• 【壳聚糖-磷酸甘油/血液植入物增加钻孔软骨缺损中的细胞募集,瞬时血管化和软骨下骨重塑。】 复制标题 收藏 收藏
    DOI:10.1016/j.joca.2006.08.007 复制DOI
    作者列表:Chevrier A,Hoemann CD,Sun J,Buschmann MD
    BACKGROUND & AIMS: OBJECTIVE:Marrow-stimulation techniques are used by surgeons to repair cartilage lesions although consistent regeneration of hyaline cartilage is rare. We have shown previously that autologous blood can be mixed with a polymer solution containing chitosan in a glycerol phosphate (GP) buffer (chitosan-GP), and that implantation of this polymer/blood composite onto marrow-stimulated chondral defects in rabbit and sheep leads to the synthesis of more chondral repair tissue with greater hyaline character compared to marrow-stimulation alone. In the current study, we examined the modulation of cell recruitment and repair tissue characteristics at early post-surgical time points (from day 1 to 56) in a rabbit model to elucidate potential mechanisms behind this improved repair outcome. DESIGN:Thirty-three skeletally mature New Zealand White rabbits underwent bilateral arthrotomies, with each trochlea receiving a cartilage defect (3.5 mm x 4.5mm) bearing four microdrill holes (0.9 mm diameter, approximately 4 mm deep) into the subchondral bone. One defect per rabbit was treated with a chitosan-GP/blood implant, while the other defect was left as a microdrilled control. Repair tissues were stained by histochemistry, for collagen types I, II, and X by immunohistochemistry and analyzed using quantitative stereological tools. RESULTS:Histological analyses demonstrated that control defects followed a typical healing sequence observed previously in marrow-stimulation animal models while chitosan-GP/blood implants led to three significant modifications in the healing sequence at early stages: (1) increased inflammatory and marrow-derived stromal cell recruitment to the microdrill holes, (2) increased vascularization of the provisional repair tissue in the microdrill holes, and (3) increased intramembranous bone formation and subchondral bone remodeling (BR). CONCLUSIONS:These results suggest that the greater levels of provisional tissue vascularization and BR activity are main factors supporting improved cartilage repair when chitosan-GP/blood implants are applied to marrow-stimulated cartilage lesions.
    背景与目标:
  • 【去甲后植入物插入类过敏反应: 一例报告。】 复制标题 收藏 收藏
    DOI:10.1016/s0010-7824(97)00038-3 复制DOI
    作者列表:Gbolade BA
    BACKGROUND & AIMS: Presented is the first reported case of an anaphylactoid reaction following Norplant contraceptive implant insertion. The 19-year-old UK woman denied any history of allergic reaction to local anesthesia. After subcutaneous infiltration with 50 mg of 1% lidocaine (without adrenalin), 6 Norplant capsules were inserted through use of the standard insertion technique. Shortly after completion of the procedure, the patient collapsed and had 2 short convulsions. Her blood pressure dropped to 80/40 mm Hg and her radial pulse was 60 beats/minute and thready. Recovery was rapid following administration of intramuscular adrenalin and intravenous hydrocortisone. The woman later recalled a similar episode during a visit to her dentist. An estimated 3 in every 100,000 patients receiving lignocaine hydrochloride have an episode of anaphylaxis in the hospital. In type I hypersensitivity reactions, there is often a history of previous exposure to the allergen, as occurred in this patient. Those undertaking Norplant insertion and removal should be aware of the potential for serious allergic reactions and have access to resuscitative equipment.

