子宫腺肌病造影剂增强情况的变化。栓塞后,在44.1%的病例中,造影剂增强型MR可以描绘出子宫腺肌梗塞。子宫体积,肌瘤体积和交界区厚度减少的中位数分别为44.8%,77.1%和23.9%。在A组中,除了B组中的两名和C组中的一名之外,三名患者需要在阿联酋手术后接受其他手术。在其余32名患者中,除了C组中的一名患者外,所有患者均已存在症状(例如,出血,疼痛,肿大相关症状)在阿联酋后得到改善或解决。总体而言,有84.2%的女性对阿联酋的成绩感到满意。
    结论:在这项研究中,中期结果(中位值为16.5个月)表明,阿联酋在有症状或无子宫平滑肌瘤的有症状子宫腺肌病中是有效的。绝大多数患者避免子宫切除术。磁共振成像显示子宫体积和交界区厚度减少。
  • 【Guglielmi可分离式线圈栓塞术对颈内动脉血泡样动脉瘤的一级治疗。】 复制标题 收藏 收藏
    DOI:10.1016/j.jocn.2007.08.023 复制DOI
    作者列表:Doorenbosch X,Harding M
    BACKGROUND & AIMS: :Blood-blister-like aneurysms (BBAs) are rare but challenging to treat owing to their fragile, thin walls and poorly defined necks. Studies have shown many complications related to this type of aneurysm. In particularly, other authors have reported high rates of complications arising within a few weeks of BBAs treated with primary endovascular coiling. We report a 44-year-old woman with subarachnoid haemorrhage due to a ruptured BBA to demonstrate successful primary treatment with endovascular coiling without complications or regrowth at 6-month follow up.
    背景与目标: :水疱样动脉瘤(BBA)很少见,但由于其脆弱,薄壁和颈部轮廓不清而难以治疗。研究表明,许多与此类型的动脉瘤有关的并发症。特别是,其他作者报告说,经原发性血管内盘绕治疗的BBA在几周内出现了很高的并发症发生率。我们报道了一名因BBA破裂而导致蛛网膜下腔出血的44岁女性,在6个月的随访中证明成功进行了血管内盘绕术且没有并发症或再生长的主要治疗方法。
  • 【膀胱癌:带有双表面线圈的MR成像。】 复制标题 收藏 收藏
    DOI:10.2214/ajr.151.1.107 复制DOI
    作者列表:Barentsz JO,Lemmens JA,Ruijs SH,Boskamp EB,Hendrikx AJ,Karthaus HF,Kaanders JH,Rosenbusch G
    BACKGROUND & AIMS: :Twenty-four patients with carcinoma of the urinary bladder were examined with MR imaging by using both a conventional body coil and a newly designed wraparound double surface coil. All patients had T1- and two patients had T2-weighted pulse sequences with both coils. Because of the long examination times, T2-weighted sequences in all other patients were obtained by using the double surface coil only. Nine patients underwent radical cystectomy, while the other patients had deep transurethral tumor resection and a clinical follow-up of at least 1.5 years. The results of imaging with the surface coil showed a twofold improvement of spatial resolution compared with the images obtained with the body coil. The RF field homogeneity was excellent, and the field of view was sufficiently large to achieve a complete study of the pelvis and the lower abdomen in one sequence. For the T1-weighted images, the higher spatial resolution of the double surface coil resulted in a significant (p less than .10) improvement in tumor staging. The accuracies of double-surface-coil and body-coil imaging were 79% and 54%, respectively. Double-surface-coil imaging appears to provide better MR images of the urinary bladder than body-coil imaging does, resulting in more accurate staging of tumors on T1-weighted pulse sequences.
