Klebsiella pneumoniae carbapenemase (KPC)-type enzymes have largely disseminated worldwide among K. pneumoniae isolates. In this study, 11 non-K. pneumoniae KPC-producing enterobacterial isolates from four hospitals located in different Colombian cities were genetically investigated. All isolates were multidrug-resistant and harboured the bla(KPC-2) gene along with several other acquired β-lactamase genes. The bla(KPC-2) gene was associated with transposon Tn4401b inserted in different loci of plasmids varying in size and replicon type. The presence of KPC-2 in different enterobacterial species from different cities within Colombia underlines the spread of KPC beyond K. pneumoniae.

译文

肺炎克雷伯菌碳青霉烯酶 (KPC) 型酶已在全球范围内广泛传播。肺炎克雷伯菌分离株。在这项研究中,对来自哥伦比亚不同城市的四家医院的11种非肺炎克雷伯菌产肠杆菌分离株进行了基因研究。所有分离株均具有多药耐药性,并带有bla(KPC-2) 基因以及其他几种获得的 β-内酰胺酶基因。bla(KPC-2) 基因与转座子Tn4401b相关,转座子Tn4401b插入不同大小和复制子类型的质粒的不同位点。来自哥伦比亚不同城市的不同肠杆菌物种中存在KPC-2,这突显了KPC在肺炎克雷伯菌以外的传播。

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