    背景与目标: 提出了第一例报道的Norplant避孕植入物插入后发生类过敏反应的病例。这位19岁的英国妇女否认对局部麻醉有任何过敏反应史。在皮下浸润50 mg 1% 利多卡因 (不含肾上腺素) 后,通过使用标准插入技术插入6个Norplant胶囊。手术完成后不久,患者晕倒并出现2次短暂抽搐。她的血压下降到80/40毫米汞柱,她的桡动脉脉搏是60次/分钟和微弱的。肌肉注射肾上腺素和静脉注射氢化可的松后恢复迅速。这位女士后来在去看牙医时回忆起类似的情节。每100,000名接受盐酸利诺卡因的患者中估计有3名在医院发生过敏反应。在I型超敏反应中,通常有先前暴露于过敏原的病史,如在该患者中发生的。那些进行Norplant插入和移除的人应该意识到严重过敏反应的可能性,并可以使用复苏设备。
  • 【人工耳蜗韵律感知的 [实验]。】 复制标题 收藏 收藏
    影响因子 :
    发表时间:2007-04-01
    来源期刊:HNO
    DOI:10.1007/s00106-006-1452-1 复制DOI
    作者列表:Meister H,Tepeli D,Wagner P,Hess W,Walger M,von Wedel H,Lang-Roth R
    BACKGROUND & AIMS: BACKGROUND AND OBJECTIVE:Prosody has a myriad of linguistic functions and involves specific aspects of speech, such as stress, intonation and pauses. The underlying acoustic quantities (amplitude envelope, pitch frequency, and temporal structure) can be processed and transmitted by cochlear implants (CI) only to a limited extent. At present, no adequate tests are available in the German-speaking world for evaluation of the perception of prosodic elements. Different experiments have been conducted to address several prosodic cues, and the results are to be used as a basis for appropriate tests. METHODS:Various prosodic materials were used for the experiments. Discrimination was measured for minimal pairs differing in frequency and/or duration, accents in words and phrases, questions versus statements and phrasing. Measurements were performed in ten normal-hearing subjects and five with cochlear implants. RESULTS AND CONCLUSIONS:In all test modules, the subjects with normal hearing proved to have high discrimination rates of 96-100%. The test of word stresses was problematic because the results were influenced by different confounders. The other measurements did prove to be basically suitable for use in the subjects with implants. Early results revealed that the subjects with CI had few problems with prosodic cues based on the temporal structure, the outcome being similar to that of the subjects with normal hearing in these tests. In contrast, the performance of subjects with CI in perceiving prosodic cues based on amplitude variations and, especially, on alterations in pitch frequency was worse, even though some of them achieved very good results in these tests too. These preliminary tests can form the basis for development of a German-language prosody test battery with a limited number of subtests addressing different prosodic cues.
    背景与目标:
  • 【NIDCR R25赠款支持对研究型非密集型牙科学校的课程和文化的影响。】 复制标题 收藏 收藏
    DOI:10.1177/154405910708600701 复制DOI
    作者列表:Iacopino AM,Pryor ME,Taft TB,Lynch DP
    BACKGROUND & AIMS: :Our objective was to evaluate changes in curriculum and culture within a research non-intensive dental school after implementation of programs supported by the NIH-NIDCR R25 Oral Health Research Curriculum Grant. We designed new curricular elements to foster an appreciation of research/discovery, an interest in academic/research careers, and application of biomedical/clinical advances to patient care. Funding was utilized to develop, implement, and assess a dedicated curricular track of continuous student research/scholarly activity throughout the four years of dental education. This track represented mandatory hours of didactic time exposing students to topics not traditionally included in dental curricula. Additionally, students were provided with customized flexible schedules to participate in elective "hands-on" mentored research/scholarly experiences at local, national, and international sites, including linkages to certificate, MS, and PhD programs. Funding was also used to support a wide array of faculty development activities that provided skill sets required to deliver integrated biomedical/clinical content, research-oriented evidence-based approaches to dental education, and translational case-based teaching methods emphasizing the application of new science/technologies to patient care. We measured changes in student, faculty, and institutional profiles/attitudes using traditional benchmarks, surveys, and focus groups. Comparisons were made between baseline data prior to R25 program initiation and data collected after years 3-4 of program implementation. Significant increases were demonstrated in: (1) student participation in research/scholarship, attendance at national meetings, research awards, publication of manuscripts, pursuit of advanced training/degrees, and expressions of interest in academic/research careers; (2) faculty participation in development activities, publication of manuscripts, and mentoring of students; and (3) increased institutional credibility within the university, supportive infrastructure for research/scholarship, and cultural expectations for academic excellence. Thus, we believe that the R25 programming changed the culture of our dental school, creating a supportive environment for research/scholarship, increasing academic productivity, and altering the attitudes of faculty/students.