    背景与目标: :使用常规体线圈和新设计的环绕式双面线圈对24例膀胱癌患者进行了MR成像检查。所有患者均具有T1,两个患者均具有两个线圈的T2加权脉冲序列。由于检查时间长,仅使用双面线圈即可获得所有其他患者的T2加权序列。 9例患者接受了根治性膀胱切除术,而其他患者进行了深经尿道肿瘤切除术并进行了至少1.5年的临床随访。与使用体线圈获得的图像相比,使用表面线圈成像的结果显示出空间分辨率提高了两倍。 RF场均匀性非常好,并且视野足够大,可以按一个顺序完整地研究骨盆和小腹。对于T1加权图像,双面线圈的较高空间分辨率导致了肿瘤分期的显着改善(p小于.10)。双面线圈和人体线圈成像的准确性分别为79%和54%。双线圈表面成像似乎比体线圈成像提供了更好的膀胱MR图像,从而在T1加权脉冲序列上实现了更准确的肿瘤分期。
  • 【原发性肿瘤的位置是大肠肝转移正接受门静脉栓塞作为大肝手术准备的大肠肝转移患者肝内无进展生存的预后因素。】 复制标题 收藏 收藏
    DOI:10.3390/cancers12061638 复制DOI
    作者列表:Hitpass L,Heise D,Schulze-Hagen M,Pedersoli F,Ulmer F,Amygdalos I,Isfort P,Neumann U,Kuhl C,Bruners P,Zimmermann M
    BACKGROUND & AIMS: :The aim of this study was to identify prognostic factors affecting intrahepatic progression-free survival (ihPFS) and overall survival (OS) in patients with colorectal cancer liver metastases (CRCLM) undergoing portal vein embolization (PVE) and subsequent (extended) right hemihepatectomy. A total of 59 patients (mean age: 60.8 ± 9.3 years) with CRCLM who underwent PVE in preparation for right hemihepatectomy were included. IhPFS and OS after PVE were calculated using the Kaplan-Meier method. Cox regression analyses were conducted to investigate the association between the following factors and survival: patient age, laterality of the colorectal cancer (right- versus left-sided), tumor location (colon versus rectal cancer), time of occurrence of hepatic metastases (synchronous versus metachronous), baseline number and size of hepatic metastases, presence or absence of metastases in the future liver remnant (FLR) before PVE, preoperative carcinoembryogenic antigen (CEA) levels, time between PVE and surgery, history of neoadjuvant or adjuvant chemotherapy, and the presence or absence of extrahepatic disease before PVE. Median follow up was 18 months. The median ihPFS was 8.2 months (95% confidence interval: 6.2-10.2 months), and median OS was 34.1 months (95% confidence interval: 27.3-40.9 months). Laterality of the primary colorectal cancer was the only statistically significant predictor of ihPFS after PVE (hazard ratio (HR) = 2.242; 95% confidence interval: 1.125, 4.465; p = 0.022), with patients with right-sided colorectal cancer having significantly shorter median ihPFS than patients with left-sided cancer (4.0 ± 1.9 months versus 10.2 ± 1.5 months; log rank test: p = 0.018). Other factors, in particular also the presence or absence of additional metastases in the FLR, were not associated with intrahepatic progression-free survival. The presence of extrahepatic disease was associated with worse OS (HR = 3.050, 95% confidence interval: 1.247, 7.459; p = 0.015).
    背景与目标: :这项研究的目的是确定影响大肠癌肝转移(CRCLM)接受门静脉栓塞(PVE)和随后的(扩展)右半肝切除术的患者的肝内无进展生存期(ihPFS)和总体生存期(OS)的预后因素。纳入总共59例CRCLM患者(平均年龄:60.8±9.3岁),他们接受了PVE准备右半肝切除术。使用Kaplan-Meier方法计算PVE后的IhPFS和OS。进行了Cox回归分析以调查以下因素与生存之间的关系:患者年龄,结直肠癌的偏侧性(右侧与左侧),肿瘤位置(结肠与直肠癌),肝转移发生的时间(同步)与异时),肝转移的基线数目和大小,PVE之前的未来肝残余(FLR)是否存在转移,术前致癌性胚抗原(CEA)水平,PVE与手术之间的时间,新辅助或辅助化疗的历史以及PVE之前是否存在肝外疾病。中位随访时间为18个月。 ihPFS的中位数为8.2个月(95%的置信区间:6.2-10.2个月),OS的中位数为34.1个月(95%的置信区间:27.3-40.9个月)。原发性结直肠癌的横向性是PVE后ihPFS的唯一统计学上显着的预测指标(危险比(HR)= 2.242; 95%的置信区间:1.125,4.465; p = 0.022),右侧结直肠癌患者的病程明显短ihPFS的中位数高于左侧癌症患者(4.0±1.9个月对10.2±1.5个月;对数秩检验:p = 0.018)。其他因素,特别是FLR中是否存在其他转移与肝内无进展生存期无关。肝外疾病的存在与OS恶化有关(HR = 3.050,95%置信区间:1.247,7.459; p = 0.015)。
  • 【第一空肠动脉无症状动脉栓塞。】 复制标题 收藏 收藏
    影响因子 :
    发表时间:2006-08-01
    来源期刊:Vasa
    DOI:10.1024/0301-1526.35.3.198 复制DOI
    作者列表:Shimohira M,Ogino H,Kitase M,Takeuchi M,Shibamoto Y
    BACKGROUND & AIMS: :In a 71-year-old man with a history of coronary artery bypassing using the left internal thoracic and gastroepiploic arteries, the first jejunal artery aneurysms were found by chance at 3D-CT performed to evaluate conditions of the grafts. He was successfully treated by transcatheter embolization using interlocking detachable coils. During a follow-up period of 5 months, the patient did well and had no sign of intestinal ischemia.
