Hydrogel polymers have many applications in regenerative medicine. The aim of this study in dogs was to investigate bone regeneration in dehiscence-type peri-implant defects created surgically and treated with (i) biphasic calcium phosphate (BCP) granules alone; (ii) a composite putty hydroxypropyl methylcellulose (HPMC)/BCP (MBCP/putty); and (iii) a polymer crosslinked membrane of silanized-HPMC (Si-HPMC/BCP) compared with empty controls. At 3 months, new bone formation was significantly more important in defects filled with HPMC/BCP or Si-HPMC/BCP compared with spontaneous healing in control (P = 0.032 and P = 0.046 respectively) and more substantial compared with BCP alone. Furthermore, new bone formation in direct contact with the implant surface was observed in all three groups treated with BCP. The addition of HPMC to the BCP granules may have enhanced the initial stability of the material within the blood clot in these large and complex osseous defects. The Si-HPMC hydrogel may also act as an occlusive membrane covering the BCP, which could improve the stability of the granules in the defect area. However, the crosslinking time of the Si-HPMC is too long for easy handling and the mechanical properties remain to be improved. The composite MBCP/putty appears to be a valuable bone-graft material in complex defects in periodontology and implantology. These encouraging results should now be confirmed in clinical studies.

译文

水凝胶聚合物在再生医学中有许多应用。这项研究的目的是在狗中研究通过手术产生并仅用双相磷酸钙 (BCP) 颗粒治疗的开裂型种植体周围缺损的骨再生; (ii) 复合腻子羟丙基甲基纤维素 (HPMC)/BCP (MBCP/putty); (iii) 与空对照相比,硅烷化-HPMC (Si-HPMC/BCP) 的聚合物交联膜。在3个月时,与对照组的自发愈合相比,新骨形成在HPMC/BCP或Si-HPMC/BCP填充的缺损中明显更重要 (分别为P = 0.032和P = 0.046),并且与单独的BCP相比更重要。此外,在接受BCP治疗的所有三组中,均观察到与植入物表面直接接触的新骨形成。在BCP颗粒中添加HPMC可能会增强这些大而复杂的骨缺损中血凝块内材料的初始稳定性。Si-HPMC水凝胶也可以充当覆盖BCP的闭塞膜,这可以改善缺陷区域中颗粒的稳定性。然而,Si-HPMC的交联时间太长,无法轻松处理,并且机械性能仍有待改善。在牙周病学和种植学的复杂缺陷中,复合MBCP/腻子似乎是一种有价值的骨移植材料。这些令人鼓舞的结果现在应该在临床研究中得到证实。

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