    背景与目标: : 我们的目标是在实施nih-nidcr R25口腔健康研究课程补助金支持的计划后,评估非密集型牙科学校课程和文化的变化。我们设计了新的课程元素,以促进对研究/发现的欣赏,对学术/研究职业的兴趣以及将生物医学/临床进展应用于患者护理。在整个牙科教育的四年中,资金用于开发,实施和评估持续的学生研究/学术活动的专用课程。此曲目代表了强制性的教学时间,使学生接触传统上不包括在牙科课程中的主题。此外,还为学生提供了定制的灵活时间表,以参加在本地,国家和国际站点上进行的选修 “动手” 指导的研究/学术经验,包括与证书,MS和博士学位课程的联系。资金还用于支持广泛的教师发展活动,这些活动提供了提供综合生物医学/临床内容所需的技能,以研究为基础的基于证据的牙科教育方法以及强调应用新的案例的基于案例的教学方法。科学/技术用于患者护理。我们使用传统的基准,调查和焦点小组来衡量学生,教师和机构概况/态度的变化。比较了R25计划启动前的基线数据和计划实施3-4年后收集的数据。显着增加的表现是 :( 1) 学生参与研究/奖学金,参加国家会议,研究奖,手稿的出版,追求高级培训/学位以及对学术/研究职业的兴趣表达; (2) 教师参与发展活动,手稿的出版,和指导学生; (3) 提高大学内部的机构信誉,支持研究/奖学金的基础设施以及对学术卓越的文化期望。因此,我们认为,R25编程改变了我们牙科学校的文化,为研究/奖学金创造了支持环境,提高了学术生产力,并改变了教师/学生的态度。
  • 【基于毛细管的微等离子体系统,用于消毒牙科生物膜。】 复制标题 收藏 收藏
    DOI:10.3109/09553002.2013.756594 复制DOI
    作者列表:Huang WK,Weng CC,Liao JD,Wang YC,Chuang SF
    BACKGROUND & AIMS: PURPOSE:A low-temperature low-energy capillary-tube-based argon micro-plasma system was applied to disinfect Streptococcus mutans-containing biofilm. MATERIALS AND METHODS:The micro-plasma system uses a hollow inner electrode that is ignited by a radio-frequency power supply with a matching network. The energy content was analyzed using optical emission spectroscopy. The micro-plasma-induced effect on a biofilm cultured for 24 or 48 h with a working distance of ≈3 mm at low temperature was evaluated. The morphologies of the treated live/dead bacteria and the produced polysaccharides after micro-plasma treatment were examined. RESULTS:Scanning electron microscopy images and staining results show that most of the S. mutans on the treated biofilm were acutely damaged within a micro-plasma treatment time of 300 s. CONCLUSIONS:The number of living bacteria underneath the treated biofilm greatly decreased with treatment time. The proposed micro-plasma system can thus disinfect S. mutans on/in biofilms.