    背景与目标: :在一位71岁的男子中,他有使用左胸内和胃上动脉绕过冠状动脉的病史,在进行3D-CT评估移植状况时偶然发现了首例空肠动脉瘤。通过使用互锁的可拆卸线圈经导管栓塞术成功治疗了他。在5个月的随访期内,患者表现良好,没有肠道缺血的迹象。
  • 【支架时代黎明时进行的未破裂颅内动脉瘤的线圈栓塞术:日本神经内血管疗法注册中心(JR-NET)的结果3。】 复制标题 收藏 收藏
    DOI:10.2176/nmc.st.2019-0210 复制DOI
    作者列表:Satow T,Ikeda G,Takahashi JC,Iihara K,Sakai N,Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators.
    BACKGROUND & AIMS: :Endosaccular coiling is recognized as a feasible method for treating unruptured intracranial aneurysms (UIAs). We retrospectively reviewed cases of UIAs treated by coiling in the Japanese Registry of Neuroendovascular Therapy (JR-NET) 3, a nationwide survey of NET between 2010 and 2014, the beginning period of intracranial stents in Japan. Data were extracted for 6844 UIAs (6619 procedures) from 40,169 registered records of all NETs in the JR-NET 3 databases. The features of the aneurysms and procedures, immediate radiographic findings, procedure-related complications, and clinical outcomes at 30 days after the procedures were assessed. Of 6844 UIAs, 81.8% were located in the anterior circulation. The mean patient age was 61.3 years (72.4% females). Compared with the preceding JR-NET 1 and 2, there were significant increases (P <0.05) in the rates of the following in JR-NET 3: wide-necked and small UIAs measuring <10 mm (from 56.4% to 58.8%), adjunctive techniques (54.8% to 71.8%), and stent usage (1.1% to 22.1%). Both pre- (85.6% to 96.7%) and post-procedural (84.0% to 94.6%) antiplatelet therapy were more frequently administered in JR-NET 3. Although procedure-related complication rates did not differ between the two groups, ischemic complication rates increased from 4.6% to 5.9%, leading to an increase in the 30-day morbidity (modified Rankin Scale >2) from 2.1% to 2.8%. In conclusion, introduction of neck-bridge stent was associated with an increase in cases of wide-necked aneurysms. However, the ischemic complication rate increased despite the greater use of periprocedural antiplatelet therapy.
