Current clinical practice for patients presenting to the emergency department with a resolved episode of chest pain and no electrographic or biomarker abnormalities is to conduct routine noninvasive testing, in accordance with American College of Cardiology and American Heart Association guidelines. The rationale is to further reduce the risk of missing a myocardial infarction, a major source of suits filed against emergency department physicians. Patients with negative stress test results may be reassured, with low event rates in the subsequent 30 days. Patients with positive stress test results have higher 30-day event rates, and a small fraction undergo revascularization procedures. Despite this endorsement, open questions remain. Does our current practice lead to the stenting of asymptomatic patients in the inevitable cases where the inciting pain was noncardiac? And, most importantly, does our practice improve outcomes? Randomized trials evaluating routine stress testing in other contexts have yielded negative results, despite diagnosing significant coronary artery disease. Population data suggest that our current practice may be increasing the diagnosis of coronary artery disease and the rate of intervention while failing to decrease rates of myocardial infarction. We propose that randomized trials be conducted to evaluate whether any testing is better than no further intervention. Data from such an evidence-based approach has the potential to reverse our current practice.

译文

根据美国心脏病学会和美国心脏协会的指南,针对急诊就诊的胸痛发作且无电子照相或生物标志物异常的患者,目前的临床实践是进行常规的无创检测。理由是进一步降低错过心肌梗死的风险,心肌梗死是针对急诊科医生提起诉讼的主要来源。负压力测试结果的患者可能会放心,随后30天的事件发生率较低。具有积极压力测试结果的患者的30天事件发生率较高,并且一小部分患者接受了血运重建手术。尽管有这种认可,但悬而未决的问题仍然存在。在不可避免的非心脏性疼痛情况下,我们目前的做法是否导致无症状患者支架置入?而且,最重要的是,我们的实践是否改善了结果?尽管诊断出明显的冠状动脉疾病,但在其他情况下评估常规压力测试的随机试验却产生了阴性结果。人口数据表明,我们目前的做法可能会增加对冠状动脉疾病的诊断和干预率,而未能降低心肌梗塞的发生率。我们建议进行随机试验以评估是否有任何测试比没有进一步干预更好。来自这种基于证据的方法的数据有可能扭转我们目前的做法。

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