    背景与目标:
  • 【牙科印模晶片上捕获的DNA的鉴定和长期稳定性。】 复制标题 收藏 收藏
    DOI: 复制DOI
    作者列表:Kim M,Siegler K,Tamariz J,Caragine T,Fernandez J,Daronch M,Moursi A
    BACKGROUND & AIMS: PURPOSE:The purpose of this study was to determine the quantity and quality of DNA extracted from a dental bite impression wafer immediately after impression and after 12 months of home storage. The authors' hypothesis was that the wafer would retain sufficient DNA with appropriate genetic markers to make an identification match. METHODS:Two impression wafers (Toothprints(®) brand) were administered to 100 3- to 26-year-olds. A cotton swab was used as a control. DNA from wafers stored for 12 months at home were compared to DNA collected at time 0 and compared to swabs at specific sites to determine quality and accuracy. The amount of DNA captured and recovered was analyzed using MagAttract technology and a quantitative real-time polymerase chain reaction. Capillary gel electrophoresis was performed to determine the quality of the DNA profiles obtained from the wafers vs those generated from the swabs of each subject. RESULTS:Average DNA concentration was: 480 pg/μL (wafer at time 0); 392 pg/μL (wafer after 12 months kept by subjects); and 1,041 pg/μL (buccal swab). Sufficient DNA for human identification was recovered from all sets of wafers, producing clear DNA profiles and accurate matches to buccal swabs. No inhibitors were found that could interfere with DNA profiling. CONCLUSIONS:Toothprints® impression wafers can be useful for DNA collection and child identification. After 12 months, the wafer was still usable for DNA capture and identification match.
    背景与目标:
  • 【远程医疗和心脏植入物: 有什么好处?】 复制标题 收藏 收藏
    DOI:10.1093/eurheartj/ehs388 复制DOI
    作者列表:Varma N,Ricci RP
    BACKGROUND & AIMS: :Cardiac implantable electronic devices are increasing in prevalence. The post-implant follow-up is important for monitoring both device function and patient condition. However, practice is inconsistent. For example, ICD follow-up schedules vary from 3 monthly to yearly according to facility and physician preference and availability of resources. Recommended follow-up schedules impose significant burden. Importantly, no surveillance occurs between follow-up visits. In contrast, implantable devices with automatic remote monitoring capability provide a means for performing constant surveillance, with the ability to identify salient problems rapidly. Remote home monitoring reduces the volume of device clinic visits and provides early detection of patient and/or system problems.
    背景与目标: : 心脏植入式电子设备的患病率正在上升。植入后的随访对于监测设备功能和患者状况都很重要。然而,实践是不一致的。例如,根据设施和医生的偏好以及资源的可用性,ICD随访时间表从3个月到每年不等。建议的后续时间表带来了巨大的负担。重要的是,在后续访问之间没有监视。相反,具有自动远程监视功能的可植入设备提供了一种执行持续监视的方法,具有快速识别突出问题的能力。远程家庭监控减少了设备诊所就诊的数量,并提供了对患者和/或系统问题的早期检测。
  • 【模拟双侧人工耳蜗插入深度的耳间不匹配对语音感知的影响。】 复制标题 收藏 收藏
    DOI:10.1121/1.4812272 复制DOI
    作者列表:van Besouw RM,Forrester L,Crowe ND,Rowan D
    BACKGROUND & AIMS: :A bilateral advantage for diotically presented stimuli has been observed for cochlear implant (CI) users and is suggested to be dependent on symmetrical implant performance. Studies using CI simulations have not shown a true "bilateral" advantage, but a "better ear" effect and have demonstrated that performance decreases with increasing basalward shift in insertion depth. This study aimed to determine whether there is a bilateral advantage for CI simulations with interaurally matched insertions and the extent to which performance is affected by interaural insertion depth mismatch. Speech perception in noise and self-reported ease of listening were measured using matched bilateral, mismatched bilateral and unilateral CI simulations over four insertion depths for seventeen normal hearing listeners. Speech scores and ease of listening reduced with increasing basalward shift in (interaurally matched) insertion depth. A bilateral advantage for speech perception was only observed when the insertion depths were interaurally matched and deep. No advantage was observed for small to moderate interaural insertion-depth mismatches, consistent with a better ear effect. Finally, both measures were poorer than expected for a better ear effect for large mismatches, suggesting that misalignment of the electrode arrays may prevent a bilateral advantage and detrimentally affect perception of diotically presented speech.