    背景与目标: :囊状内盘绕术被认为是治疗未破裂颅内动脉瘤(UIA)的可行方法。我们回顾性研究了日本神经内膜血管治疗注册中心(JR-NET)3中盘绕治疗的UIA病例,JR-NET是2010年至2014年(日本颅内支架起始时期)的全国性NET调查。从JR-NET 3数据库中所有NET的40,169个注册记录中提取了6844个UIA(6619个过程)的数据。评估术后30天的动脉瘤和手术的特征,即时影像学发现,与手术相关的并发症以及临床结局。在6844个UIA中,有81.8%位于前循环中。患者平均年龄为61.3岁(女性为72.4%)。与先前的JR-NET 1和2相比,JR-NET 3中的下列比率显着增加(P <0.05):颈宽小于10 mm的小UIA(从56.4%增至58.8%) ,辅助技术(54.8%至71.8%)和支架使用率(1.1%至22.1%)。在JR-NET 3中,抗血小板治疗前(85.6%至96.7%)和术后(84.0%至94.6%)抗血小板治疗均更频繁。尽管两组的手术相关并发症发生率无差异,但缺血性并发症发生率从4.6%增加到5.9%,导致30天发病率(Rankin量表修正为> 2)从2.1%增加到2.8%。总之,颈桥支架的引入与宽颈动脉瘤病例的增加有关。然而,尽管更多地使用了围手术期抗血小板治疗,但缺血性并发症的发生率却有所增加。
  • 【用三丙烯酸明胶微球栓塞胰腺胰岛素瘤作为确定的治疗方法。】 复制标题 收藏 收藏
    DOI:10.1007/s00270-007-9185-4 复制DOI
    作者列表:Rott G,Biggemann M,Pfohl M
    BACKGROUND & AIMS: :Insulinomas are rare, mostly benign neuroendocrine tumors, originating in 99% of cases from the pancreas, that synthesize and secrete insulin, causing symptomatic hypoglycemia. Today the treatment of choice is surgical removal. We present the case of an 84-year-old woman with a symptomatic insulinoma who refused surgery and was treated with arterial embolization using trisacryl gelatin microspheres as definitive treatment.
    背景与目标: :胰岛素瘤是罕见的,主要是良性神经内分泌肿瘤,起源于99%的胰腺,是由胰岛素合成和分泌的,引起症状性低血糖。今天,选择的治疗方法是手术切除。我们介绍了一个有症状的胰岛素瘤的84岁妇女的病例,该妇女拒绝手术并且接受了使用三丙烯酸酯明胶微球作为确定性治疗的动脉栓塞治疗。
  • 【MORC2通过其C末端卷曲螺旋结构域的二聚化可增强染色质动力学并促进DNA修复。】 复制标题 收藏 收藏
    DOI:10.1186/s12964-019-0477-5 复制DOI
    作者列表:Xie HY,Zhang TM,Hu SY,Shao ZM,Li DQ
    BACKGROUND & AIMS: :Decondesation of the highly compacted chromatin architecture is essential for efficient DNA repair, but how this is achieved remains largely unknown. Here, we report that microrchidia family CW-type zinc finger protein 2 (MORC2), a newly identified ATPase-dependent chromatin remodeling enzyme, is required for nucleosome destabilization after DNA damage through loosening the histone-DNA interaction. Depletion of MORC2 attenuates phosphorylated histone H2AX (γH2AX) focal formation, compromises the recruitment of DNA repair proteins, BRCA1, 53BP1, and Rad51, to sites of DNA damage, and consequently reduces cell survival following treatment with DNA-damaging chemotherapeutic drug camptothecin (CPT). Furthermore, we demonstrate that MORC2 can form a homodimer through its C-terminal coiled-coil (CC) domain, a process that is enhanced in response to CPT-induced DNA damage. Deletion of the C-terminal CC domain in MORC2 disrupts its homodimer formation and impairs its ability to destabilize histone-DNA interaction after DNA damage. Consistently, expression of dimerization-defective MORC2 mutant results in impaired the recruitment of DNA repair proteins to damaged chromatin and decreased cell survival after CPT treatment. Together, these findings uncover a new mechanism for MORC2 in modulating chromatin dynamics and DDR signaling through its c-terminal dimerization.