    背景与目标: : 对于人工耳蜗 (CI) 使用者,已经观察到双向呈现刺激的双边优势,并且建议这取决于对称的植入性能。使用CI模拟的研究并未显示出真正的 “双边” 优势,而是 “更好的耳朵” 效果,并且表明性能会随着插入深度的玄武向偏移而降低。这项研究旨在确定使用耳间匹配插入的CI模拟是否具有双边优势,以及耳间插入深度不匹配对性能的影响程度。使用匹配的双侧,不匹配的双侧和单侧CI模拟,对17名正常听力听众在四个插入深度上测量了噪声中的语音感知和自我报告的听力难易程度。随着 (耳间匹配) 插入深度的basalward偏移的增加,语音分数和听力的难易程度会降低。仅当插入深度在耳间匹配且较深时,才观察到语音感知的双边优势。对于小到中等的耳间插入深度不匹配,没有观察到优势,这与更好的耳朵效果一致。最后,这两种措施都比预期的要差,因为对于较大的不匹配,耳朵效果更好,这表明电极阵列的不对准可能会阻止双边优势,并不利地影响对语音呈现的感知。
  • 【部分缺牙患者的即刻非咬合与牙种植体的早期负荷: 一项多中心随机临床试验。种植体周围骨和软组织水平。】 复制标题 收藏 收藏
    DOI:10.1111/j.1600-0501.2008.01530.x 复制DOI
    作者列表:Galli F,Capelli M,Zuffetti F,Testori T,Esposito M
    BACKGROUND & AIMS: OBJECTIVES:To compare peri-implant bone and soft-tissue levels of immediately non-occlusally loaded vs. non-submerged early loaded implants in partially edentulous patients up to 14 months after placement. MATERIAL AND METHODS:Fifty-two patients were randomized in five Italian private practices: 25 in the immediately loaded group and 27 in the early loaded group. To be immediately loaded, single implants had to be inserted with a torque of > or = 30 N cm, and splinted implants with a torque of > or = 20 N cm. Immediately loaded implants were provided with non-occluding temporary restorations within 48 h. After 2 months, the provisional restorations were placed in full occlusion. Implants were early loaded after 2 months. Final restorations were provided 8 months after placement. Blinded assessors evaluated peri-implant bone and soft-tissue levels. RESULTS:Fifty-two implants were immediately loaded and 52 were early loaded. No drop-out occurred. One single immediately loaded implant failed 2 months after placement. Both groups gradually lost peri-implant bone in a highly statistically significant manner at 2, 8, and 14 months. After 14 months, patients of both groups lost an average of 1.1 mm of peri-implant bone. There were no statistically significant differences between the two loading strategies for peri-implant bone and soft-tissue level changes (P > 0.05). After 14 months, the position of the soft tissues did not change significantly from baseline (delivery of the final restorations 8 months after placement). CONCLUSIONS:There were no statistically or clinically significant differences between immediate and early loading of dental implants with regard to peri-implant bone and soft-tissue levels as evaluated in the present study.
    背景与目标:
  • 【克罗地亚成年牙科患者根系扩张的患病率。】 复制标题 收藏 收藏
    DOI:10.1016/j.tripleo.2005.08.021 复制DOI
    作者列表:Malcić A,Jukić S,Brzović V,Miletić I,Pelivan I,Anić I
    BACKGROUND & AIMS: OBJECTIVE:To determine the prevalence and distribution of dilaceration in all tooth groups by using radiographs. STUDY DESIGN:The sample included 953 periapical intraoral radiographs and 488 panoramic radiographs from different caucasian patients. The ages of the patients ranged from 18-65 years. Dilaceration of the root was detected by measuring the degree of deviation from the long axis (deviation ł 90 degrees), and evaluating the "bull's eye" appearance. The prevalence of root dilaceration for each tooth-type was expressed in percentages. RESULTS:The teeth showing the highest prevalence of root dilaceration were mandibular third molars (24.1%), maxillary first molars (15.3%), second molars (11.4%) and third molars (8.1%). In the mandible, dilacerations were less common than in the maxilla. CONCLUSIONS:In the adult population examined in Croatia, dilaceration was most frequently found to affect posterior teeth.
    背景与目标:
  • 【雅典2004奥运会和残奥会的牙科数据。】 复制标题 收藏 收藏
    DOI:10.1055/s-2008-1038489 复制DOI
    作者列表:Vougiouklakis G,Tzoutzas J,Farmakis ET,Farmakis EE,Antoniadou M,Mitsea A
    BACKGROUND & AIMS: :The Athens University, School of Dentistry, accepted the challenge to organize the Dental Health Services in the Athens 2004 Olympic and Paralympic Games in order to provide the best quality of oral health services to the athletes, coaches, escort members and Olympic Village personnel. Data from the whole activity protocol of the Athens 2004 Games Dental Health Services - the reception, admission and treatment protocols, the facilities and the infrastructure, the number of cases treated per specialty and the experience gained - were recorded. During the Olympic Games, there were more than 1400 dental cases in more than 650 patients, elite athletes, escort members, coaches and staff of the Olympic Village. Among them 313 fillings, 100 root canal therapies, 57 mouthguards and 9 dental trauma cases were treated. During the Paralympic Games, there were more than 240 dental cases in more than 220 patients. Among them 73 fillings, 12 root canal therapies, 21 extractions and 3 dental trauma cases were treated. In such events, highly trained dentists are needed and if possible, specialized in operative dentistry or endodontics. The role of team dentist seems to be of great importance.
    背景与目标: : 雅典大学牙科学院接受了在雅典2004奥运会和残奥会上组织牙科保健服务的挑战,以便为运动员,教练,护送成员和奥运村人员提供最优质的口腔保健服务。记录了来自雅典2004运动会牙科保健服务的整个活动协议的数据-接收,准入和治疗协议,设施和基础设施,每个专业治疗的病例数以及获得的经验。奥运会期间,奥运村650多名患者、优秀运动员、护卫队员、教练员和工作人员共发生了1400多例牙病病例。其中补牙313例,根管治疗100例,护齿57例,牙外伤9例。残奥会期间,220多名患者中有240多个牙科病例。其中73例补牙,12例根管治疗,21例拔牙和3例牙外伤。在这种情况下,需要训练有素的牙医,如果可能的话,需要专门从事牙科手术或牙髓学。团队牙医的角色似乎非常重要。
  • 【巴西米纳斯吉拉斯州Juiz de Fora公立托儿所儿童初级牙列中的龋齿。】 复制标题 收藏 收藏
    DOI:10.1590/s0102-311x2000000300020 复制DOI
    作者列表:Leite IC,Ribeiro RA
    BACKGROUND & AIMS: :The aim of this study was to assess the prevalence of dental caries in the primary dentition and associated variables in low socioeconomic preschool children enrolled in public nursery schools in Juiz de Fora, Minas Gerais, Brazil. Four public institutions were selected by geographic criteria (two in the central region and two in the peripheral region). The study population comprised 338 children (181 boys; 157 girls) aged 2-6 years old. Dental caries was recorded using the decayed, missing, and filled teeth (dmf-t) index. Among the examined children, 50.6% were caries-free. The mean dmf-t index was 2.03. It was higher in the peripheral nursery schools (p<0.01). A trend towards a difference between sexes (p = 0.06) was observed. Logistic regression analysis selected a previous child's visit to dentist (p<0.001), geographic location of the public nursery school (p<0.01), and age (p<0.01) as predictive variables for the dmf-t index. The study showed the need for an oral health program for this population, including both curative and preventive measures in order to achieve the WHO/FDI goals for the year 2000, namely 50% of children free of caries at age 5-6 years.