    背景与目标: :高度紧凑的染色质结构的去污对于有效的DNA修复是必不可少的,但是如何实现这一点仍然未知。在这里,我们报告微裂口虫家族CW型锌指蛋白2(MORC2),一种新鉴定的ATPase依赖的染色质重塑酶,是DNA损伤后通过松散组蛋白-DNA相互作用造成核小体失稳所必需的。 MORC2的耗尽会减弱磷酸化的组蛋白H2AX(γH2AX)的病灶形成,损害DNA修复蛋白,BRCA1、53BP1和Rad51募集到DNA损伤的部位,并因此在用破坏性DNA的治疗药物喜树碱(CPT)处理后降低细胞存活率)。此外,我们证明MORC2可以通过其C末端卷曲螺旋(CC)结构域形成同型二聚体,这一过程在响应CPT诱导的DNA损伤时得到了增强。 DNA损伤后,MORC2中C末端CC结构域的缺失会破坏其同二聚体的形成,并削弱其破坏组蛋白与DNA相互作用的能力。一致地,二聚化缺陷的MORC2突变体的表达导致DNA修复蛋白募集到受损的染色质上受损,并降低了CPT处理后的细胞存活率。这些发现共同揭示了MORC2通过其c端二聚化调节染色质动力学和DDR信号传导的新机制。
  • 【肾VX-2癌的经导管动脉栓塞:埃塞多多-乙醇毛细管栓塞联合卡铂。】 复制标题 收藏 收藏
    DOI:10.3348/kjr.2007.8.2.136 复制DOI
    作者列表:Kónya A,Choi BG,Van Pelt CS,Wright KC
    BACKGROUND & AIMS: OBJECTIVE:We wanted to determine whether transcatheter Ethiodol-based capillary embolization in combination with carboplatin could improve the efficiency of a 1:1 Ethiodol-ethanol mixture (EEM) to ablate kidneys that been inoculated with VX-2 carcinoma. MATERIALS AND METHODS:The right kidney in 34 New Zealand white rabbits were inoculated with fresh VX-2 tumor fragments. One week later, the kidneys were subjected to transarterial treatment (4-5 rabbits/group): Saline infusion (Group 1); carboplatin infusion (5 or 10 mg, Groups 2A and 2B); carboplatin-Ethiodol (CE) alone (Group 3) and followed by main renal artery occlusion with ethanol (RAO) (Group 4); carboplatin-EEM (C-EEM) followed by RAO (Group 5); carboplatin infusion followed by EEM plus RAO (Group 6); and EEM followed by RAO (Group 7). The animals were followed for up to 3-weeks. The treated kidneys were evaluated angiographically and macroscopically. The kidneys that showed successful embolization macroscopically were entirely cut into serial sections, and these were examined microscopically. Histologically, the kidneys were evaluated on the basis of the residual tumor found in the serial sections. RESULTS:The results obtained with carboplatin infusion alone (Groups 2A and 2B) and CE without RAO (Group 3) were similar to those of the control animals (Group 1). Kidneys from Groups 4-7 demonstrated macroscopically successful embolization with histologically proven complete renal parenchyma infarction; however, some residual tumor was evident in all but one animal. CONCLUSION:None of the Ethiodol-based modalities combined with locoregional carboplatin were more efficacious for tumor ablation than EEM alone.
    背景与目标: 目的:我们想确定基于导管的基于埃塞俄多的毛细管栓塞术与卡铂联合使用是否可以提高1:1埃塞俄多-乙醇混合物(EEM)消融接种了VX-2癌的肾脏的效率。
    材料与方法:在34只新西兰白兔的右肾中接种新鲜的VX-2肿瘤片段。一周后,对肾脏进行经动脉治疗(每组4-5只兔子):盐水注入(第1组);盐水注入(第1组)。卡铂输注(5或10毫克,第2A和2B组);单独使用卡铂-埃塞多(CE)(第3组),然后用乙醇(RAO)阻塞主肾动脉(第4组);卡铂-EEM(C-EEM),然后是RAO(第5组);卡铂输注,然后进行EEM加RAO(第6组);和EEM,然后是RAO(第7组)。跟踪动物长达3周。通过血管造影和肉眼评估治疗的肾脏。在宏观上显示出成功栓塞的肾脏被完全切成连续切片,并在显微镜下进行检查。组织学上,根据在连续切片中发现的残留肿瘤评估肾脏。
    结果:单独使用卡铂(2A和2B组)和不使用RAO的CE(第3组)获得的结果与对照动物(第1组)相似。来自第4-7组的肾脏在宏观上证明栓塞成功,并在组织学上证明完全肾实质梗死。然而,除了一只动物以外,在所有动物中都可见一些残留的肿瘤。
    结论:以Ethiodol为基础的治疗方法与局部卡铂联合治疗均比单独的EEM更有效。
  • 【肺动静脉畸形栓塞后使用可拆卸的硅胶球囊进行长期随访。】 复制标题 收藏 收藏
    DOI:10.1007/s00270-007-9256-6 复制DOI
    作者列表:Andersen PE,Kjeldsen AD
    BACKGROUND & AIMS: :Long-term follow-up results after embolization of 13 pulmonary arteriovenous malformations in 10 patients by use of 14 detachable silicone balloons are given. Patients were followed for a mean of 99 months (range, 63-123 months) with chest x-rays and for a mean of 62 months (range, 3-101 months) with pulmonary angiography. Fifty-four percent of the balloons were deflated at latest radiographic chest film follow-up, but at pulmonary angiographic follow-up all embolized malformations were without flow irrespective of whether or not the balloons were visible. Detachable silicone balloons are not available anymore, but use of these balloons for embolization of pulmonary arteriovenous malformations has been shown to be a safe and precise method, with immediate occlusion of the feeding artery and with long-lasting occlusion, even though many balloons deflate with time, leaving a fibrotic scar replacing the pulmonary arteriovenous malformation. No case of recanalization has been discovered, and these results seem to justify a reduced number of controls of these balloon-embolized malformations.