    背景与目标: : 这项研究的目的是评估在巴西米纳斯吉拉斯州Juiz de Fora的公立托儿所就读的低社会经济学龄前儿童的主要牙列中龋齿的患病率和相关变量。根据地理标准选择了四个公共机构 (两个在中部地区,两个在外围地区)。研究人群包括2-6岁的338名儿童 (181名男孩; 157名女孩)。使用腐烂,缺失和填充的牙齿 (dmf-t) 指数记录龋齿。在接受检查的儿童中,有50.6% 人没有龋齿。平均dmf-t指数为2.03。在外围托儿所中较高 (p<0.01)。观察到性别差异的趋势 (p = 0.06)。Logistic回归分析选择了以前的儿童去看牙医 (p<0.001),公立托儿所的地理位置 (p<0.01) 和年龄 (p<0.01) 作为dmf-t指数的预测变量。该研究表明,需要为这一人群制定口腔保健方案,包括治疗和预防措施,以实现世卫组织/外国直接投资2000年的目标,即50% 5-6岁无龋齿儿童。
  • 【将牙种植体移入翼状窝: 临床报告。】 复制标题 收藏 收藏
    DOI:10.1111/jopr.13126 复制DOI
    作者列表:Dryer RR,Conrad HJ
    BACKGROUND & AIMS: :The placement of dental implants in the pterygomaxillary region can be advantageous in maxillary complete arch fixed implant-supported prosthetic rehabilitations to avoid bone grafting and sinus elevation surgeries. Pterygomaxillary implants improve implant biomechanics by eliminating distal cantilevers and increasing the anteroposterior spread with reported mean implant survival rates comparable to traditional implant sites. Although only minor surgical complications have been reported in the literature with the placement of dental implants in the pterygomaxillary region this clinical report describes a major surgical complication involving the displacement of a dental implant into the pterygoid fossa.
    背景与目标: : 在上颌完全弓固定植入物支持的假体康复中,在翼状翼状区域放置牙科植入物可能是有利的,以避免植骨和鼻窦抬高手术。翼状翼状植入物通过消除远端悬臂并增加前后扩散来改善植入物的生物力学,据报道,平均植入物存活率可与传统植入物部位相媲美。尽管在文献中仅报道了在翼状翼状区域放置牙科植入物的较小的手术并发症,但该临床报告描述了一种主要的手术并发症,涉及将牙科植入物移位到翼状窝中。
  • 【通过基质细胞衍生因子1α 和纤连蛋白的侧特异性涂层控制自体再细胞化并抑制脱细胞血管植入物的变性。】 复制标题 收藏 收藏
    DOI:10.1088/1748-605X/ab54e3 复制DOI
    作者列表:Sugimura Y,Chekhoeva A,Oyama K,Nakanishi S,Toshmatova M,Miyahara S,Barth M,Assmann AK,Lichtenberg A,Assmann A,Akhyari P
    BACKGROUND & AIMS: :Optimized biocompatibility is crucial for the durability of cardiovascular implants. Previously, a combined coating with fibronectin (FN) and stromal cell-derived factor 1α (SDF1α) has been shown to accelerate the in vivo cellularization of synthetic vascular grafts and to reduce the calcification of biological pulmonary root grafts. In this study, we evaluate the effect of side-specific luminal SDF1α coating and adventitial FN coating on the in vivo cellularization and degeneration of decellularized rat aortic implants. Aortic arch vascular donor grafts were detergent-decellularized. The luminal graft surface was coated with SDF1α, while the adventitial surface was coated with FN. SDF1α-coated and uncoated grafts were infrarenally implanted (n = 20) in rats and followed up for up to eight weeks. Cellular intima population was accelerated by luminal SDF1α coating at two weeks (92.4 ± 2.95% versus 61.1 ± 6.51% in controls, p < 0.001). SDF1α coating inhibited neo-intimal hyperplasia, resulting in a significantly decreased intima-to-media ratio after eight weeks (0.62 ± 0.15 versus 1.35 ± 0.26 in controls, p < 0.05). Furthermore, at eight weeks, media calcification was significantly decreased in the SDF1α group as compared to the control group (area of calcification in proximal arch region 1092 ± 517 μm2 versus 11 814 ± 1883 μm2, p < 0.01). Luminal coating with SDF1α promotes early autologous intima recellularization in vivo and attenuates neo-intima hyperplasia as well as calcification of decellularized vascular grafts.