    背景与目标: :通过使用14个可拆卸硅胶球囊对10例患者的13种肺动静脉畸形栓塞后的长期随访结果。对患者进行了平均99个月(63-123个月)的胸部X光检查,对平均62个月(3-101个月)的肺动脉造影进行了随访。在最新的X线胸片随访中,有54%的气球放气,但在肺部血管造影随访中,无论是否可见气球,所有栓塞畸形均无血流。可拆卸的硅胶球囊已不再可用,但已证明将这些球囊用于肺动静脉畸形的栓塞术是一种安全,精确的方法,即使许多球囊会随着时间的推移而feeding缩进食动脉,也可长期闭塞。时间,留下的纤维化疤痕替代了肺动静脉畸形。没有发现再通的病例,这些结果似乎证明减少了这些球囊栓塞畸形对照的数量。
  • 【1.5T轨道的表面线圈磁共振成像。】 复制标题 收藏 收藏
    影响因子 :
    发表时间:1988-11-01
    来源期刊:Rofo
    DOI:10.1055/s-2008-1048391 复制DOI
    作者列表:Wilms G,Marchal G,Decrop E,van Hecke P,Baert A,Dralands G
    BACKGROUND & AIMS: :MRI of the orbit at 1.5-Tesla was performed in 5 healthy volunteers and 30 patients with a variety of pathological intraocular or intraconal conditions. Major advantages of MRI over CT include higher spatial resolution, higher tissue contrast, possibility of direct multiplanar imaging, absence of bony and dental artifacts, and of ionising radiation. Specific indications of MRI in orbital pathology concern differentiation of uveal melanoma from subretinal haemorrhage, identification of lesions of the orbital apex, the orbital fissure or the optic canal, differentiation of inflammatory pseudotumour from malignant lesions, determination of the posterior extension of lesions of the optic nerve, and detection of abnormal flow in normal or hypertrophic intraorbital vessels. Limitations are due to motion artifacts on T2 weighted sequences, less accurate visualisation of calcification, poor specificity of some findings, and absence of signal from cortical bone.
    背景与目标: :在5名健康志愿者和30名患有各种病理性眼内或圆锥内疾病的患者中进行了1.5-Tesla眼眶的MRI检查。 MRI优于CT的主要优点包括更高的空间分辨率,更高的组织对比度,直接多平面成像的可能性,无骨和牙齿伪影以及电离辐射。眼眶病变的MRI特定指征涉及葡萄膜黑色素瘤与视网膜下出血的区别,眼眶顶点,眼眶裂孔或视神经管的病变的识别,炎性假瘤与恶性病变的区别,对视神经病变的向后扩展的确定神经,以及正常或肥大的眶内血管中异常血流的检测。局限性是由于T2加权序列上的运动伪影,钙化的可视化效果较差,某些发现的特异性差以及皮质骨信号缺失所致。
  • 【栓塞材料在动静脉畸形的立体定向放射外科手术剂量计算中的作用。】 复制标题 收藏 收藏
    DOI:10.1016/j.meddos.2012.07.009 复制DOI
    作者列表:Galván de la Cruz OO,Lárraga-Gutiérrez JM,Moreno-Jiménez S,García-Garduño OA,Celis MA
    BACKGROUND & AIMS: :It is reported in the literature that the material used in an embolization of an arteriovenous malformation (AVM) can attenuate the radiation beams used in stereotactic radiosurgery (SRS) up to 10% to 15%. The purpose of this work is to assess the dosimetric impact of this attenuating material in the SRS treatment of embolized AVMs, using Monte Carlo simulations assuming clinical conditions. A commercial Monte Carlo dose calculation engine was used to recalculate the dose distribution of 20 AVMs previously planned with a pencil beam dose calculation algorithm. Dose distributions were compared using the following metrics: average, minimal and maximum dose of AVM, and 2D gamma index. The effect in the obliteration rate was investigated using radiobiological models. It was found that the dosimetric impact of the embolization material is less than 1.0 Gy in the prescription dose to the AVM for the 20 cases studied. The impact in the obliteration rate is less than 4.0%. There is reported evidence in the literature that embolized AVMs treated with SRS have low obliteration rates. This work shows that there are dosimetric implications that should be considered in the final treatment decisions for embolized AVMs.
    背景与目标: :据文献报道,用于动静脉畸形(AVM)栓塞的材料可使立体定向放射外科(SRS)中使用的辐射束衰减多达10%至15%。这项工作的目的是在假定临床条件的情况下,使用蒙特卡罗模拟评估该衰减材料在栓塞性AVM的SRS治疗中的剂量学影响。商业的蒙特卡洛剂量计算引擎用于重新计算以前用笔形束剂量计算算法计划的20个AVM的剂量分布。使用以下指标比较了剂量分布:AVM的平均,最小和最大剂量,以及2D伽玛指数。使用放射生物学模型研究了闭塞率的影响。发现在研究的20例病例中,栓塞材料对AVM的处方剂量对剂量的影响小于1.0 Gy。闭塞率的影响小于4.0%。文献中有证据表明,经SRS治疗的栓塞性AVM闭塞率低。这项工作表明在栓塞性AVM的最终治疗决策中应考虑剂量学意义。
  • 【人工卷曲螺旋蛋白单层的力调制电导。】 复制标题 收藏 收藏
    DOI:10.1002/bip.22181 复制DOI
    作者列表:Atanassov A,Hendler Z,Berkovich I,Ashkenasy G,Ashkenasy N
    BACKGROUND & AIMS: :Studies of charge transport through proteins bridged between two electrodes have been the subject of intense research in recent years. However, the complex structure of proteins makes it difficult to elucidate transport mechanisms, and the use of simple peptide oligomers may be an over simplified model of the proteins. To bridge this structural gap, we present here studies of charge transport through artificial parallel coiled-coil proteins conducted in dry environment. Protein monolayers uniaxially oriented at an angle of ∼ 30° with respect to the surface normal were prepared. Current voltage measurements, obtained using conductive-probe atomic force microscopy, revealed the mechano-electronic behavior of the protein films. It was found that the low voltage conductance of the protein monolayer increases linearly with applied force, mainly due to increase in the tip contact area. Negligible compression of the films for loads below 26 nN allowed estimating a tunneling attenuation factor, β(0) , of 0.5-0.6 Å(-1) , which is akin to charge transfer by tunneling mechanism, despite the comparably large charge transport distance. These studies show that mechano-electronic behavior of proteins can shed light on their complex charge transport mechanisms, and on how these mechanisms depend on the detailed structure of the proteins. Such studies may provide insightful information on charge transfer in biological systems.
    背景与目标: 近年来,通过跨两个电极的蛋白质进行电荷传输的研究一直是研究的重点。但是,蛋白质的复杂结构使得难以阐明转运机制,并且简单肽寡聚物的使用可能是蛋白质的过度简化模型。为了弥合这种结构缺口,我们在这里介绍了在干燥环境中通过人工平行卷曲螺旋蛋白进行电荷传输的研究。制备相对于表面法线单轴取向约30°的蛋白质单分子层。使用导电探针原子力显微镜获得的当前电压测量结果揭示了蛋白质膜的机械电子行为。已经发现,蛋白质单层的低电导率随着施加的力线性增加,这主要是由于尖端接触面积的增加。对于低于26 nN的负载,薄膜的压缩可忽略不计,因此可以估算出隧穿衰减因子β(0)为0.5-0.6Å(-1),尽管电荷传输距离相对较大,但类似于通过隧穿机制进行的电荷转移。这些研究表明,蛋白质的机电行为可以阐明其复杂的电荷传输机制,以及这些机制如何依赖于蛋白质的详细结构。这样的研究可以提供有关生物系统中电荷转移的有见地的信息。

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