    背景与目标: : 优化的生物相容性对于心血管植入物的耐久性至关重要。以前,已显示具有纤连蛋白 (FN) 和基质细胞衍生因子1α (SDF1α) 的组合涂层可加速合成血管移植物的体内细胞化并减少生物肺根移植物的钙化。在这项研究中,我们评估了侧特异性腔SDF1α 涂层和外膜FN涂层对脱细胞大鼠主动脉植入物体内细胞化和变性的影响。主动脉弓血管供体移植物被去污剂脱细胞。腔移植物表面涂有SDF1α,而外膜表面涂有FN。将sdf1α 涂层和未涂层的移植物在大鼠体内植入 (n = 20),并进行长达八周的随访。在两周时,腔膜SDF1α 涂层加速了细胞内膜群 (对照组为92.4 ± 2.95%,对照组为61.1 ± 6.51%,p <0.001)。SDF1α 涂层抑制新内膜增生,导致8周后内膜与中膜比率显着降低 (对照组为0.62 ± 0.15,对照组为1.35 ± 0.26,p <0.05)。此外,与对照组相比,在8周时,SDF1α 组的介质钙化显着降低 (近端弓区域的钙化面积1092 ± 517 μm2与11 814 ± 1883 μm2相比,p <0.01)。带有SDF1α 的腔涂层可促进体内早期自体内膜再细胞化,并减轻新内膜增生以及脱细胞血管移植物的钙化。
  • 【在伦敦的三个行政区获得初级牙科保健。】 复制标题 收藏 收藏
    DOI: 复制DOI
    作者列表:Adams T,Freeman R,Gelbier S,Gibson B
    BACKGROUND & AIMS: OBJECTIVE:To investigate and identify factors that may influence individuals' ability to access primary health care services.

    DESIGN:Cross-sectional study

    SETTING:Lambeth, Southwark and Lewisham.

    SUBJECTS:A 0.1 per cent random sample of people aged 18 years and over in the population of 626,621 people in the three boroughs.

    MAIN OUTCOME MEASURES:Demographic as well as psychosocial profile of the sample, perceptions of their dental health needs, accessed dental care.

    RESULTS:The results indicated that people believed that their oral health was good. The majority of the sample had attended for dental care within the previous year and were registered with a general dental practitioner. Accessing dental care was related to age, social class, borough of residence, dentate status and dental phobia status. In addition subjects experiencing problems with their teeth gained access to care more readily than others. This was related to social class. Accessing dental care was predicted by dental care being provided by a general dental practitioner, experiencing problems with teeth and not being dentally phobic.

    CONCLUSIONS:The findings suggest that psychosocial factors together with dental health status can act as determinants when accessing primary dental services. It is considered that family health services authorities should be aware of these influences when developing and monitoring dental health services, in order to make them responsive and sensitive to the needs of the people whom they serve.

    背景与目标: 目标 : 调查和确定可能影响个人获得初级卫生保健服务能力的因素。
    设计 : 横断面研究
    设置 : lambeth,Southwark和Lewisham。
    主题 : 在三个行政区的626,621人中,对18岁及以上的人口进行了0.1的随机抽样。
    主要结果指标 : 人口统计以及样本的社会心理状况,对牙齿健康需求的看法,访问了牙科保健。
    结果 : 结果表明人们认为自己的口腔健康良好。大多数样本在上一年内参加了牙科护理,并在普通牙科医生处注册。获得牙科保健与年龄,社会阶层,居住区,牙齿状况和牙科恐惧症状况有关。此外,牙齿出现问题的受试者比其他人更容易获得护理。这与社会阶层有关。通过由普通牙科医生提供的牙科护理来预测获得牙科护理,他们会遇到牙齿问题并且不会感到牙齿恐惧症。
    结论 : 研究结果表明,心理社会因素以及牙齿健康状况可以作为获得初级牙科服务的决定因素。人们认为,家庭保健服务当局在开发和监测牙科保健服务时应意识到这些影响,以使其对所服务的人的需求敏感和敏感。

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